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Opioids in the Neurohypophysial System

  • Chapter
Opioids II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 104 / 2))

  • 269 Accesses

Abstract

The reported effects of morphine on antidiuresis in the rat provided the first indication that the secretions of the neurohypophysial system could be regulated by opioids (De Bodo 1944). Amongst the neuroendocrine systems it is in the neurohypophysial system that the actions of opioids and the physiological functions of the endogenous peptides are now best understood. Opioid peptides are intrinsic to the neurohypophysial system. This was first suggested by the extraction of leu-enkephalin from the combined neural and intermediate lobes of the rat pituitary (Rossier et al. 1977). Confirmation of a hypothalamic enkephalin pathway terminating specifically in the neural lobe was obtained using immunocytochemistry and extraction of leu-enkephalin from this isolated tissue (Rossier et al. 1977, 1980). Proopiomelanocortin (POMC)-derived β-endorphin was found to be confined to intermediate and anterior pituitary lobes (Bloom et al. 1977). Extraction of dynorphin peptides from neurointermediate pituitary was reported around this time (Goldstein and Ghazarossian 1980), as was the presence of dynorphin immunoreactive fibres confined to the neural lobe (Watson et al. 1981).

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Authors
  1. R. J. Bicknell
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Editors and Affiliations

  1. Abteilung Neuropharmakologie, Max-Planck-Institut für Psychiatrie, Am Klopferspitz 18, W-8033, Martinsried, Germany

    Albert Herz

  2. Mental Health Research Institute, School of Medicine, University of Michigan, 205 Zina Pitcher, 48109, Ann Arbor, MI, USA

    Huda Akil

  3. Medical Center, School of Medicine, New York University, 550 First Avenue, 10016, New York, NY, USA

    Eric J. Simon

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© 1993 Springer-Verlag Berlin Heidelberg

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Bicknell, R.J. (1993). Opioids in the Neurohypophysial System. In: Herz, A., Akil, H., Simon, E.J. (eds) Opioids II. Handbook of Experimental Pharmacology, vol 104 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77540-6_21

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  • DOI: https://doi.org/10.1007/978-3-642-77540-6_21

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