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Lipid Peroxidation and Antioxidants in Childhood Epilepsy

  • A. O. Ogunmekan
  • P. A. Hwang

Summary

Evidence linking vitamin E deficiency with neurological abnormalities indicates that vitamin E may have an important central nervous system role relating to membrane stability and function. In an experimental model, vitamin E (α-tocopheryl acetate) reduced seizure activity. Vitamin E inhibits the effects of oxidation in brain tissues (antioxidant) and is a free radical scavenger. Free radical scavengers have been implicated in the epileptic brain injury caused by prolonged seizures due to hyperoxia. Vitamin E is a membrane stabilizer protecting membranes from peroxidation damage. Clinical studies in children have shown reduced plasma levels of vitamin E in seizure patients receiving antiepileptic drugs (AEDs). An uncontrolled, non-blind clinical trial suggested that add-on vitamin E improved seizure control in some patients. Since vitamin E deficiency hypothetically exacerbates epileptic seizures in patients receiving AEDs, treatment of the vitamin E deficiency should improve seizure control and/or neurological function. A prospective, modified crossover, randomized, double-blind, placebo-controlled clinical trial of add-on vitamn E therapy (400 IU/day) was then carried out in 24 epileptic patients who were refractory to AEDs. There was a significant reduction of seizures in 10 of 12 patients. This result was significantly different from that with controls given placebo (0 of 12, p < 0.05).This result did not appear to be due to the effects of change in the plasma levels of the co-medication. There were no adverse side effects. This therapeutic observation accords with previous reports and some experimental studies. This finding may be very important to the 10 %–20 % of the epileptic population whose seizures are inadequately controlled with the best anticonvulsant drugs presently available.

Keywords

Seizure Frequency Childhood Epilepsy Epileptic Child Improve Seizure Control Develop Status Epilepticus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • A. O. Ogunmekan
  • P. A. Hwang

There are no affiliations available

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