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Experimental Studies of Humoral and Cellular Immunological Parameters of Viral Heart Disease

  • B. Maisch
  • M. Herzum

Abstract

Realisation and expectation, hopes and frustration in the diagnosis, the pathogenetic understanding and the treatment of viral heart disease in general and viral myocarditis in particular can be appreciated best from a historical retrospective, from which current perspectives will become clearer.

Keywords

Dilate Cardiomyopathy Infective Endocarditis Endomyocardial Biopsy Viral Myocarditis Acute Myocarditis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Abelmann WH, Kowalski HJ, McNeely WF (1954) Cardiovascular studies during acute infectious hepatitis. Gastroenterology 27: 61–66PubMedGoogle Scholar
  2. 2.
    Acosta AM, Sadigursky M, Santos-Bush CA (1983) Anti-striated muscle antibody activity produced by Trypanosoma cruzi. Proc Soc Exp Biol Med 172: 364–374PubMedGoogle Scholar
  3. 3.
    Adams CW (1959) Post-viral myopericarditis associated with the influenza virus: report of eight cases. Am J Cardiol 4: 56–67PubMedGoogle Scholar
  4. 4.
    Ahvenainen EK (1952) Inclusion disease or generalized salivary gland virus infection: report of five cases. Acta Pathol Microbiol Scand 93 Suppl: 159–167Google Scholar
  5. 5.
    Ainger LE, Lawyer NG, Fitch CW (1966) Neonatal rubella myocarditis. Br Heart J 28: 691–697PubMedGoogle Scholar
  6. 6.
    Alvarez FL, Neu N, Rose NR, Craig SW, Beisel KW (1987) Heart-specific autoantibodies induced by coxsackievirus B: identification of heart autoantigens. Clin Immunol Immunopathol 43: 12–23Google Scholar
  7. 7.
    Anderson JL, Carlquist JF, Hammond EH (1982) Deficient natural killer cell activity in patients with idiopathic dilated cardiomyopathy. Lancet 2: 1124–1127PubMedGoogle Scholar
  8. 8.
    Anderson T, Foulis MA, Grist NR, Landsman JB (1951) Clinical and laboratory observations in a smallpox outbreak. Lancet I: 1248–1252Google Scholar
  9. 9.
    Aretz Ht, Billingham ME, Edward WD (1987) Myocarditis: a histological definition and classification. Am J Cardiovasc Pathol 1: 3–13PubMedGoogle Scholar
  10. 10.
    Avrameas S (1986) Natural autoreactive B cells and autoantibodies: the know thyself of the immune system. Ann immunol (Paris) 137: 150–153Google Scholar
  11. 11.
    Banatvala JE (1983) Coxsackie B virus infections in cardiac disease. In: Waterson AP (ed) Recent advances in clinical virology vol. 3. Churchill Livingstone, Edinburgh, pp 99–115Google Scholar
  12. 12.
    Banatvala JE, Bryant J, Schernthaner G, Borkenstein M, Schober E, Brown D, de Solva LM, Mensa MA, Silink M (1985) Coxsackie B, mumps, rubella and cytomegalovirus-specific 1gM responses in patients with juvenile onset insulin-dependent diabetes mellitus in Britain, Austria and Australia. Lancet 1: 1409–1412Google Scholar
  13. 13.
    Beisel KW (1989) Immunogenetic basis of myocarditis: role of fibrillary antigens. Springer Semin Immunopathol 11: 31–42PubMedGoogle Scholar
  14. 14.
    Beisel KW, Chow LH, Booth BJM, Nesbitt MN, McManus BM (1989) Linkage of susceptibility to autoimmune-based viral myocarditis with Tcra and Myhc-a loci on murine chromosome 14 (Abstr). Circulation 80 Suppl 2: 2673Google Scholar
  15. 15.
    Beisel K, Wolfgram L, Herskowitz A, Rose N (1991) Differences in severity of Coxsackievirus B3-induced myocarditis among H-2 congenic mouse strain. In: Skameme E (ed) Genetic control of host resistance to infection and malignancy, vol 3. Liss, New York, pp 195–205Google Scholar
  16. 16.
    Bell EJ, Grist NR (1968) Coxsackie virus infections in patients with acute cardiac disease and chest pain. Scott Med J 13: 47–51PubMedGoogle Scholar
  17. 17.
    Bengtsson E, Örndahl G (1954) Complications of mumps with special reference to the incidence of myocarditis. Acta Med Scand 149: 381–388PubMedGoogle Scholar
  18. 18.
    Berkovich S, Rodriguez-Torres R, Lin TS (1968) Virologic studies in children with acute myocarditis. Am J Dis Child 115: 207–212PubMedGoogle Scholar
  19. 19.
    Besteri RB (1989) Cardiac involvement in the acquired immune deficiency syndrome. J Cardiol 22: 143–146Google Scholar
  20. 20.
    Billingham ME, Mason JW (1984) Endomyocardial biopsy changes in myocarditis treated with immunosuppressives. In: Bolte H-D (ed) Viral heart disease. Springer, Berlin Heidelberg New York, pp 200–210Google Scholar
  21. 21.
    Bodey GP, Wertlake PT, Douglas G, Levin RH (1965) Cytomegalic inclusion disease in patients with acute leukemia. Ann Intern Med 62: 899–906PubMedGoogle Scholar
  22. 22.
    Bolte HD, Schultheiss P, Cyran J, Goss F (1980) Binding of immunoglobulins in the myocardium biopsy. In: Bolte H-D (ed) Myocardial biopsy. Springer, Berlin Heidelberg New York, pp 85–92Google Scholar
  23. 23.
    Bowles NE, Richardson PJ, Olsen EGJ, Archard LC (1986) Detection of Coxsackie B-virus-specific RNA sequences in myocardial biopsy samples from patients with myocarditis and dilated cardiomyopathy. Lance l: 1120–1123Google Scholar
  24. 24.
    Boyden SV (1963) Natural antibodies and the immune response. Adv Immunol 5: 1–7Google Scholar
  25. 25.
    Bresnihan B, Jasin ME (1977) Suppressor function of peripheral blood mononuclear cells in normal individuals and in patients with systemic lupus erythematosus. J Clin Invest 59: 106–116PubMedGoogle Scholar
  26. 26.
    Bugher JC (1951) The pathology of yellow fever. In: Stoker GK (ed) Yellow fever. McGraw-Hill, New York, pp 137–163Google Scholar
  27. 27.
    Buie C, Lodge PA, Herzum M, Huber SA (1987) Genetics of Coxsackie virus B3 and encephalomyocarditis virus-induced myocarditis in mice. Eur Heart J 8 Suppl J: 389–401Google Scholar
  28. 28.
    Bülowius H, Maisch B, Klopf D, Schmier K, Hiby A, Schunk D, Kochsiek K (1983) Lymphozytensubpopulationen Bei akuter Perimyokarditis, sekundären and primären dilatativen Herzmuskelerkrankungen. Z Kardiol 72 Suppl 1: 16Google Scholar
  29. 29.
    Burch GE, Giles TG (1972) The role of viruses in the production of heart disease. Am J Cardiol 29: 231–240PubMedGoogle Scholar
  30. 30.
    Caldera R, Sarrut S, Mallet R, Rossier A (1961) Existe-t-il des complications cardiaques de la vaccine? Sem Hop Paris 37: 1281–1284Google Scholar
  31. 31.
    Cambridge G, MacArthur CGC, Waterson AP, Goodwin JF, Oakley C (1979) Antibodies to Coxsackie B viruses in congestive cardiomyopathy. Br Heart J 16: 692–696Google Scholar
  32. 32.
    Cambridge G, Campbell-Blay G, Wilmhurst P, Coltart DJ, Stern CMM (1983) Deficient “natural” cytotoxicity in patients with congestive cardiomyopathy ( Abstr ). Br Heart J 49: 623Google Scholar
  33. 33.
    Cannell DE (1928) Myocardial degenerations in yellow fever. Am J Pathol 4:431–443 33a. Cheetham HD, Hart J, Coghill NF, Fox Z ( 1970 ) Rabies with myocarditis, two cases in England. Lancet I: 921–922Google Scholar
  34. 34.
    Christian HA (1951) Nearly ten decades of interest in idiopathic pericarditis. Am Heart J 42: 645–651PubMedGoogle Scholar
  35. 35.
    Coltman CA Jr (1962) Influenza myocarditis: report of a case with observations on serum glutamic oxaloacetic transaminase. JAMA 180: 204–208PubMedGoogle Scholar
  36. 36.
    Craighead JE, Huber SA, Martin WB (1991) Murine cytomegalovirus myocarditis. Eur Heart J 12 Suppl D: 69–72Google Scholar
  37. 37.
    Cunningham MW, Swerlick RA (1986) Polyspecificity of antistreptococcal murine monoclonal antibodies and their implication in autoimmunity. J Exp Med 164: 998–1004PubMedGoogle Scholar
  38. 38.
    Cunningham MW, Hall NK, Krisher KK, Spanier AM, (1986) A study of anti-group a streptococcal monoclonal antibodies cross-reactive with myosin. J Immunol 136: 293–298PubMedGoogle Scholar
  39. 39.
    Dale JB, Beachey EH (1986) Sequence of myosin-crossreactive epitopes of streptococcal M protein. J Exp Med 164: 1785–1789PubMedGoogle Scholar
  40. 40.
    Dalgaard JB (1957) Fatal myocarditis following smallpox vaccination. Am Heart J 54: 156–158PubMedGoogle Scholar
  41. 41.
    Daly K, Richardson PJ, Olsen EGJ, Morgan-Capner P, McSorley C, Jackson G, Jewitt DE (1984) Acute myocarditis: role of histological and virological examination in the diagnosis and assessment of immunosuppressive treatment. Br Heart J 51: 30–35PubMedGoogle Scholar
  42. 42.
    Das SK, Callen JP, Doson VN, Cassidy JT (1971) Immunoglobulin binding in cardiomyopathic hearts. Circulation 44: 612–621PubMedGoogle Scholar
  43. 43.
    Das SK, Petty RE, Meengs WA, Tubergen DG (1980) Studies of cell-mediated immunity in cardiomyopathy. In: Sekiguchi M, Olsen EGJ (eds) Cardiomyopathy. University of Tokyo Press, Tokyo, pp 375–377Google Scholar
  44. 44.
    De Crombrugghe B, Lau G, Setoyama C, Schmidt A, McKeon C, Mudry M (1985) Structural and foundational studies on interstitial collagen genes. In: Evered D, Whelan J (eds) Fibrosis. Pitman, London, pp 20–32Google Scholar
  45. 45.
    Deck WG, Palacios IF, Fallon JT, Aretz HT, Mills J, Lee DCS, Johnson RA (1985) Active myocarditis in the spectrum of acute dilated cardiomyopathies. N Engl J Med 342: 885–897Google Scholar
  46. 46.
    Dell A, Antone SM, Gauntt CJ, Crossley CA, Clark WA, Cunningham MW (1991) Autoimmune determinants of rheumatic carditis: localization of epitopes in human cardiac myosin. Eur Heart J 12 Suppl D: 158–162Google Scholar
  47. 46a.
    De Scheerder, de Buyzere M, Algoed L, de Lange M, de Langhe J, Bogaert AM, Clement DL (1987) Characteristics anti-heart antibody patterns in post-cardiac injury syndrome endocarditis and acute myocarditis. Eur Heart J 8 Suppl I: 237–238Google Scholar
  48. 47.
    Doerr W (1971) Morphologie der Myokarditis. Verh Dtsch Ges Inn Med 77: 301–335PubMedGoogle Scholar
  49. 48.
    Dolgopol VB, Cragen MD (1948) Myocardial changes in poliomyelitis. Arch Pathol 46: 202–211Google Scholar
  50. 49.
    Drude L, Wiemers F, Maisch B (1991) Impaired myocyte function in vitro incubated with sera from patients with myocarditis. Eur Heart J 12 Suppl D: 36–38Google Scholar
  51. 50.
    Eckstein R, Mempel W, Bolte H-D (1982) Reduced suppressor cell activity in congestive cardiomyopathy and in myocarditis. Circulation 65: 1224–1229PubMedGoogle Scholar
  52. 51.
    Eghbali M, Czaja MJ, Chepko G, Hem MA, Seifter S, Blumenfeld 00 (1987) Differential collagen gene expression in heart cells. Fed Proc 46: 2040Google Scholar
  53. 52.
    Eghbali ME, Egbali M, Robinson TF, Seifter S, Blumenfeld 00 (1987) Role of fibroblasts in the accumulation of collagens in growing and adult rat hearts. J Mol Cell Cardiol 19 Suppl 4: 854Google Scholar
  54. 53.
    Fenoglio JJ Jr, Ursell PC, Kellogg CF, Drusin RE, Wiss MB (1983) Diagnosis and classification of myocarditis by endomyocardial biopsy. N Engl J Med 308: 12–18PubMedGoogle Scholar
  55. 54.
    Finland M, Parker F Jr, Barnes MW, Joliffe LS (1945) Acute myocarditis in influenza infections: two cases of non-bacterial myocarditis with isolation of virus from the lungs. Am J Med Sci 209: 455–468Google Scholar
  56. 55.
    Fletcher E, Brennan CF (1957) Cardiac complications of Coxsackie virus infection. Lancet 1: 913–915Google Scholar
  57. 56.
    Fletcher GF, Coleman MT, Feorius PM, Marine WM, Wenger NK (1968) Viral antibodies in patients with primary myocardial disease. Am J Cardiol 21: 6–14PubMedGoogle Scholar
  58. 57.
    Fowles RE, Bieber CP, Stinson EB (1978) Defective in vitro suppressor cell function in idiopathic congestive cardiomyopathy. Circulation 59: 483–491Google Scholar
  59. 58.
    Francesini R, Petillo A, Corazza M, Nizzo MC, Azzolini A, Gianrossi R (1983) Lymphocyte response in dilated cardiomyopathy. IRCS Med Sci 2: 1019–1021Google Scholar
  60. 59.
    Friedman I, Laufer A (1976) Electron microscopical studies of the effect of antiheart antibodies and complement on beating heart cells in culture. J Mol Cell Cardiol 8: 641–650PubMedGoogle Scholar
  61. 60.
    Friedman I, Laufer A, Ron N, Davies AM (1971) Experimental myocarditis: in vitro and in vivo studies of lymphocytes sensitized to heart extracts and group A streptococci. J Immunol 20: 225–232Google Scholar
  62. 61.
    Fuchs E, Hanukoglu C (1983) Unraveling the structure of the intermediate filaments. Cell 34: 332–342PubMedGoogle Scholar
  63. 62.
    Gardinger AJS, Short D (1973) Four faces of acute myopericarditis. Br Heart J 35: 433–442Google Scholar
  64. 63.
    Gauntt CJ, Goeny EK, Lutton CM, Pernandes G (1989) Role of natural killer cells in experimental murine myocarditis. Springer Semin Immunopathol 11: 51–59PubMedGoogle Scholar
  65. 64.
    Geisler N, Kaufman E, Weber K (1971) Protein chemical characterization of three structurally distinct domains along the protofilament unit of the desmin 10-mm filaments. Cell 30: 277–281Google Scholar
  66. 65.
    Giles C, Shuttleworth EM (1957) Postmortem findings in 46 influenza deaths. Lancet 2: 1224–1225Google Scholar
  67. 66.
    Giustra FX, Nilsson DC (1950) Myocarditis following measles. Am J Dis Child 79: 487–490Google Scholar
  68. 67.
    Godeney EK, Gauntt CJ (1987) Murine natural killer cells limit Coxsackievirus B3 replication. J Immunol 139: 913–918Google Scholar
  69. 68.
    Goldstein MA, Entman ML (1979) Microtubules in-mammalian heart muscle. J Cell Biol 80: 183–189PubMedGoogle Scholar
  70. 69.
    Gore I, Kline IK (1968) Pericarditis and myocarditis. In: Gould SE (ed) Pathology of the heart and blood vessels, 3rd edn Thomas, Springfield, pp 731–759Google Scholar
  71. 70.
    Gore I, Saphir 0 (1947) Myocarditis: a classification of 1402 cases. Am Heart J 34: 827–830Google Scholar
  72. 71.
    Grist NR, Bell EJ (1969) Coxsackie viruses and the heart. Am Heart J 77: 295–300PubMedGoogle Scholar
  73. 72.
    Grist NR, Bell EJ (1974) A six year study of Coxsackie virus B infections in heart disease. J Hyg (Carob) 73: 165–174Google Scholar
  74. 73.
    Grody WW, Cheng L, Pang, M, Lewis W (1989) Direct infection of the heart by human immunodeficiency virus (HIV) (Abstr). Circulation 80 Suppl 2: 2644Google Scholar
  75. 74.
    Hackel DB (1953) Myocarditis in association with varicella. Am J Pathol 29: 369–379PubMedGoogle Scholar
  76. 75.
    Hallgren HM, Yunis EJ (1977) Suppressor lymphocytes in young and aged humans. J Immunol 118: 2004–2008PubMedGoogle Scholar
  77. 76.
    Hamburger WW (1938) The heart in influenza. Med Clin North Am 22: 111–121Google Scholar
  78. 77.
    Hammond EH, Menlove RL, Anderson JL (1988) Immunofluorescence microscopy in the diagnosis and follow-up of patients suspected of having inflammatory heart disease. In: Schultheiss HP (ed) New concepts in viral heart disease: virology, immunology and clinical management. Springer, Berlin Heidelberg New York pp 303–311Google Scholar
  79. 78.
    Harding SE, MacLeod KT, Jones SM, Vescovo G, Poole-Wilson PA (1991) Contractile responses of myocytes isolated from patients with cardiomyopathy. Eur Heart J 12 Suppl D: 44–49Google Scholar
  80. 79.
    Haskowa V, Holub M, Hasek J (1987) Changes in the microtubular skeleton of human lymphocytes produced by immunosuppressive substances. Czech Med 10: 164–169Google Scholar
  81. 80.
    Hauck AJ, Kearney DL, Edwards WS (1989) Evaluation of postmortem endomyocardial biopsy specimens from 38 patients with lymphocytic myocarditis: implications for role of sampling error. Mayo Clin Proc 64: 1235–1245PubMedGoogle Scholar
  82. 81.
    Hay ED (1981) Extracellular matrix. J Cell Biol 91: 205–217Google Scholar
  83. 82.
    Hay Ed (1982) Cell biology of extracellular matrix. Plenum, New YorkGoogle Scholar
  84. 83.
    Hengstenberg C, Rose M, Olsen E, Richardson PJ, Archard L, Yacoub M (1989) Immonological parameters in patients with different heart diseases (Abstr) Eur Heart J 10 Suppl: 27Google Scholar
  85. 84.
    Henson D, Mufson MA (1971) Myocarditis and pneumonitis with type 21 adenovirus infection: association with fatal myocarditis and pneumonitis. Am J Dis Child 121: 433–422Google Scholar
  86. 85.
    Herskowitz A, Beisel KW, Wolfgram LJ, Rose NR (1985) Coxsackievirus B3 murine myocarditis: wide pathologic spectrum in genetically defined inbred strains. Hum Pathol 16: 671–678PubMedGoogle Scholar
  87. 86.
    Herskowitz A, Wolgram LJ, Rose NR, Beisel KW (1987) Coxsackievirus B3 murine myocarditis: a pathologic spectrum of myocarditis in genetically defined inbred strains. J Am Cell Cardiol 9: 1311–1329Google Scholar
  88. 87.
    Herskowitz A, Neumann DA, Rose NR, Beschorner WE, Sell KI, Ansari AA, Baughman KL (1989) Histocompatibility (MHC) antigens in human myocarditis: new markers of immunemediated disease (Abstr). Circulation 80 Suppl 2: 2686Google Scholar
  89. 88.
    Herzum M, Maisch B (1989) Anti-viral and anti-myocyte antibodies in experimental myocarditis. Springer Semin Immunopathol 11: 69–76PubMedGoogle Scholar
  90. 89.
    Herzum M, Maisch B, Kochsiek K (1987) Circulating immune complexes in perimyocarditis and infective endocarditis. Eur Heart J 8 Suppl J: 323–326Google Scholar
  91. 90.
    Herzum M, Huber SA, Maisch B (1988) Coxsackie B3 myocarditis: genetic aspects of different immunopathogenic mechanisms in Balb/c and DBA/2 mices. Antigenic specificity of heart-reactive antibodies in DBA/2 mices. In: Schultheiss HP (ed) New concepts in viral heart disease. Springer, Berlin Heidelberg New York, pp 188–194Google Scholar
  92. 91.
    Hirschmann SZ, Hammer GS (1974) Coxsackie virus myopericarditis: a microbiological and clinical review. Am J Cardiol 34: 224–232Google Scholar
  93. 92.
    Hoagland RJ (1956) Cardiac involvement in infectious mononucleosis. Am J Med Sci 232: 252–257PubMedGoogle Scholar
  94. 93.
    Huber SA, Lodge PA (1984) Coxsackie B3 myocarditis: identification of different pathogenic mechanisms in DBA/2 and Balb/c mice. Am J Pathol 122: 284–291Google Scholar
  95. 94.
    Huber SA, Lodge PA (1984a) Coxsackievirus B3 myocarditis in BALB/c mice: evidence for autoimmunity to myocyte antigens. Am J Pathol 116: 21–29PubMedGoogle Scholar
  96. 95.
    Huber SA, Job LP, Woodruff JF (1980) Lysis of infected myofibres by Coxsackie virus B3 immune T-lymphocytes. Am J Pathol 98: 681–694PubMedGoogle Scholar
  97. 96.
    Huber SA, Simpson K, Weller A, Herzum M (1988) Immunopathogenic mechanisms in experimental myocarditis: evidence for autoimmunity to the virus receptor and antigenic mimicry between the virus and the myocardium. In: Schultheiss HP (ed) New concepts in viral heart disease. Springer Berlin Heidelberg New York, pp 179–187Google Scholar
  98. 97.
    Hufnagel G, Maisch B (1989) MHC antigen expression in endomyocardial biopsies in patients with myocarditis and dilated cardiomyopathy (Abstr). Eur Heart J 10 Suppl: 28Google Scholar
  99. 98.
    Hufnagel G, Pfeifer U, Maisch B (1987) Immunohistological investigation in suspected cardiac sarcoidosis. Eur Heart J 8: Suppl J 59–62Google Scholar
  100. 99.
    Hynes RO (1985) Molecular biology of Gbronectin. Annu Rev Cell Biol I: 67–79Google Scholar
  101. 100.
    Hynes RO, Yamada S (1982) Fibronectins: multifunctional nodular glycoprotein. J Cell Biol 95: 369–376PubMedGoogle Scholar
  102. 101.
    Izumi T, Kodama M, Shibata A (1991) Experimental giant cell myocarditis induced by cardiac myosin immunization. Eur Heart J 12 Suppl D: 166–168Google Scholar
  103. 102.
    Jacobs B, Matsuda Y, Deodhar S (1979) Cell-mediated cytotoxicity to cardiac cells of lymphocytes from patients with primary myocardial disease. Am J Clin Pathol 72: 1–4PubMedGoogle Scholar
  104. 103.
    James TN (1983) Myocarditis and cardiomyopathy. N Engl J Med 308: 39–41PubMedGoogle Scholar
  105. 104.
    James TM, Umamura K (1981) Virus-like particles associated with intracardiac ganglionitis in two cases of sudden unexpected death. Jpn Heart J 22: 447–454PubMedGoogle Scholar
  106. 105.
    Javett SN, Heymann S, Mundel B, Peler WL, Lurie HJ, Gear J, Measroch V, Kirsch Z (1956) Myocarditis in new born infant: a study of an outbreak associated with Coxsackie group B virus infection in a maternity home in Johannesburg. J Padiatr 48: 1–22Google Scholar
  107. 106.
    Jennings RC (1966) Coxsackie group B fatal neonatal myocarditis associated with cardiomegaly. J Clin Pathol 19: 325–327PubMedGoogle Scholar
  108. 107.
    Jerne NK (1955) The natural selection theory of antibody formation. Proc Natl Acad Sci USA 41: 849–857PubMedGoogle Scholar
  109. 108.
    Kandolf R, Hofschneider PH (1989) Viral heart disease. Springer Semin Immunopathol 11: 1–13PubMedGoogle Scholar
  110. 109.
    Kandolf R, Ameis D, Kirschner P, Canu A, Hofschneider PH (1987) In situ detection of enteroviral genomes in myocardial cells: an approach to the diagnosis of viral heart disease. Proc Nati Acad Sci USA 84: 6272–6276Google Scholar
  111. 110.
    Kaplan MH (1967) Multiple nature of the cross-reactive relationships between antigens of group A streptococci and mammalian tissue. In: Trentin JJ (ed) Cross-reaction, antigens and neoantigens. Williams and Wilkins, Baltimore, pp 48–55Google Scholar
  112. 111.
    Katz AM, Messineo FC, Herbette L (1985) Membrane damage in the pathogenesis of cardiomyopathies. J Mol Cell Cardiol Suppl 2: 17: 11–17Google Scholar
  113. 112.
    Kawai C, Matsumori A, Kitaura Y, Takatsu T (1978) Viruses and the heart: viral myocarditis and cardiomyopathy. In: Yu PN, Goodwin JF (eds) Progress in cardiology. Lea and Febiger, Philadelphia, pp 141–162Google Scholar
  114. 113.
    Kawai S, Okada R (1987) A histopathological study of dilated cardiomyopathy: with special reference to clinical and pathological comparisons of the degeneration-predominant type and fibrosis-predominant type. Jpn Circ J 51: 654–660PubMedGoogle Scholar
  115. 114.
    Kefalides NA, Alper R, Clarc CC (1979) Biochemistry and metabolism of basement membranes. Int Rev Cytol 61: 67–75Google Scholar
  116. 115.
    Kibrick S, Benirschke K (1956) Acute aseptic myocarditis and meningoencephalitis in the newborn child infected with Coxsackie virus group B, type 3. N Engl J Med 255: 883–889PubMedGoogle Scholar
  117. 116.
    Kipkie GF, McAuley JSM (1954) Acute myocarditis occurring in bulbar poliomyelitis. Can Med Assoc J 70: 315–317PubMedGoogle Scholar
  118. 117.
    Kirsner AB, Hess EV, Fowler NO (1973) Immunologic findings in idiopathic cardiomyopathy. Am Heart J 86: 625–630PubMedGoogle Scholar
  119. 118.
    Kishimoto C, Crumpacker CS, Abelman WH (1988) Ribavirin treatment of murine coxsackievirus B myocarditis with analyses of lymphocyte subsets. J Am Coll Cardiol 12: 1334–1342PubMedGoogle Scholar
  120. 119.
    Kishimoto C, Crumpacker CS, Abelman WH (1988) Prevention of murine Coxsackie B3 viral myocarditis and associated lymphoid organ atrophy with recombinant human leukocyte interferon alpha. Cardiovasc Res 22: 732–738PubMedGoogle Scholar
  121. 119a.
    Klappacher G, Pacher R, Woluszczuk W, Glogar D (1991) Increased release of neopterin and tumor necrosis factor alpha into the serum of patients with primary dilated cardiomyopathy (Abstr). Eur Heart J 12 Suppl: 315Google Scholar
  122. 120.
    Klappacher G, Pacher R, Woluszczuk W, Glogar D (1991) Elevated circulating levels of ß2-microglobulin in primary dilated cardiomyopathy (Abstr). Eur Heart J 12 Suppl: 316Google Scholar
  123. 121.
    Klein J, Stanek G, Bittner R, Horvat R, Holzinger C, Glogar D (1991) Lyme borreliosis as a cause of myocarditis and heart muscle disease. Eur Heart J 12 Suppl D: 73–75Google Scholar
  124. 122.
    Klein R, Maisch B, Kochsiek K, Berg PA (1984) Demonstration of organ specific antibodies against heart mitochondria (anti-M7) in sera from patients with some forms of heart disease. Clin Exp Immunol 58: 283–292PubMedGoogle Scholar
  125. 123.
    Klein R, Spiel L, Kleemann U, Hassenstein P, Berg PA (1987) Relevance of antimitochondrial antibodies (anti-M7) in cardiac disease. Eur Heart 8: J Suppl J 223–226Google Scholar
  126. 124.
    Kline IK, Saphir O (1960) Chronic pernicious myocarditis. Am Heart J 59: 681–684PubMedGoogle Scholar
  127. 125.
    Kühl U, Ulrich G, Schultheiss H-P (1987) Cross-reactivity of antibodies to the ADP/ATP translocator of the inner mitochondrial membrane with the cell surface of cardiac myocytes. Eur Heart J 8 Suppl J: 219–222Google Scholar
  128. 126.
    Kühl U, Ulrich G, Melzner B, Schöber, B, Morad M, Schultheiss HP (1989) Characterization of autoantibodies against of Ca’-channel inducing cytotoxicity by enhancement of calcium permeability. 7th International Congress of Immunology, July 30—Aug 5, BerlinGoogle Scholar
  129. 127.
    Kurnick JT, Leary C, Palacios IF, Fallon JT (1987) Culture and characterization of lymphocytic infiltrates from endomyocardial biopsies of patients with idiopathic myocarditis. Eur Heart J 8 Suppl J: 135–139Google Scholar
  130. 128.
    Kysal A, Haverich A, Heublein B, Kemnitz J, Gerogh A (1981) C-myc oncogene expression in myocytes in heart allografts. 7th International Congress of Immunology, July 30—Aug 5, BerlinGoogle Scholar
  131. 129.
    Laake H (1951) Myocarditis in poliomyelitis. Acta Med Scand 140: 159–169PubMedGoogle Scholar
  132. 130.
    Lazarides E (1976) Two general classes of cytoplasmic actin filaments in tissue culture cells: the role of tropomyosin. J Supramol Struct 5: 531–539PubMedGoogle Scholar
  133. 131.
    Lazarides E (1978) The distribution of desmin (100-A) filaments in primary cultures of embryonic chick cardiac cells. Exp Cell Res 11: 265–269Google Scholar
  134. 132.
    Lazarides E (1980) Intermediate filaments as mechanical integrators of cellular space. Nature 283: 249–256PubMedGoogle Scholar
  135. 133.
    Leatherbury L, Chandra RS, Shapiro SR, Perry LW (1988) Value of endomyocardial biopsy in infants, children and adolescents with dilated or hypertrophie cardiomyopathy and myocarditis. J Am Coll Cardiol 12: 1547–1554PubMedGoogle Scholar
  136. 134.
    Lerner AM, Wilson FM (1973) Virus myocardiopathy. Prog Med Virol 15: 63–91PubMedGoogle Scholar
  137. 135.
    Leroay EC (1985) Collagen disposition in autoimmune disease: the expanding role of the fibroblast in human fibriotic disease. In: Evered D, Whelan J (eds) Fibrosis. Pitman, London, pp 196–204Google Scholar
  138. 136.
    Leslie KO (1988) Progressive interstitial collagen deposition in Coxsackievirus B3-induced murine myocarditis (Abstr). International Symposium on inflammatory Heart Disease, July 27–31, SnowmassGoogle Scholar
  139. 137.
    Lewis W (1989) AIDS: cardiac findings from 115 biopsies. Prog Cardiovasc Dis 32: 207–215 137a. Lie JT (1988) Myocarditis and endomyocardial biopsy in unexplained Heart failure: a diagnosis in search of a disease. Ann Intern Med 109: 525–528Google Scholar
  140. 138.
    Limas CJ, Goldenberg IF (1987) Autoantibodies against cardiac beta-adrenoceptors in human dilated cardiomyopathy. Circulation 76 Suppl 4: 262–269Google Scholar
  141. 139.
    Limas CJ, Goldenberg IF, Limas C (1989) Autoantibodies against beta-adrenoceptors in human idiopathic dilated cardiomyopathy. Circ Res 64: 97–103PubMedGoogle Scholar
  142. 140.
    Lodge PA, Herzum M, Olszewski J, Huber SA (1987) Coxsackie B-3 myocarditis: acute and chronic forms of the disease caused by different immunopathogenic mechanisms. Am J Pathol 128: 455–463PubMedGoogle Scholar
  143. 142.
    Longson M, Cole FM, Davies C (1969) Isolation of Coxsackie virus group B, type 5, from the heart of a fatal case of myocarditis in an adult. J Clin Pathol 22: 654–658PubMedGoogle Scholar
  144. 143.
    Lotze U, Maisch B (1989) Humoral immune response to cardiac conducting tissue. Springer Semin Immunopathol 11: 409–422PubMedGoogle Scholar
  145. 144.
    Lowry PJ, Edwards CW, Nagle RE (1982) Herpes-like virus particles in myocardium of patient progressing to congestive cardiomyopathy. Br Heart J 48: 501–504PubMedGoogle Scholar
  146. 145.
    Lowry PJ, Thompson RA, Littler WA (1983) Humoral immunity in cardiomyopathy. Br Heart J 50: 390–394PubMedGoogle Scholar
  147. 146.
    Lowry PJ, Thompson RA, Littler WA (1984) Humoral and cellular mechanisms in congestive cardiomyopathy ( Abstr ). Br Heart J 51: 109Google Scholar
  148. 147.
    Ludden TE, Edward JE (1949) Carditis in poliomyelitis: an anatomic study of thirty-five cases and review of the literature. Am J Pathol 25: 357–381PubMedGoogle Scholar
  149. 148.
    Lundgren E, Terracio L, Borg TK (1985) Adhesion of cardiac myocytes to extracellular matrix components. Basic Res Cardiol 80 Suppl 1: 69–76Google Scholar
  150. 149.
    Maisch B (1984) Cytolytic serum activity in patients with carditis. In: Bolte HD (ed) Viral heart disease. Springer, Berlin Heidelberg New York, pp 121–130Google Scholar
  151. 150.
    Maisch B (1984) Diagnostic relevance of humoral and cell—mediated immune reactions in patients with acute myocarditis and congestive cardiomyopathy. In: Chazov EL, Smirnov VN, Organov RG (eds) Cardiology. Plenum, London, pp 1327–1338Google Scholar
  152. 151.
    Maisch B (1984) Humorale immunologische Effecktormechanismen bei Perimyokarditis. Internist (Berlin) 25: 155–164Google Scholar
  153. 152.
    Maisch B (1985) Rickettsial perimyocarditis: a follow up study. Heart Vessels 2: 55–59Google Scholar
  154. 153.
    Maisch B (1985) Surface antigens of adult heart cells and their use in diagnosis. Basic Res Cardiol 80 Suppl 1: 47–52Google Scholar
  155. 154.
    Maisch B (1986) Immunologic regulator and effector functions in perimyocarditis, postmyocarditic heart muscle disease and dilated cardiomyopathy. Basic Res Cardiol 81 Suppl 1: 217–242Google Scholar
  156. 155.
    Maisch B (1987) Immunological mechanisms in human cardiac injury. In: Spry JE (ed) Immunology and molecular biology of cardiovascular disease (Current status of clinical cardiology). MTP, London, pp 225–252Google Scholar
  157. 156.
    Maisch B (1987) The sarcolemma as antigen in the secondary immunopathogenesis of myopericarditis. Eur Heart J 8 Suppl J: 155–165Google Scholar
  158. 157.
    Maisch B (1988) The use of myocardial biopsy in heart failure. Eur Heart 9 Suppl H: 59–71Google Scholar
  159. 158.
    Maisch B (1989) Autoreactivity to the cardiac myocyte, connective tissue and the extracellular matrix in heart disease and postcardiac injury. Springer Semin Immunopathol 11: 369–396PubMedGoogle Scholar
  160. 159.
    Maisch B, Drude L (1991) Pericardioscopy: a new diagnostic tool in inflammatory diseases of the pericardium. Eur Heart J 12 Suppl D: 2–6Google Scholar
  161. 160.
    Maisch B, Kochsiek K (1983) Humoral immune reactions in uremic pericarditis. Am J Nephrol 3: 264–271PubMedGoogle Scholar
  162. 161.
    Maisch B, Wendl J (1989) Cytomegalovirus DNA in endomyocardial biopsies of patients with (peri)myocarditis (Abstr). Eur Heart J 9 Suppl 1: 1000Google Scholar
  163. 162.
    Maisch B, Berg PA, Schuff-Werner P, Kochsiek K (1979) Clinical significance of immunopathological findings in patients with postpericardiotomy syndrome. I. Relevance of antibody pattern. Clin Exp Immunol 38: 189–197Google Scholar
  164. 163.
    Maisch B, Berg PA, Schuff-Werner P, Kochsiek K (1979) Clinical significance of immunpathological findings in patients with postpericardiotomy syndrome. II. The significance of serum inhibition and rosette inhibitory factors. Clin Exp Immunol 38: 198–203Google Scholar
  165. 164.
    Maisch B, Berg PA, Kochsiek K (1980) Immunological parameters in patients with congestive cardiomyopathy. Basic Res Cardiol 75: 221–222PubMedGoogle Scholar
  166. 165.
    Maisch B, Trostel-Soeder R, Berg A, Kochsiek K (1981) Assessment of antibody mediated cytolysis of adult cardiocytes isolated by centrifugation in a continuous gradient of Percoll in patients with acute myocarditis. J Immunol Methods 44: 159–169PubMedGoogle Scholar
  167. 166.
    Maisch B, Maisch S, Kochsiek K (1982) Immune reactions in tuberculous and chronic constrictive pericarditis. Am J Cardiol 50: 1007–1013PubMedGoogle Scholar
  168. 167.
    Maisch B, Mayer E, Kochsiek K (1982) Nachweis zirkulierender Immunkomplexe bei kardialen Erkrankungen. Verh Dtsch Ges Inn Med 88: 624–627Google Scholar
  169. 168.
    Maisch B, Trostel-Soeder R, Stechermesser E, Berg PA, Kochsiek K (1982) Diagnostic relevance of humoral and cell-mediated immune reactions in patients with acute viral myocarditis. Clin Exp Immunol 48: 533–545PubMedGoogle Scholar
  170. 169.
    Maisch B, Deeg P, Liebau G, Kochsiek K (1983) Diagnostic relevance of humoral and cytotoxic immune reactions in patients with primary and secondary heart muscle disease. Am J Cardiol 52: 1072–1078PubMedGoogle Scholar
  171. 170.
    Maisch B, Mayer E, Schubert U, Berg PA Kochsiek K (1983) Immune reactions in infective endocarditis. Relevance of circulating immune complexes, of serum inhibition factors, of lymphocytotoxic reactions, and of antibody dependent cellular cytotoxicity against cardiac target cells. Am Heart J 106: 338–344Google Scholar
  172. 171.
    Maisch B, Büschel G, Izumi T, Eigel P, Regitz V, Deeg P, Pfeifer U, Schmaltz A, Herzum M, Kochsiek K (1985) Four years of experience in endomyocardial biopsy: an immunohistologic approach. Heart Vessels Suppl 1: 59–67PubMedGoogle Scholar
  173. 172.
    Maisch B, Lotze U, Schneider J, Kochsiek K (1985) Antibodies to human sinus node in sick sinus syndrome. New Trend Arrhythmias 1: 417–421Google Scholar
  174. 173.
    Maisch B, Lotze U, Schneider J, Kochsiek K (1986) Antibodies to human sinus node in sick sinus syndrome. PACE 9: 1101–1109PubMedGoogle Scholar
  175. 174.
    Maisch B, Bauer E, Thometzek P, Herzum M, Kochsiek K (1987) Autoreactive immune mechanisms in infective endocarditis. Eur Heart J 8 Suppl J: 311–318Google Scholar
  176. 175.
    Maisch B, Cirsi M, Gehrke J, Kirschner A (1987) Lectin binding sites of the sarcolemma and surrounding interstitial tissue. Eur Heart J 8 Suppl 5: 175Google Scholar
  177. 176.
    Maisch B, Dienesch C, Wendl I (1987) Effect of leukotrienes on isolated vital cardiac cells: an in vitro model of cardiocytotoxic mediators in inflammation? Eur Heart J 8 Suppl J: 463–465Google Scholar
  178. 177.
    Maisch B, Hauck H, Königer U, Endter S, Klopf D, Schmier U, Schmier K (1987) Suppressor cell activity in (peri)myocarditis and infective endocarditis. Eur Heart J Suppl 8: 147–153Google Scholar
  179. 178.
    Maisch B, Hufnagel G, Bauer E, Haverich A, Schäfers HJ, Kemnitz J, Borst HG (1987) Value of immunohistological and immunoserological monitoring in cardiac transplantation. Eur Heart J 8 Suppl J: 29–34Google Scholar
  180. 179.
    Maisch B, Schwab D, Bauer E, Sandhage K, Schmaltz AA (1987) Antimyolemmal antibodies in myocarditis in children. Eur Heart J 8 Suppl J: 167–173Google Scholar
  181. 180.
    Maisch B, Selmayer N, Brugger E, Ertl G, Eilles C, Heinrich J, Gerhard W, Hufnagel G, Schmidt M, Kochsiek K (1987) Cardiac sarcoidosis: clinical and immunoserological study. Eur Heart J 8 Suppl J: 63–71Google Scholar
  182. 181.
    Maisch B, Wedeking U, Kochsiek K (1987) Quantitative assessment of antilaminin antibodies in myocarditis and perimyocarditis. Eur Heart J 8: Suppl J 233–235Google Scholar
  183. 182.
    Maisch B, Wittner B, Wiethölter H (1987) Experimental myocarditis in rabbits: cellular effector mechanisms. Eur Heart J 8 Suppl J: 425–432Google Scholar
  184. 183.
    Maisch B, Weyerer O. Hufnagel G, Hengstenberg, Schönian U, Haverich A, Kochsiek K (1989) The vascular endothelium as target of humoral autoreactivity in myocarditis and rejection. Z Kardiol 78: 95–99Google Scholar
  185. 184.
    Maisch B, Crombach C, Schönian U(1991) Cytomegalovirus infection as a cause of viral myocarditis (Abstr) Eur Heart J 12 Suppl: 228 (Al216)Google Scholar
  186. 185.
    Maisch B, Outzen H, Roth D, Hiby A, Herzum M, Hengstenberg C, Hnufagel F, Schönian U, Kochsiek K (1991) Prognostic determinants in conventionally treated myocarditis and perimyocarditis: focus on antimyolemmal antibodies. Eur Heart J 12 Suppl D: 76–80Google Scholar
  187. 185a.
    Maisch B, Schönian U (1992) Assessment of cytomegalovirus-DNA in endomyocardial biopsies of patients with myococarditis. Circulation 86 (Suppl I): 793 Abstr. 3157Google Scholar
  188. 185a.
    Maisch B, Schönian U (1992) Assessment of cytomegalovirus-DNA in endomyocardial biopsies of patients with myococarditis. Circulation 86 (Suppl I): 793 Abstr. 3157Google Scholar
  189. 187.
    Mall G, Klingel K, Albrecht M, Seemann M, Rieger P, Kandolf R (1991) Natural history of coxsackievirus B3-induced myocarditis in ACA/Sn mice: viral persistence demonstrated by quantitative in situ hybridization histochemistry. Eur Heart J 12 Suppl D: 121, 123Google Scholar
  190. 188.
    Mason JW, Billingham ME, Ricci DR (1980) Treatment of acute inflammatory myocarditis assisted by endomyocardial biopsy. Am J Cardiol 45: 1037–1044PubMedGoogle Scholar
  191. 189.
    Maut K (1963) Mort subité due à une myocardité focale suivant une vaccination contre la variole. Ann Med Leg 43: 1–3Google Scholar
  192. 190.
    McManus BM, Galinit CJ, Cassung RS (1988) Immunopathologic basis of myocardial injury. Cardiovasc Clin 18: 163–184PubMedGoogle Scholar
  193. 191.
    Mills AS, Hastillo A, Hess ML (1984) Lymphocytic infection of he myocardium in idiopathic dilated cardiomyopathy: underestimation of myocarditis with endomyocardial biopsy (Abstr). Circulation 70 Suppl 2: 401Google Scholar
  194. 192.
    Monif GRG, Lee CW, Hsiung GD (1967) Isolated myocarditis with recovery of ECHO type 9 virus from the myocardium. N Engl J Med 277: 1353–1355PubMedGoogle Scholar
  195. 193.
    Moore CM, Henry J, Benzing G, Kaplan S (1969) Varicella myocarditis. Am J Dis Child 118: 899–902PubMedGoogle Scholar
  196. 194.
    Mues B, Brisse B, Zwaldo G, Ghemann H, Bender F, Sorg C (1989) Myocarditis diagnosis: use of monoclonal antibodies to macrophages in immunocytology. 7th International Congress of Immunology, July 30—Aug 8, BerlinGoogle Scholar
  197. 195.
    Neu N, Beisel K, Traystman M, Rose N, Craig SW (1987) Autoantibodies specific for the cardiac myosin isoform are found in mice susceptible to coxsackie virus B3-induced myocarditis. J Immunol 138: 2488PubMedGoogle Scholar
  198. 196.
    Neu N, Rose NR, Beisel KW, Herskowitz A, Gurri-Glass G, Craig SW (1987) Cardiac myosin induces myocarditis in genetically presdisposed mices. J Immunol 138: 2488–2492PubMedGoogle Scholar
  199. 197.
    Obermayer U, Scheidler J, Maisch B (1987) Antibodies against micro-and intermediate filaments in carditis and dilated cardiomyopathy: are they a diagnostic marker? Eur Heart J 8: Suppl J, 181–186Google Scholar
  200. 198.
    Obiassi M, Brucato A, Meroni PL, Vismara A, Lettin M, Poloni F, Finzi A, Fenini MG, Rossi L (1987) Antibodies to cardiac Purkinje cells: further characterization in autoimmune disease and atrioventricular heart block. Clin exp Immunol 42: 141–148Google Scholar
  201. 199.
    Oceasohn R, Adelson L, Kaji M (1959) Clinicopathologic study of thirty-three fatal cases of Asian influenza. N Engl J Med 260: 509–518Google Scholar
  202. 200.
    Osborn M (1984) Summary: intermediate filaments. Ann NY Acad Sci 455: 669Google Scholar
  203. 201.
    Parillo JE, Cunnion RE, Ebstein SE, Parker MM, Suffredini AV, Brenner M, Saer GL, Palmeri ST, Cannon RO, Ailing D, Wittes JT, Ferrans VJ, Roderigues ER, Fauci AS (1989) A prospective, randomized, controlled trial of prednisone for dilated cardiomyopathy. N Engl J Med 321: 1061–1068Google Scholar
  204. 202.
    Paris S, Fosset M, Samuel D, Ailhaud G (1977) Chick embryo plasma membrane from cardiac muscle and cultured heart cells: isolation procedures and absence of fatty acid-activation enzymes. J Mol Cell Cardiol 9: 161–173PubMedGoogle Scholar
  205. 203.
    Perimann P, Perlmann H (1971) Cytotoxic lymphocytes: mechanisms of activation and target cell destruction. Int Arch Allergy 41: 36–39Google Scholar
  206. 204.
    Pollard TD (1976) Cytoskeletal function of cytoplasmic contracile protein. J Supramol Struct 5: 317–327PubMedGoogle Scholar
  207. 205.
    Ragosta M, Crabtree J, Sturner WQ, Thompson PD (1980) Report of the WHO/ISFC Task Force on the definition and classification of cardiomyopathies. Br Heart J 44: 672Google Scholar
  208. 206.
    Rose ML, Coles MI, Griffin RJ, Pomerance A, Yacoub MH (1986) Expression of class I and class II major histocompatibility antigens in normal and transplanted human heart. Transplantation 41: 776–782PubMedGoogle Scholar
  209. 207.
    Rose NR, Wolfgram U, Herskowitz A, Beisel KW (1986) Postinfectious autoimmunity: two distinct phases of coxsackievirus B3-induced myocarditis. Ann NY Acad Sci 475: 146–156PubMedGoogle Scholar
  210. 207a.
    Ross E, Armentrout SA (1962) Myocarditis associated with rabies: Report of a case. N Engl J Med 260: 1087–1089Google Scholar
  211. 208.
    Sack W, Scheurin H, Wachsmut ED (1975) Antikörper gegen Herzmuskelsarkolemm im Serum von Patienten mit primärer Cardiomyopathie. Klin Wochenschr 53: 103–111PubMedGoogle Scholar
  212. 209.
    Sainani GS, Krompotic E, Slodki SJ (1968) Adult heart disease due to the Coxsackie virus B infection. Medicine (Baltimore) 47: 133–147Google Scholar
  213. 210.
    Sampson CC (1959) Varicella myocarditis: report of case. J Natl Med Assoc 51: 138–139PubMedGoogle Scholar
  214. 211.
    Samsonov M, Nassonov E, Kostin S, Samko A, Alexandrova L, Masenko V, Naumov V, Mareev V, Shevlyagin S, Zhadanov V (1991) Serum neopterin: possible immunological marker of myocardial inflammation in patients with dilated heart muscle disease. Eur Heart J 12 Suppl D: 147–150Google Scholar
  215. 212.
    Samuel JL, Rappaport K, Mercadie JJ, Lompre AM, Sartore S, Triban C, Schiaffina S, Schwartz K (1983) Distribution of myosin isozymes with single cardiac cells. Cire Res 52: 200–209Google Scholar
  216. 213.
    Samuel JL, Schwartz K, Lompre AM, Delcayre C, Marotte F, Swynghedauw B, Rapparot L (1983) Immunological quantitation and localizatiom of tubulin in adult rat heart isolated myocytes. Eur J Cell Biol 31: 99–103PubMedGoogle Scholar
  217. 214.
    Saphir O, Amromin GD, Yokoo H (1956) Myocarditis in viral (epidemic) hepatitis. Am J Med Sci 231: 168–176PubMedGoogle Scholar
  218. 215.
    Schaper J, Froede R, Bleese N, Lüthe N, Schaper W (1987) Veränderungen der Ultrastruktur und des Zytoskeletts in explantierten menschlichen Herzen. Z Kardiol 77 Suppl 1: 82Google Scholar
  219. 216.
    Schaper J, Froede, Buck A, Bleese N (1989) Impaired myocardial ultra-structure and cytoskeleton in cardiomyopathic human myocardium. In: Schultheiss H-P (ed) New concepts in viral heart disease. Springer, Berlin Heidelberg New York, pp 295–302Google Scholar
  220. 217.
    Schönian U, Maisch B (1989) Cellular ELISA for antimyolemmal antibodies (A MLA) in DCM and myocarditis (Abstr). 7th International Congress of Immunology, July 30–Aug 8, BerlinGoogle Scholar
  221. 218.
    Schönian U, Crombach M, Maisch B (1991) Does CMV infection play a role in myocarditis? New aspects form in-situ hybridization. Eur Heart J 12 Supf D: 65–68Google Scholar
  222. 219.
    Schramm P (1986) Rarissima, I, TAUNUS-VERLAG 4Google Scholar
  223. 220.
    Schultheiss HP (1987) The mitochrondrium as antigen in inflammatory heart disease. Eur Heart J 8 Suppl J: 203–210Google Scholar
  224. 221.
    Schultheiss HP (1989) the significance of autoantibodies against the ADP/ATP carrier for the pathogenesis of myocarditis and dilated cardiomyopathy: clinical and experimental data. Springer Semin Immunopathol 11: 15–30Google Scholar
  225. 222.
    Schultheiss HP, Botte HD (1985) Immunological analysis of autoantibodies against the adenine nucleotide translocator in dilated cardiomyopathy. J Mol Cell Cardiol 17: 603–617PubMedGoogle Scholar
  226. 223.
    Schultheiss HP, Kühl U (1987) Charakterisierung verschiedener Autoantikörper gegen myokardiale Matrixproteine by Myokarditis und dilativer Kardiomyopathie. Klin Wochenschr 65: Suppl 9: 263Google Scholar
  227. 224.
    Schultheiss HP, Bolte HD, Schwimmbeck P (1984) Autoantibodies against the adenine nucleotide translocator in myocarditis and dilated cardiomyopathy. In: Botte HD (ed) Viral heart disease. Springer, Berlin Heidelberg New York, pp 131–143Google Scholar
  228. 225.
    Schulze K, Becker BF, Strauer B, Schultheiss HP (1990) Antibodies to ADP/ATP carrier— an autoantigen in myocarditis and dilated cardiomyopathy—impair cardiac function. Circulation 81: 959–969PubMedGoogle Scholar
  229. 226.
    Schwartz P, Piper HM, Spahr R, Hütter JF, Spiekermann PF (1985) Development of new intercellular contracts between adult cardiac myocytes in culture. Basic Res Cardiol 80 Suppl 1: 75–79Google Scholar
  230. 227.
    Schwarz RS (1986) Are natural autoantibodies real? Ann Immunol (Paris) 137: 156–158Google Scholar
  231. 228.
    Schwimmbeck PL, Schultheiss HP, Strauer BE (1989) Identification ofa main autoimmunogenic epitope of the adenine nucleotide translocator which cross-reacts with coxsackie B3 virus: use in the diagnosis of myocarditis and dilatative cardiomyopathy (Abstr), Circulation 80 Suppl 2: 2642Google Scholar
  232. 229.
    Segusa J, Prabhakar BS, Essani K, McClintock PR, Fukuda Y, Ferrans VJ, Notkins AL (1986) Monoclonal antibody to coxsackievirus B4 reacts with myocardium. J Infect Dis 153: 372–373Google Scholar
  233. 230.
    Seligman M (1986) The origin and nature of autoantibodies: introduction. Ann Immunol (Paris) 137: 149–150Google Scholar
  234. 231.
    Senécal J-L, Fortin S, Roussin A, Joyal F (1987) Anticytoskeletal autoantibody to microfila- ment anchorage sites recognizes novel focal contact proteins. J Clin Invest 80: 778–785PubMedGoogle Scholar
  235. 232.
    Shanes Gahli J, Billingham ME, Ferrans VJ, Fenoglio JJ, Edwards WD, Tsai CC, Saffitz JE, Isner J, Futter S, Subramanian R (1987) Interobserver variability in the pathologic interpretation of endomyocardial biopsy results. Circulation 75: 401–405Google Scholar
  236. 233.
    Sylvest E (1934) Epidemic myalgia: Bornholm disease. London, OxfordGoogle Scholar
  237. 234.
    Szarman A, Terranova VP, Rennard SI, Fiodart J-M, de Datima Lima M, Scheinman JI, Martin GR (1982) Antibodies to laminin in Chagas’ disease. JE p Med 155: 1161–1169Google Scholar
  238. 235.
    Tatter D, Gerad PW, Silverman AH, Wang C, Peterson HE (1964) Fatal varicella pancarditis in a child. Am J Dis Child 108: 88–93PubMedGoogle Scholar
  239. 236.
    Tazzari PI, Gobbi M, Zauli D, Tassinari A, Crespi C, Miserocchi F, Dinota A, Bandini G, Ricci P, Ura S (1987) Close association between antibodies to cytoskeletal intermediate filaments and chronic graft-versus-host disease. Transplantation 44: 234–237PubMedGoogle Scholar
  240. 236a.
    Thiede WH (1962) Cardiac involvement in lymphocytic choriomeningitis Arch Intern Med 109: 50–54Google Scholar
  241. 237.
    Thometzek P, Maisch B (1987) Antibodies cross-reactive to streptococci in infective endocarditis. Eur Heart J 8 Suppl J: 318–321Google Scholar
  242. 238.
    Timpl R (1979) Lamini: a glycorprotien from basement membranes. J Biol Chem 254: 99339937Google Scholar
  243. 239.
    Van Houten N, Huber SA (1989) Role of cytoxic T-cells in experimental myocarditis. Springer Semin Immunopathol 11: 61–68PubMedGoogle Scholar
  244. 240.
    Von Schroetter P (1899) Die Insuffizienz des Herzmuskels. Verh Congr Inn Med, 50: 17–23Google Scholar
  245. 241.
    Wallukat G, Boewer V (1988) Stimulation of chronotropic beta-adrenoceptors of cultured neonatal rat heart myocytes by the serum of gammaglobulin fraction of patients with dilated cardiomyopathy and myocarditis. In: Internationales Symposium: Herzinsuffizienz, Pathogenese and Differentialtherapie, Feb 28—March 2 Berlin. Universitätsverlag, Berlin (Book of Abstracts, A 24 )Google Scholar
  246. 242.
    Waterson AP (1978) Virology investigation in congestive cardiomyopthy. Postgrad Med J 54: 505–509PubMedGoogle Scholar
  247. 243.
    Weber KT, Janicki JS, Pick R, Abrahams C, Shroff SG, Bashey RI, Chen RM (1987) Collagen in hypertrophied, pressure-overloaded myocardium. Circulation 75 Suppl 1: 1–9Google Scholar
  248. 244.
    Weiland DS, Donaldson KP, Isner JM (1984) How well does the endomyocardial biopsy represent the state of the heart? (Abstr) Circulation 70 Suppl 2: 501Google Scholar
  249. 245.
    Weinstein L, Shelokov A (1951) Cardiovascular manifestations in acute poliomyelitis. N Engl J Med 244: 281–285PubMedGoogle Scholar
  250. 246.
    Weiss MB, Ursell PC, Scala F, Frusin R, Genoglio JJ Jr (1982) Immunosuppression therapy in chronic forms of myocarditis (Abstr). Circulation 66 Suppl 2: 215Google Scholar
  251. 247.
    Wittner B, Maisch B, Kochsiek K (1983) Quantification of antimyosin antibodies in experimental myocarditis by a new solid-phase fluorometric assay. J Immunol Methods 64: 239–247PubMedGoogle Scholar
  252. 248.
    Wolfgram LJ, Beisel KW, Rose NR (1985) Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis. J Exp Med 161: 1112–1121PubMedGoogle Scholar
  253. 249.
    Wolfgram LJ, Beisel KW, Herskowitz A, Rose NR (1986) Variations in the susceptibilty to coxsackievirus B3-induced myocarditis among different strains of mice. J Immunol 136: 18461852Google Scholar
  254. 250.
    Wong Y, Woodruff JJ, Woodruff JF (1977) Generation of cytolytic T-lymphocytes during Coxsackie virus B3 infection. I. Model and viral specificity. J Immunol 118: 1159–1164Google Scholar
  255. 251.
    Wong Y, Woodruff JJ, Woodruff JF (1977) Generation of cytolytic T-lymphocytes during Coxsackie virus B3 infections. II. Characterization of effector cells, and demonstration of cytotoxicity against viral infected myofibers. J Immunol 118: 1165–1169Google Scholar
  256. 252.
    Woodruff JF (1980) Viral myocarditis: a review article. Am J Pathol 101: 425–484PubMedGoogle Scholar
  257. 253.
    Yamada K, Akiyama S, Hasegawa T, Gasegawâ E, Humphries M, Kennedy D, Nagata K, Urishihara H, Olden K, Chen W (1985) Recent advances in the research on fibronectin and other cell attachment proteins. J Cell Biochem 28Google Scholar
  258. 254.
    Yamakawa K, Fukuta S, Yoshinaga T, Umenoto S, Itagaki T, Kusukawa R (1987) Study of immunological mechanism in dilated cardiomyopathy. Jpn Circ J 51: 665–675PubMedGoogle Scholar
  259. 255.
    Yu Z, Sekiguchi M, Niroe M, Take M, Hirosawa K (1984) Histopathological findings of acute and convalescent myocarditis obtained by serial biopsy. Jpn Circ J 48: 1368–1371PubMedGoogle Scholar
  260. 256.
    Zinkemagel RM, Doherty PC (1974) Restriction of the in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature 248: 701–702Google Scholar

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© Springer-Verlag Berlin Heidelberg 1993

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  • B. Maisch
  • M. Herzum

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