Familial Adenomatous Polyposis: Current Status in Switzerland

  • Rodney J. Scott
  • Martina Spycher
  • Walter Weber
  • Hansjakob Müller
Conference paper
Part of the ESO Monographs book series (ESO MONOGRAPHS)

Abstract

The incidence of Familial Adenomatous Polyposis (FAP) has been shown to be somewhere between 1 in 10,000 and 1 in 20,000 people (taken from the Danish Polyposis Registry). Familial Adenomatous Polyposis is an autosomal dominantly inherited disease characterised by the appearance in the colon of hundreds to thousands of adenomatous polyps at an early age. If left untreated, the disease progresses from the adenomatous stage to adenocarcinoma in virtually 100% of cases. Integrally associated with FAP is a very much severe form of the disease, Gardner’s syndrome, which is characterised by desmoid tumors and osteomas.

Keywords

Adenocarcinoma Recombination Adenoma Electrophoresis Hepatoblastoma 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Rodney J. Scott
    • 1
  • Martina Spycher
    • 1
  • Walter Weber
    • 1
  • Hansjakob Müller
    • 1
  1. 1.Institute of Human Genetics, Research DepartmentKantonsspital BaselSwitzerland

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