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Opioids II pp 573-596 | Cite as

Opioid Tolerance and Physical Dependence and Their Relationship

  • E. L. Way
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 104 / 2)

Abstract

Two well-known consequences of frequent and repeated administration of opioids are tolerance and physical dependence. Tolerance is demonstrable by a gradual loss of effectiveness of an agonist after repeated administration, and proportionately higher doses of the compound become necessary to elicit the same response. In the tolerant state, physical dependence also can usually be demonstrated, as evidenced by the need to continue administering the compound to avoid physical discomfort. Its discontinuance results in a constellation of signs and symptoms that are generally opposite to those observed after acute administration and are immediately reversible by readministration of the agonist.

Keywords

Adenylate Cyclase Physical Dependence Opiate Receptor Locus Ceruleus Chronic Morphine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1993

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  • E. L. Way

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