Desmoids in Gardner’s Syndrome: A Challenge for Surgeons

  • S. Martinoli
  • L. Mariani
  • A. Goldhirsch
Conference paper
Part of the ESO Monographs book series (ESO MONOGRAPHS)


Gardner’s first description [1] of the association of familial adenomatous polyposis (FAP) with osteomas and skin lesions (1951–1953) was followed by steadily increasing discoveries of other extracolonic manifestations, such as upper gastrointestinal lesions (fundic gland polyps, true gastric and duodenal adenomas) [2], desmoid tumours, retinal changes and other more unusual associations like brain tumours [3], papillary carcinoma in the thyroid [4] and hepatoblastomas [5].


Familial Adenomatous Polyposis Brachial Plexus Papillary Carcinoma Desmoid Tumor Familial Polyposis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Gardner EJ and Richards RC: Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary intestinal polyposis and esteomas. Am J Hum Genet 1953 (5):139–147PubMedGoogle Scholar
  2. 2.
    Watanabe H, Enjoji M, Yao T and Oshato K: Gastric lesions in familial adenomatosis coli: their incidence and histological analysis. Human Pathology 1978 (9):269–283PubMedCrossRefGoogle Scholar
  3. 3.
    Turcot J, Despres JP and St. Pierre F: Malignant tumors of the central nervous system associated with familial polyposis of the colon. Dis Colon Rectum 1959(2):465PubMedCrossRefGoogle Scholar
  4. 4.
    Plail RO, Glazer G, Thomson JPS and Bussey HJR: Adenomatous polyposis: an association with carcinoma of the thyroid? Br J Surg 1985 (72): 1385Google Scholar
  5. 5.
    Garber GE, Li FP and Kingston JE: Hepatoblastoma and familial adenomatous polyposis. JNCI 1988 (80):1626–1628PubMedGoogle Scholar
  6. 6.
    Bussey HJR, Evers AA, Ritchie SM and Thompson JPS: The rectum in adenomatous polyposis: the St. Mark’s policy. Br J Surg 1985 (72):529–531CrossRefGoogle Scholar
  7. 7.
    Reitamo JJ, Scheinin TM and Häyry P: The desmoid syndrome: new aspects in the cause, pathogenesis and treatment of the desmoid tumor. Am J Surg 1986 (151):230–237PubMedCrossRefGoogle Scholar
  8. 8.
    Stevenson JK: Unfamiliar aspects of familial polyposis coli. Am J Surg 1986 (152):81–86PubMedCrossRefGoogle Scholar
  9. 9.
    Eagel BA, Zentler-Munro and Smith JE: Mesenteric desmoid tumors in Gardner’s syndrome -Review of medical treatments. Postgrad Med J 1989 (65):497–501PubMedCrossRefGoogle Scholar
  10. 10.
    Waddell WR: Treatment of intraabdominal and abdominal wall desmoid tumors with drugs that affect the metabolism of cyclic 3’5’adenosin monophosphate. Ann Surg 1975 (81):299CrossRefGoogle Scholar
  11. 11.
    Wilson AJ, Baum M, Singh L and Kangas L: Antioestrogen therapy of pure mesenchymal tumour. Lancet 1987 (i):508CrossRefGoogle Scholar
  12. 12.
    Bussey HJR: Familial Polyposis Coli: Family Studies, Histopathology, Differential Diagnosis and Results of Treatment. Baltimore: Johns Hopkins University Press 1975Google Scholar
  13. 13.
    Lotfi AM, Dozois RR, Gordon H et al: Mesenteric fibromatosis complicating familial adenomatous polyposis: predisposing factors and result of treatment. Int J Colorect Dis 1989 (4):30–36CrossRefGoogle Scholar
  14. 14.
    Jones IT, Fazio VW and Weakly FL: Desmoid tumors in familial polyposis coli. Ann Surg 1986 (204):94–97PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • S. Martinoli
    • 1
  • L. Mariani
    • 1
  • A. Goldhirsch
    • 1
  1. 1.Department of Surgery and Division of OncologyOspedale CivicoLuganoSwitzerland

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