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Motivational Effects of Opioids

  • Chapter
Opioids II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 104 / 2))

Abstract

A prominent behavioral effect of opiates and other drugs of abuse is their ability to affect both mood and motivational processes. μ-Receptor agonists such as morphine or heroin produce euphoria in humans and function as positive reinforcers in a variety of species, i.e., they maintain those behaviors which lead to their administration. These agents are also characterized by their ability to function as conditioned reinforcers eliciting approach and subsequent preferences for stimuli previously associated with their administration. Furthermore, in some individuals, the reinforcing effects of these drugs may become so marked that they become the primary stimuli which motivate behavior, and the process of compulsive drug-seeking or addiction ensues.

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Authors
  1. T. S. Shippenberg
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Editors and Affiliations

  1. Abteilung Neuropharmakologie, Max-Planck-Institut für Psychiatrie, Am Klopferspitz 18, W-8033, Martinsried, Germany

    Albert Herz

  2. Mental Health Research Institute, School of Medicine, University of Michigan, 205 Zina Pitcher, 48109, Ann Arbor, MI, USA

    Huda Akil

  3. Medical Center, School of Medicine, New York University, 550 First Avenue, 10016, New York, NY, USA

    Eric J. Simon

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Shippenberg, T.S. (1993). Motivational Effects of Opioids. In: Herz, A., Akil, H., Simon, E.J. (eds) Opioids II. Handbook of Experimental Pharmacology, vol 104 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77540-6_26

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  • DOI: https://doi.org/10.1007/978-3-642-77540-6_26

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