Tumor Localization by Immunoscintigraphy: Potential and Limitations

  • S. Matzku
  • H. Bihl
Conference paper


It is worth remembering that positive tumor localization with labeled antibodies was one of the founder technologies of nuclear medicine (for review see [1]). However, the enthusiastic approaches in the 1950s were abandoned when it became clear that the target structures detected by the then available polyclonal antitumor antisera were not actually tumor-specific at all, but, for example, directed against ectopic normal components such as peritumoral fibrin [2–4]


Label Antibody Artificial Receptor Bifunctional Chelate Agent Growth Factor Receptor Monoclonal Antibody Monoclonal Antibody Conjugate 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • S. Matzku
    • 1
  • H. Bihl
    • 2
  1. 1.Abteilung ImmunchemiePharmaforschung E. MerckDarmstadtGermany
  2. 2.Klinik für NuklearmedizinKatharinenhospitalStuttgartGermany

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