Abstract
Transgenic mice are discussed which carry a rearrangment test transgene. The methylation status of the transgene varies, depending on the background mouse strain. When the transgene is bred into the C57BL/6 strain, it is completely methylated and not rearranged in lymphoid organs. After several generations of crossing into DBA/2 or SJL the transgene becomes unmethylated and rearranges at high frequency. A strain specific modifier of DNA methylation (Ssm-1) was mapped close to the Friend virus susceptibility locus (Fv-1) on mouse chromosome 4.
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© 1992 Springer-Verlag Berlin Heidelberg
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Storb, U. et al. (1992). Rearrangement and Expression of Immunoglobulin Genes in Transgenic Mice. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1992. Current Topics in Microbiology and Immunology, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77633-5_16
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DOI: https://doi.org/10.1007/978-3-642-77633-5_16
Publisher Name: Springer, Berlin, Heidelberg
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