Abstract
B-chronic lymphocytic leukemia (B-CLL) is a disease manifested by the proliferation and accumulation of a clone(s) of medium-sized lymphocytes with mature-appearing chromatin and a characteristic surface immunophenotype. Monoclonality is usually evidenced by the presence of a single heavy and light chain immunoglobulin and or a rearranged Ig gene(s). The surface fluorescence intensity (FI) of membrane Ig is markedly diminished and ineffective rearrangements are common. Typically patients fifty years of age or older present with a stable, asymtomatic blood and marrow monoclonal B lymphocytosis. Blood lymphocytes may show considerable cytological or morphological variation between patients and within patients.
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References
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© 1992 Springer-Verlag Berlin Heidelberg
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Marti, G.E. et al. (1992). Evolution of Leukemic Heterogeneity of Human B-CLL Lymphocytes Between and Within Patients. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1992. Current Topics in Microbiology and Immunology, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77633-5_38
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DOI: https://doi.org/10.1007/978-3-642-77633-5_38
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