Advertisement

The Localization of the Products of the c-cbl and v-cbl Oncogenes During Mitosis and Transformation

  • W. Y. Langdon
  • K. G. Heath
  • T. J. Blake
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 182)

Abstract

The study of proto-oncogenes has been responsible for the elucidation of a wide range of genes that encode proteins with functions that are critical in regulating cell growth and development. Although the number of proto-oncogenes is large there presently appears to be only three biochemical mechanisms by which these genes act (Bishop, 1991). These are the phosphorylation of proteins with serine, threonine and tyrosine as substrates, the transmission of signals by GTPases and the regulation of gene transcription. However, the functions of some oncogenes remain unknown and as such it is possible that this list of mechanisms may be expanded in the future.

Keywords

Total Cell Extract Differential Subcellular Localization pGEX Expression Vector Mouse Homo Fractionate Cell Extract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bishop MJ (1991) Molecular themes in oncogenesis. Cell 64:235–248.PubMedCrossRefGoogle Scholar
  2. Blake TJ, Shapiro M, Morse HC, Langdon WY (1991) The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. Oncogene 6:653–657.PubMedGoogle Scholar
  3. Blake TJ, Langdon WY (1992) A rearrangement of the c-cbl proto-oncogene in HUT78 T lymphoma cells results in a truncated protein. Oncogene 7 (in press).Google Scholar
  4. Henkel T, Zabel U, van Zee K, Muller JM, Fanning E, Baeverle PA (1992) Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-κB subunit. Cell 68:1121–1133.PubMedCrossRefGoogle Scholar
  5. Langdon WY, Hartley JW, klinken SP, Ruscetti Sk, Morse HC (1989) v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. Proc Natl Acad Sci. USA 86:1168–1172.PubMedCrossRefGoogle Scholar
  6. Smith DB, Johnson KS (1988) Single-step purification of Polypeptides expressed in Escherichia coli as fusions with glutathione-S-transferase. Gene 67:31–40.PubMedCrossRefGoogle Scholar
  7. Silver PA (1991) How proteins enter the nucleus. Cell 64:489–497.PubMedCrossRefGoogle Scholar
  8. Zelligs JD, Wollman SH (1979) Mitosis in rat thyroid epithelial cells in vivo. Ultrastructural changes in cytoplasmic organelles during the mitotic cycle. J Ultrastruct Res 66:53–77.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • W. Y. Langdon
    • 1
  • K. G. Heath
    • 1
  • T. J. Blake
    • 1
  1. 1.Hanson Centre for Cancer ResearchAdelaideAustralia

Personalised recommendations