Abstract
Most breast cancer patients who remain disease free after local and regional treatment eventually relapse and die of or with overt metastases. This is true regardless of whether they received an appropriate local therapy. The current hypothesis ascribes the failure to obtain freedom from disease to occult micrometastatic disease already present at the time of diagnosis and first surgery [1]. This hypothesis has acquired indirect support from the results of clinical trials which showed no additional advantage in terms of disease-free or overall survival for a more radical local therapy [2,3].
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© 1992 Springer-Verlag Berlin Heidelberg
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Goldhirsch, A., Castiglione, M., Gelber, R.D. (1992). Adjuvant Chemoendocrine Therapies In Pre- and Postmenopausal Breast Cancer (“Can you teach an old dog new tricks?”). In: Goldhirsch, A. (eds) Endocrine Therapy of Breast Cancer V. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77662-5_11
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DOI: https://doi.org/10.1007/978-3-642-77662-5_11
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