The Localization of the Products of the c-cbl and v-cbl Oncogenes During Mitosis and Transformation
The study of proto-oncogenes has been responsible for the elucidation of a wide range of genes that encode proteins with functions that are critical in regulating cell growth and development. Although the number of proto-oncogenes is large there presently appears to be only three biochemical mechanisms by which these genes act (Bishop, 1991). These are the phosphorylation of proteins with serine, threonine and tyrosine as substrates, the transmission of signals by GTPases and the regulation of gene transcription. However, the functions of some oncogenes remain unknown and as such it is possible that this list of mechanisms may be expanded in the future.
KeywordsCellulose Sucrose Acetone Lymphoma EDTA
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