Abstract
Xenogeneic transplantation is the transplantation of organs between members of different species. The recent improvements in immunosuppression and the current high success rate of clinical allogeneic transplantation have inspired a search for new donors and thus a resurgence of interest in xenogeneic transplantation. In this chapter we will discuss of the immunologic issues of xenografting including: the differences in major histocompatibility complex (MHC) antigens between species; the recognition of these xeno-MHC antigens compared to allo-MHC antigens; and the potential implications of the different processes of xenorecognition on the mechanisms of xenograft rejection. Overall, our purpose is to address the question of whether xenogeneic transplantation is feasible.
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© 1993 Springer-Verlag Berlin Heidelberg
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Buyske, J., Auchincloss, H. (1993). Xenografting: Is It Feasible?. In: Solheim, B.G., Ferrone, S., Möller, E. (eds) The HLA System in Clinical Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77506-2_30
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DOI: https://doi.org/10.1007/978-3-642-77506-2_30
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-77508-6
Online ISBN: 978-3-642-77506-2
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