Testing of Pur-Biomaterials for Enzymaticauy Induced Degradation: An in Vitro Study
The enzymatically induced degradation of a group of medical grade polyurethanes (PUR) for cardiovascular applications such as heart valve prostheses and blood pumps has been investigated. Mechanical stability of these polyether-, polyester- and polyurethaneureas has been tested by incubation of microtensile specimens according to ASTM 1708–79 into enzymatic solutions and bovine blood plasma for up to 4 months. The degree of degradation is assessed by measuring tensile properties, water absorption and molecular weight. Changes in surface quality are determined by SEM and contact angle measurements. The results so far reveal degradative changes depending on PUR-type and type of enzyme but to a degree not impairing the implant function within the chosen test period and test conditions.
KeywordsFatigue Hydrolysis Urea Ethylene Glycol Polypeptide
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- 1.Anderson JM (1984) In: Planck H et al. (eds) Polyurethanes in Biomedical Engineering. Elsevier, Amsterdam, 143Google Scholar
- 2.Glasmacher-Seiler B (1991) in pressGoogle Scholar
- 3.Glasmacher-Seiler B, Erens B, Doersch M, Reul H, Rau G, Wiek G, Pietsch H (1990) In: Heimke G et al. (eds) Clinical Implant Materials. Elsevier, Amsterdam, 105Google Scholar
- 4.Hiltner A, Anderson JA (1983) Dev. & Techn. B. Contr. Meeting NIHGoogle Scholar
- 5.Lemm W, Pirling L, Bücherl ES (1980) Trans. ESAO: 86Google Scholar
- 9.Ratner BD, Gladhill KW, Horbett TA (1986) Trans. 12th Annual Meeting of the Society for Biomaterials: 190Google Scholar
- 11.Williams DF (1977) J Bioengineering 1: 279–294Google Scholar