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MHC Molecules in Thymic Development and Selection of the T Cell Repertoire

  • Chapter
The HLA System in Clinical Transplantation

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Abstract

The hallmark of the immune system is its ability to discriminate between self and non-self (foreign) products. The T cell is the prime player in this respect during the cellular immune response. The thymus provides both the environment and the support for T cells to be “educated” in self-nonself recognition. The thymus has been aptly called the “black box” because of the complexity of its role in this process. Indeed, much light has been cast upon the arcane processes of the thymus that lead to the elimination of self-reactive T cells and yet, at same time, enable it to maintain an optimum set of immune-responsive cells that can react with the whole universe of foreign antigens that assail the body during an entire lifetime.

“The light has come upon the dark benighted way”.

Dickens

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Authors
  1. D. R. Koh
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  2. T. W. Mak
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Editors and Affiliations

  1. Department Group for Laboratory Medicine, University of Oslo Rikshospitalet, Pilestredet 32, 0027, Oslo, Norway

    Bjarte G. Solheim

  2. Department of Microbiology and Immunology, New York Medical College, 10595, Valhalla, NY, USA

    Soldano Ferrone

  3. Department for Clinical Immunology, Huddinge sjukhus, 141 86, Huddinge, Sweden

    Erna Möller

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© 1993 Springer-Verlag Berlin Heidelberg

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Koh, D.R., Mak, T.W. (1993). MHC Molecules in Thymic Development and Selection of the T Cell Repertoire. In: Solheim, B.G., Ferrone, S., Möller, E. (eds) The HLA System in Clinical Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77506-2_9

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  • DOI: https://doi.org/10.1007/978-3-642-77506-2_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77508-6

  • Online ISBN: 978-3-642-77506-2

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