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Regulation of Switch Recombination to the Murine γ 1 Gene

  • W. Dunnick
  • L. Elenich
  • J. Berry
  • D. Albrecht
  • J. Stavnezer
  • J. Latham Claflin
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 182)

Abstract

The Immunoglobulin heavy chain switch, in which a variable region gene is rearranged from association with the Cμ gene to association with a C7, Ce, or Cα gene, is mediated by a recombination event between switch (S) regions [reviewed in 1]. Switch regions are 2 to 10 kb segments of simple sequences repeated in tandem and are found upstream of each of the heavy chain C genes, except Cδ [1]. Switch recombination is regulated in a gene-specific way; individual B cells direct recombination to one, or sometimes two, CH genes out of the six possible genes. For example, B cells treated with a mitogen, like lipopolysaccharide (LPS), and moderate amounts of interleukin 4 (IL4) switch almost exclusively to the γ1 gene [2, 3].

Keywords

Heavy Chain Gene Switch Region Trans Gene Variable Region Gene Endogenous Locus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • W. Dunnick
    • 1
  • L. Elenich
    • 1
  • J. Berry
    • 1
  • D. Albrecht
    • 2
  • J. Stavnezer
    • 2
  • J. Latham Claflin
    • 1
  1. 1.Department of Microbiology and ImmunologyUniversity of Michigan, Medical SchoolAnn ArborUSA
  2. 2.Department of Molecular Genetics and MicrobiologyUniversity of Massachusetts Medical SchoolWorcesterUSA

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