Accelerated Degradation Test on Resorbable Polymers

  • Berthold Buchholz


Polyesters derived from aliphatic hydroxy carbonic acids are a well known class of synthetic bioresorbable polymers. The biodegradation normally proceeds by random bulk hydrolysis of ester bonds without a significant contribution of enzymatic attack. Enzymatic surface erosion is restricted to rubbery polylactones with low elastic moduli with only one example reported in the literature 2. As rubbery polylactones, rubbery poly(ethylene carbonate) 3 and poly(trimethylene carbonate) 4 are reported to degrade in vivo by enzymatic action.


Hydrolysis Rate Ethylene Carbonate Hydrolysis Time Inherent Viscosity Semilog Plot 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Berthold Buchholz
    • 1
  1. 1.Boehringer Ingelheim KGA Entwicklung ChemikalienIngelheimGermany

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