Abstract
In Burkitt’s lymphoma, c-myc is most frequently translocated from chromosome 8 (q34) to the immunoglobulin heavy chain region on chromosome 14 (q32) where its expression is deregulated by virtue of its juxtaposition to enhancer sequences [1]. Because of the frequent location of the chromosomal breakpoint in DNA regions which are normally involved in the physiological recombination of immunoglobulin genes, it has been hypothesized that the immunoglobulin recombinases normally responsible for the creation of a functional immunoglobulin gene may mediate these translocations [2]. It has also been proposed that switch recombinases could mediate a proportion of translocations — presumably, those, or a fraction of those in which the breakpoint is within a switch region [3].
Keywords
- Immunoglobulin Gene
- Switch Region
- Immunoglobulin Gene Rearrangement
- Breakpoint Location
- Germline Configuration
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Dalla-Favera R, Bergni M, Erickson J, Patterson D, Gallo RC, Croce CM (1982) Proc. Natl. Acad. Sci. USA 79:7824–7827.
Haluska FG, Finver S, Tsujimoto Y, Croce C (1981) Nature 324: 158–161.
Magrath I (1990) Adv Can Res 55:133–270.
Tonagawa S (1983) Nature 302:575–581.
Alt FW, Yancopoulos GD, Blackwell TK, Wood C, Thomas E, Boss M, Coffman B, Rosenberg N, Tonegawa S, Baltimore D (1984) EMBO J 3:1205–1219.
Gunven P, Klein G, Klein E, Norin T, Singh S (1980) Int J Cancer 25:711–719.
Griesser M, Tkachuk D, Reis MD, Mak WT (1989) Blood 73:1402–1415.
Felix CA, Poplack DG, Reaman GH, Steinberg S, Cole DE, Taylor BJ, Begley GC, Kirsch IR(1990) J Clin Oncol 8:431–442.
Coleclough C, Perry PR, Kargalainen K, Weigert M. (1981) Nature 290:372–378.
Altoik E, Klein G, Zech L, Uno M, Henriksson BE, Battat S, Ono Y, Ernberg I (1989) Proc Natl Acad Sci. USA 86:6333–6337.
Ales-Martinez JE, Cuende E, Martinez AC, Parkhouse RE, Pezzi L, Scott DW (1991) Immunology Today 12:201–205.
Cohen JH, Revillard JP, Magaud JP, Lenoir G, Willaume M, Manel AM, Vincent C, Bryon PA (1987) J Natl Canc Inst 78:235–242.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Bhatia, K., Gutierrez, M., Magrath, I.T. (1992). Burkitt’s Lymphoma Cells Frequently Carry Monoallelic DJ Rearrangements. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1992. Current Topics in Microbiology and Immunology, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77633-5_40
Download citation
DOI: https://doi.org/10.1007/978-3-642-77633-5_40
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-77635-9
Online ISBN: 978-3-642-77633-5
eBook Packages: Springer Book Archive