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Improved Polymers for Medical Implants-Polyurethanes

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Progress in Pacific Polymer Science 2

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Abstract

Polyurethane elastomers, prepared from: (i) polyether macrodiols that contain a reduced number of ether linkages compared with PTMO [poly(tetramethylene oxide)], (ii) the diisocyanate MDI [4,4’-diphenylmethanediisocyanate], and (iii) the chain extender BDO [1,4-butanediol] offer enhanced stability towards oxidation and hydrolysis over their PTMO-based counterparts. Polyurethane-ureas prepared from the diisocyanate TMXDI (m-tetramethylxylene diisocyanate), however, show decreased stability. In vivo subcutaneous implant experiments (sheep; 90 days and 180 days), show that the new MDI-based ether-reduced polyurethanes do not undergo stress cracking while the PTMO-based materials do. The TMXDI materials performed poorly when implanted.

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Authors and Affiliations

  1. CSIRO Division of Chemicals and Polymers, Private Bag 10, Clayton, Victoria, 3168, Australia

    Gordon F. Meijs, Pathiraja A. Gunatillake, Ezio Rizzardo, Simon J. McCarthy & Ronald C. Chatelier

  2. Centre for Biomedical Engineering, The University of New South Wales, P. O. Box 1, Kensington, NSW, 2033, Australia

    Arthur Brandwood & Klaus Schindhelm

Authors
  1. Gordon F. Meijs
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  2. Pathiraja A. Gunatillake
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  3. Ezio Rizzardo
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  4. Simon J. McCarthy
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  5. Ronald C. Chatelier
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  6. Arthur Brandwood
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  7. Klaus Schindhelm
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Editor information

Editors and Affiliations

  1. Department of Polymer Chemistry, Kyoto University, Kyoto, 606, Japan

    Y. Imanishi

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© 1992 Springer-Verlag Berlin Heidelberg

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Meijs, G.F. et al. (1992). Improved Polymers for Medical Implants-Polyurethanes. In: Imanishi, Y. (eds) Progress in Pacific Polymer Science 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77636-6_19

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  • DOI: https://doi.org/10.1007/978-3-642-77636-6_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77638-0

  • Online ISBN: 978-3-642-77636-6

  • eBook Packages: Springer Book Archive

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