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Accelerated Degradation Test on Resorbable Polymers

  • Berthold Buchholz

Abstract

Polyesters derived from aliphatic hydroxy carbonic acids are a well known class of synthetic bioresorbable polymers. The biodegradation normally proceeds by random bulk hydrolysis of ester bonds without a significant contribution of enzymatic attack. Enzymatic surface erosion is restricted to rubbery polylactones with low elastic moduli with only one example reported in the literature 2. As rubbery polylactones, rubbery poly(ethylene carbonate) 3 and poly(trimethylene carbonate) 4 are reported to degrade in vivo by enzymatic action.

Keywords

Hydrolysis Rate Ethylene Carbonate Hydrolysis Time Inherent Viscosity Semilog Plot 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Berthold Buchholz
    • 1
  1. 1.Boehringer Ingelheim KGA Entwicklung ChemikalienIngelheimGermany

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