Abstract
Prolonged or heavy immunosuppressive therapy used in organ transplantation is complicated by the development of an unusual assortment of cancers (Penn 1989). This chapter is based on reports of 5233 patients who developed 5571 different malignancies after transplantation and who were reported to the Cincinnati Transplant Tumor Registry (CTTR) up to January 1991. Of these, 4723 had received kidney, 306 heart, 111 liver, 65 bone marrow, 15 pancreas, 8 combined heart and lung, 3 lung, and 2 clusters of upper abdominal organs.
Supported in part by a grant from the Veterans Administration
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References
Blohme I, Brynger H (1985) Malignant disease in renal transplant patients. Transplantation 39:23–25
Brunson ME, Balakrishnan K, Penn I (1990) HLA and Kaposi’s sarcoma in solid organ transplantation. Hum Immunol 29(l):56–63
Hanto DW, Birkenbach M, Frizzera G, Gajl-Peczalska KJ, Simmons RL, Schubach WH (1989) Confirmation of the heterogeneity of post-transplant Epstein-Barr virus-associated B cell proliferations by immunoglobulin gene rearrangement analyses. Transplantation 47:458–464
Kinlen LJ (1985) Incidence of cancer in rheumatoid arthritis and other disorders after immunosuppressive treatment. Am J Med 78(1A):44–49
Nalesnik MA, Makowka L, Starzl TE (1988) The diagnosis and treatment of posttransplant lymphoproliferative disorders. Curr Probl Surg 25:371–472
Penn I (1989) Why do immunosuppressed patients develop cancer. In: Pimentel E (ed) CRC Critical reviews in oncogenesis. CRC, Boca Raton, pp 27–52
Penn I (1991) The changing patterns of posttransplant malignancies. Transplant Proc 23:1101–1103
Penn I, Brunson ME (1988) Cancers following cyclosporine therapy. Transplant Proc [Suppl 3] 20:885–892
Sheil AGR, Flavel S, Disney APS, Mathew TH, Hall BM (1987) Cancer incidence in renal transplant patients treated with azathioprine and cyclosporine. Transplant Proc 19:2214–2216
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© 1993 Springer-Verlag Berlin Heidelberg
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Penn, I. (1993). Tumors in Transplanted Patients. In: Solheim, B.G., Ferrone, S., Möller, E. (eds) The HLA System in Clinical Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77506-2_31
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DOI: https://doi.org/10.1007/978-3-642-77506-2_31
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-77508-6
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