Circulating B Lymphocytes in Multiple Myeloma Patients Contain an Autocrine IL-6 Driven Pre-Myeloma Cell Population
Among the unanswered questions in the development of multiple myeloma are the level of hematopoietic development of the myeloma stem cell,1 the tissue site of initiation (bone marrow? lymph node?) 2,3 and the role of IL-6 in myeloma development. 4-6 The involvement of B lymphocytes in the bone marrow and blood in myeloma has been suggested initially by identifying B cells displaying concordant isotype and idiotype, 7-9 followed by the demonstration of a circulating clonal B cell population with a concordant JH rearrangement.10 Abnormal B cells from the marrow of myeloma patients could be differentiated into the myeloma cells upon stimulation,11 the first functional demonstration of B cell involvement. Similarly, blood mononuclear cells from myeloma patients cultured with IL-3 and IL-612 or co-cultured with autologous bone marrow stromal cells13 differentiated into plasma cells containing the concordant monotypic immunoglobulin.
KeywordsMigration Lymphoma Tyrosine Leukemia Germinal
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