Genes Expressed Selectively in Plasmacytomas: Markers of Differentiation and Transformation

  • P. L. Bergsagel
  • C. Victor-Kobrin
  • L. A. Brents
  • J. F. Mushinski
  • W. M. Kuehl
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 182)


Plasmacytomas differ from B lymphomas in a number of ways: Plasmacytomas have a distinct plasmacytoid morphology, lack expression of certain B cell markers (e.g., Ia), express much greater levels of immunoglobulin and interact with epithelial cells in the secretion of IgA. However, there are few if any, molecular markers unique to plasmacytomas. To characterize the molecular basis for the differences between plasmacytomas and B lymphomas, we have constructed a murine plasmacytoma (MPC11) minus highly differentiated B lymphoma (A20.2J) subtractive cDNA library [1, 2]. This strategy should enrich for two classes of genes: genes differentially expressed in both normal and malignant plasma cells, and genes differentially expressed only in malignant plasma cells. As summarized below, we have identified plasmacytoma specific genes of both types.


Subtractive cDNA Library Malignant Plasma Cell Placental Alkaline Phosphatase Hydrophobic Transmembrane Domain Normal Plasma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • P. L. Bergsagel
    • 1
  • C. Victor-Kobrin
    • 1
  • L. A. Brents
    • 1
  • J. F. Mushinski
    • 1
    • 2
  • W. M. Kuehl
    • 1
  1. 1.Navy Medical Oncology BranchNational Cancer InstituteBethesdaUSA
  2. 2.Laboratory of GeneticsNational Cancer InstituteBethesdaUSA

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