Abstract
The bcl-2 oncogene is normally transiently expressed both in lymphoid and myeloid cells as well as in various epithelia (Hockenbery et al. 1991). It may have a function in the transition of dividing (precursor) cells to mitotically inactive and relatively longliving daughter cells (Vaux et al., 1988, Nunez et al. 1991). The protein acts through protection against programmed cell death (apoptosis). Deregulation by the t(14; 18) translocation in lymphoid malignancies induces inappropriate cell survival and serves as one of the steps towards a fully malignant behaviour.
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© 1992 Springer-Verlag Berlin Heidelberg
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de Jong, D., Prins, F., van Krieken, H.J.M., Mason, D.Y., van Ommen, G.B., Kluin, P.M. (1992). Subcellular Localization of bcl-2 Protein. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1992. Current Topics in Microbiology and Immunology, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77633-5_35
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DOI: https://doi.org/10.1007/978-3-642-77633-5_35
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