Advertisement

Erythema Migrans and Early Signs and Symptoms

  • K. Weber
  • U. Neubert
  • S. A. Büchner

Abstract

Erythema migrans is a homogeneous or ring-shaped erythematous and usually peripherally expanding skin lesion caused by Borrelia burgdorferi.

Keywords

Lyme Disease Borrelia Burgdorferi Lyme Borreliosis Erythema Migrans Serum Glutamate Pyruvate Transaminase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Afzelius A (1910) Verhandlungen der Dermatologischen Gesellschaft zu Stockholm, 28 Oct 1909. Arch Dermatol Syph 101:404Google Scholar
  2. Afzelius A (1921) Erythema chronicum migrans. Acta Derm Venereol (Stockh) 2:120–125Google Scholar
  3. Allen C (1948) Persistent “insect bites” (dermal eosinophilic granulomas) simulating lymphoblastomas, histiocytoses and squamous cell carcinomas. Am J Pathol 24:367–375PubMedGoogle Scholar
  4. Asbrink E, Hovmark A (1988) Early and late cutaneous manifestations in Ixodes-borne borreliosis (erythema migrans borreliosis, Lyme borreliosis). Ann NY Acad Sci 539:4–15PubMedCrossRefGoogle Scholar
  5. Asbrink E, Olsson I (1985) Clinical manifestations of erythema chronicum migrans Afzelius in 161 patients. Acta Derm Venereol (Stockh) 65:43–52Google Scholar
  6. Asbrink E, Hovmark A, Hederstedt B (1984) The spirochetal etiology of acrodermatitis chronic atrophicans Herxheimer. Acta Derm Venereol (Stockh) 64:506–512Google Scholar
  7. Asbrink E, Olsson I, Hovmark A (1986) Erythema chronicum migrans Afzelius in Sweden. A study on 231 patients. Zentralbl Bakteriol Mikrobiol Hyg (A) 263:229–236Google Scholar
  8. Berger BW (1984) Erythema chronicum migrans of Lyme disease. Arch Dermatol 120:1017- 1021PubMedCrossRefGoogle Scholar
  9. Bowen GS, Griffin M, Hayne C, Slade J, Schulze TL, Parkin W (1984) Clinical manifestations and descriptive epidemiology of Lyme disease in New Jersey, 1978 to 1982. JAMA 251:2236–2240PubMedCrossRefGoogle Scholar
  10. Bruder K (1950) Zur Kenntnis des Erythema chronicum migrans (Lipschütz). Dermatol Wochenschr 121:337–344PubMedGoogle Scholar
  11. Büchner SA, Rufli T (1987) Erythema chronicum migrans: evidence for cellular immune reaction in the skin lesion. Dermatologica 174:144–149PubMedCrossRefGoogle Scholar
  12. Burg G, Braun-Falco O (1983) Cutaneous lymphomas, pseudolymphomas and related disorders. Springer, Berlin Heidelberg New YorkGoogle Scholar
  13. Dattwyler RJ, Volkman DJ, Halperin JJ, Luft BJ, Thomas JA, Golightly MG (1988) Specific immune responses in Lyme borreliosis: characterization of T cell and B cell responses to Borrelia burgdorferi. Ann NY Acad Sci 539:93–102PubMedCrossRefGoogle Scholar
  14. De Koning J, Hoogkamp-Korstanje JAA (1986) Diagnosis of Lyme disease by demonstration of spirochetes in tissue biopsies. Zentralbl Bakteriol Mikrobiol Hyg (A) 263:179–188Google Scholar
  15. Hardin JA, Steere AC, Malawista SE (1979) Immune complexes and the evolution of Lyme arthritis: dissemination and localization of abnormal Clq binding activity. N Engl J Med 301:1358–1363PubMedCrossRefGoogle Scholar
  16. Hauser W (1965) Wahrscheinliche Infektionskrankheiten der Haut. In: Marchionini A, Götz H (eds) Infektionskrankheiten der Haut I. Springer, Berlin Heidelberg New York, pp 555–629 (Handbuch der Haut- und Geschlechtskrankheiten, vol IV, part 1 A)Google Scholar
  17. Hellerström S (1930) Erythema chronicum migrans Afzelii. Acta Derm Venereol (Stockh) 11:315–321Google Scholar
  18. Hollström E (1951) Successful treatment of erythema migrans Afzelius. Acta Derm Venereol (Stockh) 31:235–243Google Scholar
  19. Hollström E (1958) Penicillin treatment of erythema chronicum migrans Afzelius. Acta Derm Venereol (Stockh) 38:285–289Google Scholar
  20. Kuiper H, de Jongh B, Ramselaar T, Spanjaard L (1990) Evidence of asymptomatic nervous system involvement in localized erythema migrans (abstract). IVth international conference on Lyme borreliosis, Stockholm, June 1990Google Scholar
  21. Lipschütz B (1913) Über eine seltene Erythemform (Erythema chronicum migrans). Arch Dermatol Syph 118:349–356CrossRefGoogle Scholar
  22. Moffat CM, Sigal LH, Steere AC, Freeman DH, Dwyer JM (1984) Cellular immune findings inLyme disease: correlation with serum IgM and disease activity. Am J Med 77:625–632PubMedCrossRefGoogle Scholar
  23. Neubert U, Krampitz HE, Engl H (1986) Microbiological findings in erythema chronicum migrans, acrodermatitis chronica atrophicans and lymphadenosis cutis benigna. Zentralbl Bakteriol Mikrobiol Hyg (A) 263:237–252Google Scholar
  24. Neumann R, Aberer E, Stanek G (1986) Treatment and course of erythema chronicum migrans. Zentralbl Bakteriol Mikrobiol Hyg (A) 263:372–376Google Scholar
  25. Putkonen T, Mustakallio KK, Salminen A (1962) Erythema chronicum migrans with meningitis: a rare coincidence of two tick-borne diseases? Dermatologica 125:184–188PubMedCrossRefGoogle Scholar
  26. Riehl G (1913) Arch Dermatol Syph 115:401CrossRefGoogle Scholar
  27. Schaad UB, Flüeler U, Schaub H et al. (1986) Durch Ixodes-ricinus-Sphochätm (Borrelia burgdorferi) verursachte Krankheitsbilder (Lyme-Krankheit) bei pädiatrischen Patienten in der Schweiz. Schweiz Med Wochenschr 116:1426–1430PubMedGoogle Scholar
  28. Sedlacek V (1960) Erythema chronicum migrans - poznamky ke klinice, etiopatogenezi a zara- zeni. Cs Dermatol 35:386–399Google Scholar
  29. Shresta M, Grodzicki RL, Steere AC (1985) Diagnosing early Lyme disease. Am J Med 78:235–240CrossRefGoogle Scholar
  30. Sonck CE (1965) Erythema chronicum migrans with multiple lesions. Acta Derm Venerol (Stockh) 45:34–36Google Scholar
  31. Stadelmann R (1934) Ein Beitrag zum Krankheitsbild des Erythema chronicum migrans Lipschütz. Dissertation, University of MarburgGoogle Scholar
  32. Stanek G, Pletschette M, Flamm H et al. (1988) European Lyme borreliosis. Ann NY Acad Sci 539:274–282PubMedCrossRefGoogle Scholar
  33. Steere AC (1989) Lyme disease. N Engl J Med 321:586–596PubMedCrossRefGoogle Scholar
  34. Steere AC, Malawista SE, Hardin JA, Ruddy S, Askenase PW, Andiman WA (1977) Erythema chronicum migrans and Lyme arthritis: the enlarging clinical spectrum. Ann Intern Med 86:685–698PubMedGoogle Scholar
  35. Steere AC, Hardin JA, Ruddy S, Mummaw JG, Malawista SE (1979) Lyme arthritis: correlation of serum and cryoglobulin IgM with activity, and serum IgG with remission. Arthritis Rheum 22:471–483PubMedCrossRefGoogle Scholar
  36. Steere AC, Bartenhagen NH, Craft JE et al. (1983) The early clinical manifestations of Lyme disease. Ann Intern Med 99:76–82PubMedGoogle Scholar
  37. Stiernstedt G, Eriksson W, Enfors H etal. (1986) Erythema chronicum migrans in Sweden. Scand J Infect Dis 18:217–224PubMedCrossRefGoogle Scholar
  38. Vaillant-Rieder L, Hey D (1987) Atypischer Verlauf einer Erythema-migrans-Krankheit. Dtsch Med Wochenschr 112:1680–1681PubMedGoogle Scholar
  39. Weber K (1986) Remarks on the infectious disease caused by Borrelia burgdorferi. Zentralbl Bakteriol Mikrobiol Hyg (A) 263:206–208Google Scholar
  40. Weber K (1989) Clinical differences between European and North-American Lyme borreliosis - a review. Zentralbl Bakteriol (Suppl) 18:146–155Google Scholar
  41. Weber K, Braun-Falco O (1974) Blutbildveränderungen bei Erythema chronicum migrans. Hautarzt 25:611–613PubMedGoogle Scholar
  42. Weber K, Neubert U (1986) Clinical features of early erythema migrans disease and related disorders. Zentralbl Bakteriol Mikrobiol Hyg (A) 263:209–228Google Scholar
  43. Weber K, Puzik A, Becker T (1983) Erythema-migrans-Krankheit: Beitrag zur Klinik und Beziehung zur Lyme-Krankheit. Dtsch Med Wochenschr 108:1182–1190PubMedCrossRefGoogle Scholar
  44. Weber K, Schierz G, Wilske B, Preac-Mursic V (1984a) European erythema migrans disease and related disorders. Yale J Biol Med 57:463–471PubMedGoogle Scholar
  45. Weber K, Schierz G, Wilske B, Preac-Mursic V (1984b) Zur Klinik und Ätiologie der Acrodermatitis chronica atrophicans. Hautarzt 35:571–577PubMedGoogle Scholar
  46. Weber K, Neubert U, Thurmayr R (1986a) Antibiotic therapy in early erythema migrans disease and related disorders. Zentralbl Bakteriol Mikrobiol Hyg (A) 263:377–388Google Scholar
  47. Weber K, Schierz G, Wilske B, Neubert U, Krampitz HE, Barbour AG, Burgdorfer W (1986b) Reinfection in erythema migrans disease. Infection 14:32–35PubMedCrossRefGoogle Scholar
  48. Weber K, Preac-Mursic V, Neubert U, Thurmayr R, Herzer P, Wilske B, Schierz G, Marget W (1988) Antibiotic therapy of early European Lyme borreliosis and acrodermatitis chronica atrophicans. Ann NY Acad Sci 539:324–345PubMedCrossRefGoogle Scholar
  49. Weber K, Preac-Mursic V, Wilske B, Thurmayr R, Neubert U, Scherwitz C (1990) A randomized trial of ceftriaxone versus oral penicillin for the treatment of early European Lyme borreliosis. Infection 18:91–96PubMedCrossRefGoogle Scholar
  50. Wegelin C (1947) Zur Histologie des Zeckenstiches. Dermatologica 94:368–376PubMedCrossRefGoogle Scholar
  51. WHO Case Definition Committee (Asbrink E, Hovmark A, Weber K) (1989) Cutaneous manifestations of Lyme borreliosis. Zentralblatt Bakt (Suppl) 18:350Google Scholar
  52. Williams CL, Curran AS, Lee AC, Sousa VO (1986) Lyme disease: epidemiologic characteristics of an outbreak in Westchester county, NY. Amer J Publ Health 76:62–65CrossRefGoogle Scholar
  53. Wilske B, Schierz G, Preac-Mursic V, Weber K, Pfister HW, Einhäupl K (1984) Serological diagnosis of erythema migrans disease and related disorders. Infection 12:331–337PubMedCrossRefGoogle Scholar
  54. Wilske B, Schierz G, Preac-Mursic V, Pfister HW, Weber K, von Busch K, Baruschke A (1989) IgM- and IgG-immune response to Borrelia burgdorferi in erythema migrans and neuroborre- liosis. Zentralbl Bakteriol (Suppl) 18:290–298Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • K. Weber
  • U. Neubert
  • S. A. Büchner

There are no affiliations available

Personalised recommendations