Abstract
Bone marrow transplantation (BMT) is a well established therapy for some hematological malignancies, especially leukemia, severe aplastic anemia, and severe metabolic disorders (Thomas et al. 1975; Groth and Ringden 1984). Experimental data in animals paved the way for subsequent clinical attempts. Jacobson and coworkers (1949) found that mice exposed to normally lethal irradiation survived if the spleen was shielded. Later it was demonstrated that mice could be saved by parenteral administration of syngeneic marrow following lethal irradiation. In 1957, Thomas and coworkers reported that bone marrow could be infused intravenously with safety in humans. The first successful BMTs were performed using identical twins as donors. With other types of donors graft host disease (GVHD) was a major problem. After the discovery of the major histocompatibility complex in humans, the HLA system, it became possible to give marrow from HLA-identical sibling donors.
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© 1993 Springer-Verlag Berlin Heidelberg
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Ringdén, O. (1993). Bone Marrow Transplantation Using Related Donors. In: Solheim, B.G., Ferrone, S., Möller, E. (eds) The HLA System in Clinical Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77506-2_27
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DOI: https://doi.org/10.1007/978-3-642-77506-2_27
Publisher Name: Springer, Berlin, Heidelberg
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