Abstract
Transplantation or histocompatibility antigens were originally defined histogenically in vivo by exchanging tissue grafts between genetically dissimilar inbred strains of mice, their Fl, F2 hybrid and backcross (BC) progeny (Snell 1948). When two parental strains, PI and P2, reject each other’s grafts, both strains reject grafts from their F1 hybrid progeny, whereas F1 recipients accept grafts from either parental strain and all F2 and BC progeny (Fig. 1). These results established that transplantation antigens were eodominantly expressed. From the very small numbers of F 2 or BC donors whose grafts could be accepted by the parental strains, it was clear that a number of different histocompatibility (H) antigens were independently segregating. They were named sequentially H-l, H-2, H-3, etc., as they were identified and isolated by further backcrossing. The strongest of these, H-2, which elicited the most rapid graft rejection, was found to react with antibodies raised by Gorer using immunisation between inbred mouse strains: Gorer et al. (1948) then laid the foundation of serological analysis of the genetics and polymorphism of what we now know as the major histocompatibility complex (MHC), H-2 in mouse (Klein 1975), which has homologues in all mammalian species, including the human HLA system.
Keywords
- Major Histocompatibility Complex
- Major Histocompatibility Complex Class
- Major Histocompatibility Complex Molecule
- Inbred Mouse Strain
- Mixed Lymphocyte Culture
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
The work in our laboratory on minor H antigens is supported in part by the Cancer Research Campaign and by the MRC.
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References
Abe R, Foo-Phillips M, Hodes RJ (1989) Analysis of Mlsc genetics. A novel instance of genetic redundancy. J Exp Med 170:1059–1073
Acha-Orbea H, Mitchell DJ, Timmermann L, Wraith DC, Tausch GS, Waldor MK, Zamvil SS, McDevitt HO, Steinman L (1988) Limited heterogeneity of T cell receptors from lymphocytes mediating auto-immune encephalomyelitis allows specific immune intervention. Cell 54:263–273
Bailey DW (1971) Brief communication: cumulative effect or independent effect? Transplantation 11:419–422
Bailey DW (1975) Genetics of histocompatibility in mice. I. New loci and congenic lines. Immunogenetics 2:249–256
Bernhard EJ, Le AT, Yannelli JR, Holterman MJ, Hogan KT, Parham P, Engelhard VH (1987) The ability of cytotoxic T cells to recognise HLA-A2 or HLA-B7 antigens expressed on murine cells correlates with their epitope specificity. J Immunol 139:3614–3621
Bevan MJ (1975) The major histocompatibility complex determines susceptibility to cytotoxic T cells directed against minor histocompatibility antigens. J Exp Med 142:1349–1364
Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JC, Wiley DC (1987a) Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329:506–512
Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JC, Wiley DC (1987b) The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329:512–518
Blackman M, Kappler J, Marraek P (1990) The role of the T cell receptor in positive and negative selection of developing T cells. Science 248:1335–1341
Cepellini R, Mattiuz PL, Scudeller G, Visetti M (1969) Experimental allotransplantation in man. I. The role of the HLA system in different genetic combinations. Transplant Proc 1:385–389
Choi Y, Kotzin B, Herron L, Callahan J, Marraek P, Kappler J (1989) Interaction of Staphylococcus aureus toxin “superantigens” with human T cells. Proc Natl Acad Sci USA 86:8941–8945
Cochet M, Casrouge A, Dumont A-M, Transy C, Baleux F, Maloy WL, Coligan JE, Cazenave P-A, Kourilsky P (1989) A new cell surface molecule closely related to mouse class I transplantation antigens. Eur J Immunol 19:1927–1931
Cohen JC, Varmus HE (1979) Endogenous mammary tumour virus DNA varies among wild mice and segregates during inbreeding. Nature 278:418–423
Cook RG, Jenkins RN, Flaherty L, Rich RR (1983) The Qa-1 alloantigens. II. Evidence for the expression of two Qa-1 molecules by the Qa-ld genotype and for cross-reactivity between Qa-1 and H-2K. J Immunol 130:1293–1299
Davis AP, Roopenian DC (1990) Complexity at the mouse minor histocompatibility locus H-4. Immunogenetics 31:7–12
Dyson PJ, Knight AM, Fairchild S, Simpson E, Tomonari K (1991) Co-segregation of genes encoding ligands responsible for T cell receptor Vβll deletion with Mtv genomes. Nature 349:531–532
Eichwald EJ, Silmser CR (1955) Communication. Transplant Bull 2:148–149
Festenstein H (1973) Immunogenetic and biological aspects of in vitro lymphocyte allotransformation (MLR) in the mouse. Transplant Rev 15:62–88
Frankel WN, Rudy C, Coffin JM, Huber BT (1991) Linkage of Mis genes to endogenous mammary tumour viruses of inbred mice. Nature 349:526–529
Gasser DL, Silvers WK (1972) Genetics and immunology of sex-linked antigens. Adv Immunol 15:215–247
Gordon RD, Simpson E, Samelson L (1975) In vitro cell-mediated immune responses to the male specific (H-Y) antigen in mice. J Exp Med 142:1108–1120
Gorer PA, Lyman S, Snell GD (1948) Studies on the genetic and antigenic basis of tumour transplantation linkage between a histocompatibility gene and ‘fused’ in mice. Proc Soc Lond [Biol] 135:499–505
Goulmy E (1988) Minor histocompatibility antigens in man and their role in transplantation. Transplant Rev 2:29–54
Happ MP, Woodland DL, Palmer E (1989) A third T cell receptor β-chain variable region gene encodes reactivity to Mls-la gene products. Proc Natl Acad Sci USA 86:6293–6296
Jenkins NA, Copeland NG, Ihylor BA, Lee BK (1981) Dilute(d) coat color mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome. Nature 293:370–374
Kappler JW, Roehm N, Marraek P (1987) T cell tolerance by clonal elimination in the thymus. Cell 49:273–280
Kappler JW, Staerz U, White J, Marraek PC (1988) Self-tolerance eliminates T cells specific for Mis-modified products of the major histocompatibility complex. Nature 332:35–40
Kisielow P, Bluthmann H, Staerz UD, Steinmetz M, von Boehmer H (1988) Tolerance in T-cell receptor transgenic mice involves deletion of non-mature CD4+8+ thymocytes. Nature 333:742–746
Klein J (1975) Biology of the mouse histocompatibility-2 complex. Springer, Berlin Heidelberg New York
Kozak C, Peters G, Pauley R, Morris V, Miehalides R, Dudley J, Green M, Davisson M, Prakash O, Vaidya A, Hilgers J, Verstraeten A, Hynes N, Diggelmann H, Peterson D, Cohen JC, Dickson C, Sarkar N, Nusse R, Varmus H, Callahan R (1987) A standardised nomenclature for endogenous mouse mammary tumor viruses. J Virol 61:1651–1654
Ljunggren H-G, Stam NJ, Ohlen C, Neefjes JJ, Hoglund P, Heemels M-T, Bastin J, Schumacher TNM, Townsend A, Karre K, Ploegh HL (1990) Empty MHC class I molecules come out in the cold. Nature 346:476–480
Lombardi G, Sidhu S, Lamb JR, Batchelor JR, Lechler R (1988) Co-recognition of endogenous peptide with HLA-DR1 by alloreactive human T cell clones. J Immunol 142:753–759
Loveland B, Simpson E (1986) The non-MHC transplantation antigens reviewed: neither weak nor minor. Immunol Today 7:223–229
MacDonald HR, Schneider R, Lees RK, Howe RC, Acha-Orbea H, Festenstein H, Zinkernagel RM, Hengartner H (1988) T cell receptor Vβ use predicts reactivity and tolerance to Mlsa-en-coded antigens. Nature 332:40–45
Maloy WL, Coligan JE (1982) Primary strucutre of the H-2Db alloantigen. Immunogenetics 16:11–22
Marrack P, Kushnir E, Kappler J (1991) A maternally inherited superantigen encoded by a mammary tumour virus. Nature 349:524–526
Matzinger P, Bevan M J (1977) Why do so many lymphocytes respond to the major histocompatibility antigens? Cell Immunol 29:1–5
Matzinger P, Zamoyska R, Waldmann H (1984) Self-tolerance is H-2-restricted. Nature 308:738–741
Mellor AL, Antoniou J, Robinson PJ (1985) Structure and expression of genes encoding murine Qa-2 class I antigens. Proc Natl Acad Sci USA 82:5920–5924
Meruelo D, Rossomando A, Offer M, Buxbaum J, Pellicer A (1983) Association of endogenous viral loci with genes encoding murine histocompatibility and lymphocyte differentiation antigens. Proc Natl Acad Sci USA 80:5032–5036
Okada CY, Holzmann B, Guidos C, Palmer E, Weissman IL (1990) Characterisation of a rat monoclonal antibody specific for a determinant encoded by the Vβ7 gene segment. Depletion of Vβ7+ T cells in mice with Mls-la haplotype. J Immunol 144:3473–3477
O’Neill AE, Reid K, Garberi JC, Karl M, Flaherty L (1986) Extensive deletions in the Q region of the mouse major histocompatibility complex. Immunogenetics 24:368–373
Peters G, Placzek M, Brookes S, Kozak C, Smith R, Dickson C (1986) Characterisation, chromosome assignment and segregation analysis of endogenous proviral units of mouse mammary tumor virus. J Virol 59:535–544
Pullen AM, Marrack P, Kappler JW (1988) The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens. Nature 335:796–801
Pullen AM, Marrack P, Kappler JW (1989) Evidence that Mls-2 antigens which delete Vβ3+ T cells are controlled by multiple genes. J Immunol 142:3033–3037
Pullen AM, Wade T, Marrack P, Kappler JW (1990) Identification of the region of T cell receptor β chain that interacts with the self-superantigen Mls-la. Cell 61:1365–1374
Robinson PJ, Lefkovits I, Fischer Lindahl K (1987) Molecular complexity of Qa-2 antigens demonstrated by two-dimensional gel electrophoresis. J Immunogenet 14:81–87
Roopenian DC, Davis AP (1989) Responses against antigens encoded by the H-3 histocompatibility locus: antigens stimulating class I MHC-and class II MHC-restricted T cells are encoded by separate genes. Immunogenetics 30:335–343
Rotzschke O, Falk K, Wallny H J, Faath S, Rammensee HG (1990) Characterisation of naturally occuring minor histocompatibility peptides including H-4 and H-Y. Science 249:283–287
Scott D, McLaren A, Dyson J, Simpson E (1991) Variable spread of X inactivation affecting the expression of different epitopes of the Hya gene product in mouse B-cell clones. Immunogenetics 33:54–61
Sha WC, Nelson CA, Newberry RD, Kranz DM, Russell JH, Loh DY (1988) Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 336:73–76
Simpson E (1982) The role of H-Y as a minor transplantation antigen: Immunol Today 3:97–106
Simpson E (1984) H-2 and non H-2 Ir genes. Ann Inst Pasteur Immunol 135C:410
Simpson E (1986) T and B lymphocytes: two repertoires or one? Immunol Lett 12:185–193
Snell GD (1948) Methods for the study of histocompatibility genes. J Genet 49:87–103
Snell GD (1956) A comment on Eichwald and Silmser’s communication. Transplant Bull 3:29
Tomonari K (1983) Antigen and MHC restriction specificity of two types of cloned male-specific T cell lines. J Immunol 131:1641–1645
Tomonari K (1990) Linkage between Tcrb-V and a gene responsible for deletion of Tcrb-Vll+ T cells. Immunogenetics 32:60–62
Tomonari K, Fairchild S (1990) Positive selection of Tcrb-V4+CD8+ T cells by H-2d molecules. Immunogenetics 32:290–292
Tomonari K, Fairchild S (1991) The genetic basis of negative selection of Terb-Vll+ T cells. Immunogenetics 33:157–162
Townsend ARM, Rothbard J, Gotch FM, Bahadur G, Wraith D, McMichael AJ (1986) The epitopes of influenza nucleoprotein recognised by cytotoxic T lymphocytes can be defined by short synthetic peptides. Cell 44:959–968
Van Els CACM, Bakker A, Zwinderman AH, Zwaan FE, van Rood JJ, Goukny E (1990a) Effector mechanisms in graft-vs-host disease in response to minor histocompatibility antigens. I. Absence of correlation with cytotoxic effector cells. Transplantation 50:62–66
Van Els CACM, Bakker A, Zwinderman AH, Zwaan FE, van Rood J J, Goulmy E (1990b) Effector mechanisms in graft-vs-host disease in response to minor histocompatibility antigens. II. Evidence for a possible involvement of proliferative T cells. Transplantation 50:67–71
Vidovic D, Matzinger P (1988) Unresponsiveness to a foreign antigen can be caused by self-tolerance. Nature 336:222–225
White J, Herman A, Pullen AM, Kubo R, Kappler JW, Marrack P (1989) The Vβ-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell 56:27–35
Woodland D, Happ MP, Bill J, Palmer E (1990) Requirement for cotolerogenic gene products in the clonal deletion of I-E reactive T-cells. Science 247:964–967
Woodland DL, Happ MP, Gollob KJ, Palmer E (1991) An endogenous retrovirus mediating deletion of αβ T cells? Nature 349:529–531
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Simpson, E. (1993). Minor Transplantation Antigens. In: Solheim, B.G., Ferrone, S., Möller, E. (eds) The HLA System in Clinical Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77506-2_7
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DOI: https://doi.org/10.1007/978-3-642-77506-2_7
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