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Opioid Mechanisms in the Control of Food Consumption and Taste Preferences

  • Chapter
Opioids II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 104 / 2))

Abstract

HOLTZMAN (1974, 1975) was the first to report that the pure opioid receptor antagonist, naloxone, significantly reduced food consumption in rats. At first these unexpected results were difficult to interpret. However, following the discovery of endogenous opioid peptides, these data could be explained in terms of the antagonism of endogenous opioid activity (SANGER 1981; MORLEY and LEVINE 1982; COOPER and SANGER 1984). The suppressant effects of naloxone and other opioid receptor antagonists on feeding behaviour were described initially using food-deprived rats and mice (e.g. HOLTZMAN 1974; ROGERS et al. 1978; MARGULES et al. 1978; BRANDS et al. 1979; BROWN and HOLTZMAN 1979). Naloxone also reduced free-feeding and drinking in rats (COOPER 1980), as well as eating induced by tail pinch (Lowy et al. 1980; MORLEY and LEVINE 1980), by 2-deoxY-D-glucose (SEWELL and JAWAHARLAL 1980), and by electrical stimulation of the brain (CARR and SIMON 1983).

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Authors
  1. S. J. Cooper
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  2. T. C. Kirkham
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Editor information

Editors and Affiliations

  1. Abteilung Neuropharmakologie, Max-Planck-Institut für Psychiatrie, Am Klopferspitz 18, W-8033, Martinsried, Germany

    Albert Herz

  2. Mental Health Research Institute, School of Medicine, University of Michigan, 205 Zina Pitcher, 48109, Ann Arbor, MI, USA

    Huda Akil

  3. Medical Center, School of Medicine, New York University, 550 First Avenue, 10016, New York, NY, USA

    Eric J. Simon

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© 1993 Springer-Verlag Berlin Heidelberg

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Cooper, S.J., Kirkham, T.C. (1993). Opioid Mechanisms in the Control of Food Consumption and Taste Preferences. In: Herz, A., Akil, H., Simon, E.J. (eds) Opioids II. Handbook of Experimental Pharmacology, vol 104 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77540-6_10

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  • DOI: https://doi.org/10.1007/978-3-642-77540-6_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77542-0

  • Online ISBN: 978-3-642-77540-6

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