Skip to main content
SpringerLink
Log in

Tumor Localization by Immunoscintigraphy: Potential and Limitations

  • Conference paper
Book cover Molecular Diagnostics of Cancer

  • 53 Accesses

Abstract

It is worth remembering that positive tumor localization with labeled antibodies was one of the founder technologies of nuclear medicine (for review see [1]). However, the enthusiastic approaches in the 1950s were abandoned when it became clear that the target structures detected by the then available polyclonal antitumor antisera were not actually tumor-specific at all, but, for example, directed against ectopic normal components such as peritumoral fibrin [2–4]

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Pressman D (1980) The development and use of radiolabeled antitumor antibodies. Cancer Res 40:2960–2964

    PubMed  CAS  Google Scholar 

  2. Dewey WC, Bale WF, Rose RG, Marrack D (1963) Localization of antifibrin antibodies in human tumors. Acta Un Int Cancer 19:187–196

    Google Scholar 

  3. Spar IL, Bale WF, Marrack D, Dewey WC, McCardle RJ, Harper PV (1967) 1311-labeled antibodies to human fibrin. Cancer 20:865–870

    Google Scholar 

  4. Bale WF, Contreras MA, Grady ED (1980) Factors influencing localization of labeled antibodies to tumors. Cancer Res 40:2965–2972

    PubMed  CAS  Google Scholar 

  5. Gold P, Freedman SO (1965) Specific carcinoembryonic antigens of the human digestive system. J Exp Med 122:467–481

    Article  PubMed  CAS  Google Scholar 

  6. Gold P, Shuster J (1980) Historical development and potential uses of tumor antigens as markers of human cancer growth. Cancer Res 40:2973–2976

    PubMed  CAS  Google Scholar 

  7. Ruoslahti E, Seppala M (1971) Studies of carcinofetal protein: III. Demonstration of alpha-fetoprotein in serum of healthy adults. Int J Cancer 8:374–379

    Article  PubMed  CAS  Google Scholar 

  8. Kim EE, Deland FH, Nelson MO, Bennett S, Simmons G, Alpert E, Goldenberg DM (1980) Radioimmunodetection of cancer with radiolabeled antibodies to alpha-fetoprotein. Cancer Res 40:3008–3012

    PubMed  CAS  Google Scholar 

  9. Mach J-P, Carrel S, Merenda C (1974) In vivo localization of radiolabeled antibodies to carcinoembryonic antigen in human colon carcinoma grafted into nude mice. Nature 248:704–706

    Article  PubMed  CAS  Google Scholar 

  10. Goldenberg DM, DeLand F, Kim E, Bennett S, Primus FJ, van Nagell JR, Estes N, DeSimone P, Rayburn P (1978) Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning. N Engl J Med 298:1384–1388

    Article  PubMed  CAS  Google Scholar 

  11. Mach J-P, Buchegger F, Forni M, Ritschard J, Berche C, Lumbroso J-D, Schreyer M, Girardet C, Accolla RS, Carrel S (1981) Use of radiolabeled monoclonal anti-CEA antibodies for the detection of human carcinomas by external photoscanning and tomoscintigraphy. Immunol Today 2:239–249

    Article  Google Scholar 

  12. Hnatowich DJ, Childs RL, Lanteigne D, Najafi A (1983) The preparation of DTPA-coupled antibodies radiolabeled with metallic radionuclides: an improved method. J Immunol Methods 65:147–157

    Article  PubMed  CAS  Google Scholar 

  13. Meares CF, McCall MJ, Reardan DT, Goodwin DA, Diamanti CI, McTigue M (1984) Conjugation of antibodies with Afunctional chelating agents: isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal ions. Anal Biochem 142:68–78

    Article  PubMed  CAS  Google Scholar 

  14. Mather SJ, Ellison D (1990) Reduction-mediated technetium-99m labeling of monoclonal antibodies. J Nucl Med 31:692–697

    PubMed  CAS  Google Scholar 

  15. Fritzberg AR (1987) Advances in the 99mTc-labeling of antibodies. Nucl Med 26:7–12

    CAS  Google Scholar 

  16. Wilson CB, Snook DE, Dhokia B, Taylor CVJ, Watson IA, Lammertsma AA, Lambrecht R, Waxman J, Jones T, Epenetos AA (1991) Quantitative measurement of monoclonal antibody distribution and blood flow using positron emission tomography and 124iodine in patients with breast cancer. Int J Cancer 47:344–347

    Article  PubMed  CAS  Google Scholar 

  17. Crowther ME, Britton KE, Granowska M, Shepherd JH (1989) Monoclonal antibodies and their usefulness in epithelial ovarian cancer. Br J Obstet Gynaecol 96:516–521

    Article  PubMed  CAS  Google Scholar 

  18. Baum RP, Lorenz M, Senekowitsch R, Chatal JF, Saccavini JC, Hottenrott C, et al. (1988) Clinical experience in cancer diagnosis with radiolabeled monoclonal antibodies in 200 patients and initial attempts at radioimmunotherapy. In: Srivastava SC (ed) Radiolabeled monoclonal antibodies for imaging and therapy. Plenum, New York, pp 613–651

    Google Scholar 

  19. Wagner HN Jr (1991) Molecular medicine: from science to service. J Nucl Med 32:11N-23N

    PubMed  Google Scholar 

  20. Sun LK, Curtis P, Rakowicz-Szulczynska E, Ghrayeb J, Chang N, Morrison SL, Koprowski H (1987) Chimeric antibody with human constant regions and mouse variable regions directed against carcinoma-associated antigen 17–1 A. Proc Natl Acad Sci USA 84:214–218

    Article  PubMed  CAS  Google Scholar 

  21. Riechmann L, Clark M, Waldmann H, Winter G (1988) Reshaping human antibodies for therapy. Nature 332:323–327

    Article  PubMed  CAS  Google Scholar 

  22. Hale G, Dyer MJ, Clark MR, Phillips JM, Marcus R, Riechmann L, Winter G, Waldmann H (1988) Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1H. Lancet 2:1394–1399

    Article  PubMed  CAS  Google Scholar 

  23. Meredith RF, LoBuglio AF, Plott WE, Orr RA, Brezovich IA, Russell CD, Harvey EB, Yester MV, Wagner AJ, Spencer SA, Wheeler RH, Saleh MN, Rogers KJ, Polansky A, Salter MM, Khazaeli MB (1991) Pharmacokinetics, immune response, and biodistribution of iodine-131-labeled chimeric mouse/ human IgGl,k 17–1A monoclonal antibody. J Nucl Med 32:1162–1168

    PubMed  CAS  Google Scholar 

  24. LoBuglio AF, Wheeler RH, Trang J, Haynes A, Rogers K, Harvey EB, Sun L, Ghrayeb J, Khazaeli MB (1989) Mouse/human chimeric monoclonal antibody in man: Kinetics and immune response. Proc Natl Acad Sci USA 86:4220–4224

    Article  PubMed  CAS  Google Scholar 

  25. Saga T, Endo K, Akiyama T, Sakahara H, Koizumi M, Watanabe Y, Nakai T, Hosono M, Yamamoto T, Toyoshima K, Konishi J (1991) Scintigraphic detection of overexpressed c-erbB-2 protooncogene products by a class-switched murine anti-c-erbB-2 protein monoclonal antibody. Cancer Res 51:990–994

    PubMed  CAS  Google Scholar 

  26. Divgi CR, Welt S, Kris M, Real FX, Yeh SDJ, Gralla R, Merchant B, Schweighart S, Unger M, Larson SM, Mendelsohn J (1991) Phase I and imaging trial of indium Ill-labeled anti-epidermal growth factor receptor monoclonal antibody 225 in patients with squamous cell lung carcinoma. J Natl Cancer Inst 83:97–104

    Article  PubMed  CAS  Google Scholar 

  27. Kalofonos HP, Pawlikowska TR, Hemingway A, Courtenay-Luck N, Dhokia B, Snook D, Sivolapenko GB, Hooker GR, McKenzie CG, Lavender PJ, Thomas DGT, Epenetos AA (1989) Antibody guided diagnosis and therapy of brain gliomas using radiolabeled monoclonal antibodies against epidermal growth factor receptor and placental alkaline phosphatase. J Nucl Med 30:1636–1645

    PubMed  CAS  Google Scholar 

  28. Bale WF, Spar IL, Goodland RL (1960) Experimental radiation therapy of tumors with 131I carrying antibodies to fibrin. Cancer Res 20:1488–1494

    PubMed  CAS  Google Scholar 

  29. Pezzutto A, Dorken B, Rabinovitch PS, Ledbetter JA, Moldenhauer G, Clark EA (1987) CD 19 monoclonal antibody HD37 inhibits anti-immunoglobulin-induced B cell activation and proliferation. J Immunol 138:2793–2799

    PubMed  CAS  Google Scholar 

  30. Badger CC, Bernstein ID (1986) Prospects for monoclonal antibody therapy of leukemia and lymphoma. Cancer 58:584–589

    Article  PubMed  CAS  Google Scholar 

  31. DeNardo GL, DeNardo SJ, O’Grady LF, Levy NB, Adams GP, Mills SL (1990) Fractionated radioimmunotherapy of B-cell malignancies with 131I-Lym-l. Cancer Res 50 [Suppl]: 1014s-1016s

    Google Scholar 

  32. Parker BA, Vassos AB, Halpern SE, Miller RA, Hupf H, Amox DG, Simoni JL, Starr RJ, Green MR, Royston I (1990) Radioimmunotherapy of human B-cell lymphoma with 90Y-conjugated antiidiotype monoclonal antibody. Cancer Res 50 [Suppl]:1022s-1028s

    PubMed  CAS  Google Scholar 

  33. Goldenberg DM, Horowitz JA, Sharkey RM, Hall TC, Murthy S, Goldenberg H, Lee RE, Stein R, Siegel JA, Izon DO, Burger K, Swayne LC, Belisle E, Hansen HJ, Pinsky CM (1991) Targeting, dosimetry, and radioimmunotherapy of B-cell lymphomas with iodine-131-labeled LL2 monoclonal antibody. J Clin Oncol 9:548–564

    PubMed  CAS  Google Scholar 

  34. Eary JF, Press OW, Badger CC, Durack LD, Richter KY, Addison SJ, Krohn KA, Fisher DR, Porter BA, Williams DL, Martin PJ, Appelbaum FR, Levy R, Brown SL, Miller RA, Nelp WB, Bernstein ID (1990) Imaging and treatment of B-cell lymphoma. J Nucl Med 31:1257–1268

    PubMed  CAS  Google Scholar 

  35. Morton BA, Beatty BG, Mison AP, Wanek PM, Beatty JD (1990) Role of bone marrow transplantation in 90Y antibody therapy of colon cancer xenografts in nude mice. Cancer Res 50 [Suppl]:1008s-1010s

    PubMed  CAS  Google Scholar 

  36. Goodwin DA (1988) Pharmacokinetics and antibodies. J Nucl Med 28: 1358–1362

    Google Scholar 

  37. Wilbur DS, Hadley SW, Hylarides MD, Abrams PG, Beaumier PA, Morgan AC, Reno JM, Fritzberg AR (1989) Development of a stable radioiodinating reagent to label monoclonal antibodies for radiotherapy of cancer. J Nucl Med 30:216–226

    PubMed  CAS  Google Scholar 

  38. Badger CC, Wilbur DS, Hadley SW, Fritzberg AR, Bernstein ID (1990) Biodistribution of p-iodobenzoyl (PIP) labeled antibodies in a murine lymphoma model. Nucl Med Biol 17:381–387

    CAS  Google Scholar 

  39. Zalutsky MR, Narula AS (1988) Radiohalogenation of a monoclonal antibody using an N-succinimidyl 3-(tri-n-butylstannyl) benzoate intermediate. Cancer Res 48:1446–1450

    PubMed  CAS  Google Scholar 

  40. Brady LW, Markoe AM, Woo DV, Amendola BE, Karlsson UL, Rackover M, Koprowski H, Steplewski Z, Peyster RG (1990) Iodine-125-labeled anti-epidermal growth factor receptor-425 in the treatment of glioblastoma multiforme. Ant Immun Radiopharm 24:151–160

    CAS  Google Scholar 

  41. Sharkey RM, Kaltovich FA, Shih LB, Fand I, Govelitz G, Goldenberg DM (1988) Radioimmunotherapy of human colonic cancer xenografts with 90 Y-labeled monoclonal antibodies to Carcinoembryonic antigen. Cancer Res 48:3270–3275

    PubMed  CAS  Google Scholar 

  42. Esteban JM, Hyams DM, Beatty BG, Wanek P, Beatty JD (1989) Effect of yttrium-90-labeled anti-carcinoembryonic antigen monoclonal antibody on the morphology and phenotype of human tumors grown as peritoneal carcinomatosis in athymic mice. Cancer 63:1343–1352

    Article  PubMed  CAS  Google Scholar 

  43. Deshpande SV, DeNardo SJ, Kukis DL, Moi MK, McCall MJ, DeNardo GL, Meares CF (1990) Yttrium-90-labeled monoclonal antibody for therapy: labeling by a new macrocyclic bifunctional chelating agent. J Nucl Med 31:473–479

    Google Scholar 

  44. Vanderheyden J-L, Su F-M, Venkatesan P, Beaumier P, Bugaj J, Fritzberg AR (1990) The chemistry of rhenium-186 labeled antibodies and F(ab’)2 fragments for RIT in animals and man. J Nucl Med 31:823

    Google Scholar 

  45. Cobb LM (1989) Intratumour factors influencing the access of antibody to tumour cells. Cancer Immunol Immunother 28:235–240

    Article  PubMed  CAS  Google Scholar 

  46. Jain RK (1990) Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors. Cancer Res 50 [Suppl]:814s-819s

    PubMed  CAS  Google Scholar 

  47. Fujimori K, Covell DG, Fletcher JE, Weinstein JN (1989) Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab’)2, and Fab in tumors. Cancer Res 49:5656–5663

    PubMed  CAS  Google Scholar 

  48. Skerra A, Pfitzinger I, Pliickthun A (1991) The functional expression of antibody Fv fragments in Escherichia coli: improved vectors and a generally applicable purification technique. Biotechnology 9:273–278

    Article  PubMed  CAS  Google Scholar 

  49. Ward ES, Giissow D, Griffiths AD, Jones PT, Winter G (1989) Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli. Nature 341:544–546

    Article  PubMed  CAS  Google Scholar 

  50. Larson SM (1990) Improved tumor targeting with radiolabeled, recombinant, single-chain, antigenbinding protein. J Natl Cancer Inst 82:1173–1175

    Article  PubMed  CAS  Google Scholar 

  51. Reardan DT, Meares CF, Goodwin DA (1985) Antibody against metal chelates. Nature 316:265–268

    Article  PubMed  CAS  Google Scholar 

  52. Goodwin DA, Meares CF, McCall MJ, McTigue M, Chaovapong W (1988) Pre-targeted immunoscintigraphy of murine tumors with indium-lll-labeled bifunctional haptens. J Nucl Med 29:226–234

    PubMed  CAS  Google Scholar 

  53. Le Doussal J-M, Martin M, Gautherot E, Delaage M, Barbet J (1989) In vitro and in vivo targeting of radiolabeled monovalent and divalent haptens with dual specificity monoclonal antibody conjugates: enhanced divalent hapten affinity for cell-bound antibody conjugate. J Nucl Med 30:1358–1366

    PubMed  Google Scholar 

  54. Le Doussal J-M, Gautherot E, Martin M, Barbet J, Delaage M (1991) Enhanced in vivo targeting of an asymmetric bivalent hapten to double-antigen-positive mouse B cells with monoclonal antibody conjugate cocktails. J Immunol 146:169–175

    PubMed  Google Scholar 

  55. Gridley DS, Ewart KL, Cao JD, Stickney DR (1991) Hyperthermia enhances localization of nlIn-labeled hapten to bifunctional antibody in human colon tumor xenografts. Cancer Res 51:1515–1520

    PubMed  CAS  Google Scholar 

  56. Schuhmacher J, Matys R, Hauser H, Maier-Borst W, Matzku S (1986) Labeling of monoclonal antibodies with a 67Ga-phenolic aminocarboxylic acid chelate: I. Chemistry and labeling technique. Eur J Nucl Med 12:197–404

    Article  Google Scholar 

  57. Matzku S, Moldenhauer G, Kalthoff H, Canevari S, Colnaghi MI, Schuhmacher J, Bihl H (1990) Antibody transport and internalization into tumors. Br J Cancer 62 (S.X):1–5

    CAS  Google Scholar 

  58. Schuhmacher J, Klivenyi G, Hull WE, Matys R, Hauser H, Kalthoff H, Schmiegel W, Maier-Borst W, Matzku S (1992) A bifunctional HBED-derivative for labeling of antibodies with Ga, In and Fe. Comparative biodistribution in mice bearing antibody internalizing and non-internalizing tumors. Nucl Med Biol (in press)

    Google Scholar 

  59. Hnatowich DJ, Virzi F, Ruschkowski M (1987) Investigations of avidin and biotin for imaging applications. J Nucl Med 28:1294–1302

    PubMed  CAS  Google Scholar 

  60. Paganelli G, Pervez S, Siccardi AG, Rowlinson G, Deleide G, Chiolerio F, Malcovati M, Scassellati GA, Epenetos A A (1990) Intraperitoneal radio-localization of tumors pre-targeted by biotinylated monoclonal antibodies, Int J Cancer 45:1184–1189

    Article  PubMed  CAS  Google Scholar 

  61. Paganelli G, Magnani P, Rossetti C, Zito F, Belloni C, Pasini A, Sassi I, Sanvito F, Siccardi AG, Fazio F (1990) Antibody guided tumor detection in CEA positive patients using the avidin-biotin system. J Nucl Med 31:735 (abstr)

    Google Scholar 

  62. Schatten C, Pateisky N, Vavra N, Ehrenbock P, Angelberger P, Sivolapenko G, Epenetos A (1991) Lymphoscintigraphy with 123I-labelled epidermal growth factor. Lancet 337:395–396

    Article  PubMed  CAS  Google Scholar 

  63. Lamberts SWJ, Bakker WH, Reubi JC, Krenning EP (1990) Somatostatin receptor imaging in the localization of endocrine tumors. N Engl J Med 323:1246–1249

    Article  PubMed  CAS  Google Scholar 

  64. Bakker WH, Krenning EP, Breeman WA, Kooij PP, Reubi JC, Koper JW, deJong M, Lameris JS, Vieers TJ, Lamberts SW (1991) The in vivo use of a radioiodinated somatostatin analogue: dynamics, metabolism, and binding to somatostatin receptor-positive tumors in man. J Nucl Med 32:1184–1188

    PubMed  CAS  Google Scholar 

  65. Larson SM (1991) Receptors on tumors studies with radionuclide scintigraphy. J Nucl Med 32:1189–1191

    PubMed  CAS  Google Scholar 

  66. Order SE, Stillwagon GB, Klein JL, Leichner PK, Siegelman SS, Fishman EK, Ettinger DS, Haulk T, Kopher K, Finney K, Surdyke M, Self S, Leibel S (1985) Iodine 131 antiferritin, a new treatment modality in hepatoma: a Ratiation Therapy Oncology Group Study J Clin Oncol 3:1573–1582

    PubMed  CAS  Google Scholar 

  67. Rosen ST, Zimmer AM, Goldman-Leikin R, et al. (1987) Radio-immunodetection and radioimmunotheraphy of cutaneous T-cell lymphomas using an I-131-labeled monoclonal antibody: an Illinois Cancer Council study. J Clin Oncol 5:562–573

    PubMed  CAS  Google Scholar 

  68. Press OW, Eary JF et al. (1989) Treatment of refractory NHLs with radiolabeled MB-1 (anti-CD37) antibody. J Clin Oncol 7:1027–1038

    PubMed  CAS  Google Scholar 

  69. Bergh J, Nilsson S, Liljedahl C, Sivolapenko G, Maripuu E, Stavrou D, Epenetos A (1990) In vivo imaging and treatment of human brain tumours utilizing the radiolabeled monoclonal antibody MUC 2–63 Anticancer Res 10:655–660

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abteilung Immunchemie, Pharmaforschung E. Merck, Frankfurter Straße 250, W-6100, Darmstadt, Germany

    S. Matzku

  2. Klinik für Nuklearmedizin, Katharinenhospital, W-7000, Stuttgart, Germany

    H. Bihl

Authors
  1. S. Matzku
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Bihl
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Abteilung für Klinische Chemie, Medizinische Klinik, Universitäts-Krankenhaus Eppendorf, Martinistraße 52, W-2000, Hamburg 20, Germany

    Christoph Wagener

  2. Diagnostische Forschung E. Merck, Frankfurter Straße 250, W-6100, Darmstadt, Germany

    Siegfried Neumann

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Matzku, S., Bihl, H. (1993). Tumor Localization by Immunoscintigraphy: Potential and Limitations. In: Wagener, C., Neumann, S. (eds) Molecular Diagnostics of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77521-5_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-77521-5_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55476-9

  • Online ISBN: 978-3-642-77521-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation