Abstract
Given the availability of recombinant lymphokines, antibodies specific for various lymphokines and lymphocyte cell-surface molecules, and functional antigen-specific Th clones, homogeneous and functionally responsive B cell lines and clones would be valuable tools for studying T cell-B cell interactions and B lymphocyte differentiation. However, most of the available B cell lines to date have limited potential for differentiation. Generation of functional B cell lines has become an urgent task.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Rosenberg N, Baltimore D, Sher CD (1975) In vitro transformation of lymphoid cells by Abelson murine leukemia virus. Proc Natl Acad Sci. USA 37:1932.
Ramakrishnan L, Rosengerg N (1988) Novel B-cell precursors at the stage of DJH recombination. Mol Cell Biol 8:5216.
Serunian LA, Rosenberg N (1986) Abelson virus potentiates long-term growth of mature B lymphocytes. Mol Cell Biol 6:183.
Runnels J, Serunian L, Thursby M, Rosenberg N (1991) Moleney leukemia virus immortalizes B lymphocytes in vitro. J Virol 65:5549.
Litchman AH, Reynolds DS, Faller DF, Abbas AK (1986) Mature murine B lymphocytes immortalized by Kirsten sarcoma virus. Nature 324:489.
Rapp UR, Cleveland JL, Fredrickson TN, Holems L, Morse HC III, Jansen HW, Patschinsky T, Bister K (1985) Rapid induction of hemopoietic neoplasms in newborn mice by a raf(mil)/myc recombinant murine retrovirus. J Virol 55:23.
Principato M, Cleveland JL, Rapp UR, Holems L, Pierce JH, Morse HC III, Klinken SP (1990) Transformation of murine bone marrow cellls with combined v-raf-v-myc oncogenes yields clonally related mature B cells and macrophages. Mol Cell Biol 10:3562.
Rapp UR, Troppmair J, Carroll M, May S (1990) Role of raf-1 protein kinase in IL-3 and GM-CSF-mediated signal transduction. Curr Top Microbiol Immunol 166:129.
Kaye J, Porcelli S, Tite J, Jones B, Janeway CA Jr (1983) Both a monoclonal antibody and antisera specific for determinants unique to individual clones helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells. J Exp Med 158:836.
Yagi J, Baron J, Buxser S, Janeway CA Jr (1990) Bacterial proteins mediate the association of a defined subset of T cell receptor:CD4 complexes with class II MHC. J Immunol 144:892.
Berton MT, Uhr JW, Vitetta ES (1989) Synthesis of germline γ1 Immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon γ. Proc Natl Acad Sci. USA 86:2869.
Stavnezer J, Radcliffe G, Lin Y-C, Nietupski J, Berggren L, Sitia R, Severinson E (1988) Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes. Proc Natl Acad Sci. USA 85:7704.
Xu M, Stavnezer J (1990) Structure of germline Immunoglobulin heavy-chain γ1 transcripts in interleukin-4 treated mouse spleen cells. Dev Immunol 1:11.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Chen, Y.W., Vora, K.A., Lin, MS. (1992). Generation and Differentiation Potential of Retrovirus-Immortalized Mature Murine B Cells. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1992. Current Topics in Microbiology and Immunology, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77633-5_43
Download citation
DOI: https://doi.org/10.1007/978-3-642-77633-5_43
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-77635-9
Online ISBN: 978-3-642-77633-5
eBook Packages: Springer Book Archive