Skip to main content
SpringerLink
Log in
Book cover

The HLA System in Clinical Transplantation pp 366–372Cite as

Marrow Transplantation from Unrelated Donors

  • Chapter

  • 116 Accesses

Abstract

As bone marrow transplantation has evolved into the treatment of choice for many hematologic malignancies (Storb et al. 1984; Goldman et al. 1986; Thomas 1983), the lack of HLA-identical sibling donors for most patients has become a major issue. Given the current average family size in the USA of approximately 2.7 children, only 35% of patients can anticipate having an HLA-identical sibling (Nesbit et al. 1987; Appelbaum et al. 1986). For this reason, many centers have begun exploring the use of HLA-matched or HLA-similar unrelated volunteer donors.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Anasetti C, Amos D, Beatty PG, et al. (1989) Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma. N Engl J Med 320:197

    Article  PubMed  CAS  Google Scholar 

  • Appelbaum FR, Hewlett J, Kopecky K, et al (1986) Prospective cooperative study of bone marrow transplantation versus continued chemotherapy for adult nonlymphocytic leukemia: a Southwest Oncology Group Study (Abstr). Blood 68:216a

    Google Scholar 

  • Ash RC, Casper JT, Chitambar CR, et al (1990) Successful allogeneic transplantation of T-cell-depleted bone marrow from closely HLA-matched unrelated donors. N Engl J Med 322:485–494

    Article  PubMed  CAS  Google Scholar 

  • Beatty PG, Clift RA, Mickelson EM, et al (1985) Marrow transplantation from related donors other than HLA-identical siblings. N Engl J Med 313:765

    Article  PubMed  CAS  Google Scholar 

  • Beatty PG, Dahlberg S, Mickelson EM, et al (1988) Probability of finding HLA-matched unrelated marrow donors. Transplantation 45:714

    Article  PubMed  CAS  Google Scholar 

  • Beatty PG, Layrisse Z, van Seventer GA, et al (1989 a) T-cell recognition of HLA Class I determinants. In: Dupont B (ed) Immunogenetics and histocompatibility. Springer, Berlin Heidelberg New York, pp 359–362 (Immunobiology of HLA, vol 2)

    Google Scholar 

  • Beatty PG, Atcher C, Hess E, et al (1989b) Recruiting blood donors into a local bone marrow donor registry. Transfusion 29:778

    Article  PubMed  CAS  Google Scholar 

  • Beatty PG, Hansen JA, Longton GM, et al (1991) Marrow transplantation from HLA-matched unrelated donors for treatment of hematologic malignancies. Transplantation 51:443

    Article  PubMed  CAS  Google Scholar 

  • Choo SY, Antonelli P, Nisperos B, et al (1986) Six variants of HLA-B27 identified by isoelectric focusing. Immunogenetics 23:24

    Article  PubMed  CAS  Google Scholar 

  • Dill O, Kievits F, Koch S, et al (1988) Immunologic function of HLA-C antigens in HLA-Cw3 transgenic mice. Proc Natl Acad Sci USA 85:5664

    Article  PubMed  CAS  Google Scholar 

  • Duquesnoy RJ, Zeevi A, Marrari M, et al (1983) Bone marrow transplantation for severe aplastic anemia using a phenotypically HLA-identical SB-compatible unrelated donor. Transplantation 35:566–571

    Article  PubMed  CAS  Google Scholar 

  • Fleischhauer K, Kernan NA, O’Reilly RJ, et al (1990) Bone marrow-allograft rejection by T lymphocytes recognizing a single amino acid difference in HLA-B44. N Engl J Med 323:1818–1822

    Article  PubMed  CAS  Google Scholar 

  • Foroozonfar N, Hobbs JR, Hugh-Jones K, et al (1977) Bone marrow transplant from an unrelated donor for chronic granulomatous disease. Lancet 1:210–213

    Google Scholar 

  • Gingrich RD, Howe CWS, Goeken NE, et al (1985) The use of partially matched, unrelated donors in clinical bone marrow transplantation. Transplantation 39:526

    Article  PubMed  CAS  Google Scholar 

  • Gingrich RD, Ginder GD, Goeken NE, et al (1988) Allogeneic marrow grafting with partially mismatched, unrelated marrow donors. Blood 71:1375–1381

    PubMed  CAS  Google Scholar 

  • Goldman JM, Apperley J, Jones L, et al (1986) Bone marrow transplantation for patients with chronic myeloid leukemia. N Engl J Med 314:202

    Article  PubMed  CAS  Google Scholar 

  • Gordon-Smith EC, Fairhead SM, Chipping SM, et al (1982) Bone-marrow transplantation for severe aplastic anemia using histocompatible unrelated volunteer donors. Br Med J 285:835–837

    Article  CAS  Google Scholar 

  • Goulmy E (1988) Minor histocompatibility antigens in man and their role in transplantation. In: Morris PJ, Tilney NL (eds) Transplant reviews. Saunders, Philadelphia, p 29

    Google Scholar 

  • Hansen JA, Clift RA, Thomas ED, et al (1980) Transplantation of marrow from an unrelated donor to a patient with acute leukemia. N Engl J Med 303:565–567

    Article  PubMed  CAS  Google Scholar 

  • Horowitz SD, Groshong T, Bach FH, et al (1975) Treatment of severe combined immunodeficiency with bone marrow from an unrelated mixed-leucocyte-culture-nonreactive donor. Lancet 2:431–433

    Article  PubMed  CAS  Google Scholar 

  • Hows JM, Yin JL, Marsh J, et al (1986) Histocompatible unrelated volunteer donors compared with HLA nonidentical family donors in marrow transplantation for aplastic anemia and leukemia. Blood 68:1322–1328

    PubMed  CAS  Google Scholar 

  • Koller B, Geraghty D, Shimizu Y, et al (1988) A novel HLA class I gene expressed in resting T lymphocytes. J Immunol 141:897

    PubMed  CAS  Google Scholar 

  • Lohrmann H-P, Dietrich M, Goldmann SF, et al (1975) Bone marrow transplantation for aplastic anemia from a HLA and MLC-identical unrelated donor. Blut 31:347–354

    Article  PubMed  CAS  Google Scholar 

  • Mathe G, Schwarzenberg L (1976) Treatment of bone marrow aplasia by mismatched bone marrow transplantation after conditioning with antilymphocyte globulin: Long-term results. Transplant Proc 8:595–602

    PubMed  CAS  Google Scholar 

  • McGlave PB (1990) Unrelated marrow transplants for CML. International Society for Experimental Hematology, Seattle, August

    Google Scholar 

  • McGlave P, Scott E, Ramsay N, et al (1987) Unrelated donor bone marrow transplantation therapy for chronic myelogenous leukemia. Blood 70:877–881

    PubMed  CAS  Google Scholar 

  • McGlave PB, Beatty PG, Ash R, et al (1990) Therapy for chronic myelogenous leukemia with unrelated donor bone marrow transplantation: results in 102 cases. Blood 75:1728

    PubMed  CAS  Google Scholar 

  • Nesbit M, Buckley J, Lampkin B, et al (1987) Comparison of allogeneic bone marrow transplantation (BMT) with maintenance chemotherapy in previously untreated childhood acute non-lymphocytic leukemia (ANLL) (abstract). Proc Am Soc Clin Oncol 6:640a

    Google Scholar 

  • O’Reilly RJ, Dupont B, Pahwa S, et al (1977) Reconstitution in severe combined immunodeficiency by transplantation of marrow from an unrelated donor. N Engl J Med 297:1311–1318

    Article  PubMed  Google Scholar 

  • Park BH, Biggar WD, Good RA (1975) Transplantation of incompatible bone marrow in infants with severe combined immunodeficiency disease. Birth Defects 11:380–384

    PubMed  CAS  Google Scholar 

  • Speck B, Zwaan FE, van Rood J J, et al (1973) Allogeneic bone marrow transplantation in a patient with aplastic anemia using a phenotypically HLA-A identical unrelated donor. Transplantation 16:24–28

    Article  PubMed  CAS  Google Scholar 

  • Storb R, Thomas ED, Buckner CD, et al (1984) Marrow transplantation for aplastic anemia. Semin Hematol 21:27

    PubMed  CAS  Google Scholar 

  • Takahashi K, Juji T, Miyazaki H (1989) Determination of an appropriate size on unrelated donor pool to be registered for HLA-matched bone marrow transplantation. Transfusion 29:311

    Article  PubMed  CAS  Google Scholar 

  • Thomas ED (1983) Marrow transplantation for malignant disease. (Karnofsky Memorial Lecture). J Clin Oncol 1:517

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. P. G. Beatty
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department Group for Laboratory Medicine, University of Oslo Rikshospitalet, Pilestredet 32, 0027, Oslo, Norway

    Bjarte G. Solheim

  2. Department of Microbiology and Immunology, New York Medical College, 10595, Valhalla, NY, USA

    Soldano Ferrone

  3. Department for Clinical Immunology, Huddinge sjukhus, 141 86, Huddinge, Sweden

    Erna Möller

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Beatty, P.G. (1993). Marrow Transplantation from Unrelated Donors. In: Solheim, B.G., Ferrone, S., Möller, E. (eds) The HLA System in Clinical Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77506-2_28

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-77506-2_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77508-6

  • Online ISBN: 978-3-642-77506-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation