Regulation of Switch Recombination to the Murine γ 1 Gene

  • W. Dunnick
  • L. Elenich
  • J. Berry
  • D. Albrecht
  • J. Stavnezer
  • J. Latham Claflin
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 182)


The Immunoglobulin heavy chain switch, in which a variable region gene is rearranged from association with the Cμ gene to association with a C7, Ce, or Cα gene, is mediated by a recombination event between switch (S) regions [reviewed in 1]. Switch regions are 2 to 10 kb segments of simple sequences repeated in tandem and are found upstream of each of the heavy chain C genes, except Cδ [1]. Switch recombination is regulated in a gene-specific way; individual B cells direct recombination to one, or sometimes two, CH genes out of the six possible genes. For example, B cells treated with a mitogen, like lipopolysaccharide (LPS), and moderate amounts of interleukin 4 (IL4) switch almost exclusively to the γ1 gene [2, 3].


Heavy Chain Gene Switch Region Trans Gene Variable Region Gene Endogenous Locus 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • W. Dunnick
    • 1
  • L. Elenich
    • 1
  • J. Berry
    • 1
  • D. Albrecht
    • 2
  • J. Stavnezer
    • 2
  • J. Latham Claflin
    • 1
  1. 1.Department of Microbiology and ImmunologyUniversity of Michigan, Medical SchoolAnn ArborUSA
  2. 2.Department of Molecular Genetics and MicrobiologyUniversity of Massachusetts Medical SchoolWorcesterUSA

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