The Localization of the Products of the c-cbl and v-cbl Oncogenes During Mitosis and Transformation
The study of proto-oncogenes has been responsible for the elucidation of a wide range of genes that encode proteins with functions that are critical in regulating cell growth and development. Although the number of proto-oncogenes is large there presently appears to be only three biochemical mechanisms by which these genes act (Bishop, 1991). These are the phosphorylation of proteins with serine, threonine and tyrosine as substrates, the transmission of signals by GTPases and the regulation of gene transcription. However, the functions of some oncogenes remain unknown and as such it is possible that this list of mechanisms may be expanded in the future.
KeywordsTotal Cell Extract Differential Subcellular Localization pGEX Expression Vector Mouse Homo Fractionate Cell Extract
Unable to display preview. Download preview PDF.
- Blake TJ, Langdon WY (1992) A rearrangement of the c-cbl proto-oncogene in HUT78 T lymphoma cells results in a truncated protein. Oncogene 7 (in press).Google Scholar
- Zelligs JD, Wollman SH (1979) Mitosis in rat thyroid epithelial cells in vivo. Ultrastructural changes in cytoplasmic organelles during the mitotic cycle. J Ultrastruct Res 66:53–77.Google Scholar