Neurobiologische Grundlagen der Zwangsstörung

  • Fritz Hohagen
Conference paper
Part of the Die Reihe dupbar med communication wird / Series dupbar med communication book series (dmc)


Hirnorganische Faktoren scheinen bei der Pathogenese der Zwangserkrankung eine große Rolle zu spielen, wobei eine funktionelle Störung im Zusammenspiel von Frontalhirn, limbischem System und Basalganglien vorzuliegen scheint. Dem serotonergen System kommt bei der Entstehung von Zwangssymptomen eine große Bedeutung zu. Ein so komplexes Krankheitsbild wie das der Zwangsstörung läßt sich jedoch nicht aus einem Neurotransmittersystem allein erklären, sondern muß als Interaktion psychologischer und biologischer Faktoren verstanden werden.

Genetische Befunde aus Familien- und Zwillingsstudien werden berichtet, klinische Beobachtungen von Zwangssymptomen, die mit verschiedenen neurologischen Erkrankungen einhergehen, werden diskutiert.

Ergebnisse neuropsychologischer und neurochirurgischer sowie PET-Untersuchungen an Patienten mit Zwangsstörungen werden erläutert.

Neurobiological Bases of Obsessive-Compulsive Disorder


Brain organic factors seem to play an important role in the pathogenesis of obsessive-compulsive disorder (OCD), in which there seems to be a functional disorder in the interaction of frontal brain, limbic system, and basal ganglia. The serotonergic system is of utmost importance in the emergence of obsessive-compulsive symptoms. A syndrome as complex as OCD cannot, however, be explained by neurotransmitter systems alone but has to be regarded as an interaction of psychological and biological factors.

A report of the genetic findings of family and twin studies and a discussion on clinical observations of obsessive-compulsive symptoms in patients with neurological disorders are presented here.

A comment on the results of neuropsychological, neurosurgical, and PET-studies in patients with obsessive-compulsive disorders will also be given.


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© Springer-Verlag Berlin Heidelberg 1992

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  • Fritz Hohagen

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