Transplantation Tolerance and Noninherited Maternal HLA Antigens

  • F. H. J. Claas
  • L. Zhang
  • J. J. van Rood

Abstract

Matching of donor and recipient with regard to their HLA antigens is one of the well-established factors influencing kidney graft survival. In the first 5-6 months after transplantation a dominant role for HLA-DR matching has been described, while the effect of matching for HLA class I antigens, mainly the B locus antigens, continues to be important for at least 3 years (Thorogood et al. 1990; Gilks et al. 1990).

Keywords

Cyclosporin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bean MA, Mickelson E, Yanagida J, Ishioka S, Brannen GE, Hansen JA (1990) Suppressed antidonor MIC responses in renal transplant candidates conditioned with donor-specific transfusions that carry the recipients’ noninherited maternal HLA haplotype. Transplantation 49:382–386PubMedCrossRefGoogle Scholar
  2. Billingham RE, Brent L, Medawar PB (1953) “Actively acquired tolerance” of foreign cells. Nature 172:603–606Google Scholar
  3. Bradley BA, Klouda PT, Ray TC (1985) Negative crossmatch selection of kidney for highly sensitized patients. Transplant Proc 17:2465–2467Google Scholar
  4. Campbell DA, Lorber MI, Swecton JC, Turcotte JG, Niederhuber JE, Beer AE (1984) Breast feeding and maternal-donor renal allografts. Transplantation 37:340–344PubMedCrossRefGoogle Scholar
  5. Claas FHJ, Gijbels Y, van der Velden-de Munck S, van Rood J J (1988) Induction of B cell unresponsiveness to non-inherited maternal antigens during fetal life. Science 241:1815–1817PubMedCrossRefGoogle Scholar
  6. Claas FHJ, de Waal LP, Beelen J, Reekers P, van de Berg-Loonen E, de Gast E, d’Amaro J, Persijn GG, Zantvoort F, van Rood JJ (1990) Transplantation of highly sensitized patients on the basis of acceptable mismatches. In: Terasaki PI (ed) Clinical transplants 1989. UCLA, Los Angeles, pp 185–190Google Scholar
  7. Fluit L, Reekers P, Claas FHJ (1989) Are maternal HLA antigens protective for antibody formation. Transplant Proc 21:689–690PubMedGoogle Scholar
  8. Gilkes WR, Gore SM, Bradley BA (1990) Renal transplant rejection. Transient immunodominance of HLA mismatches. Transplantation 50:141–145CrossRefGoogle Scholar
  9. Hadley GA, Phelan D, Duffy BF, Mohanakumar T (1990) Lack of T cell tolerance of non-inherited maternal HLA antigens in normal humans. Hum Immunol 28:373–381PubMedCrossRefGoogle Scholar
  10. Herzog WR, Zanter B, Irschick E, Huber C, Franz HE, Wagner H, Kabelitz D (1987) Selective reduction of donor-specific cytotoxic T lymphocyte precursors in patients with a well-functioning kidney allograft. Transplantation 43:384–389PubMedCrossRefGoogle Scholar
  11. Irschick E, Miller K, Berger M, Schönetzer D, Koller J, Wagner H, Goftinger W, Huber C (1989) Studies of the mechanism of tolerance induced by short term immunosuppression with cyclosporin in high risk corneal allograft recipient. I. Analsis of CTL precursor frequencies. Transplantation 48:986–990PubMedCrossRefGoogle Scholar
  12. Kaminsky E, Hows J, Man S, Brookes P, Mackinnon S, Hughes T, Arakian O, Goldman JM (1989) Prediction of graft-versus-host disease by frequency analysis of cytotoxic T cells after unrelated donor bone marrow transplantation. Transplantation 48:608–613Google Scholar
  13. Palmer A, Taube D, Welsh KJ, Bewick M, Gjorstrup P, Thick M (1989) Removal of anti-HLA antibodies by extracorporeal immunoabsorption to enable renal transplantation. Lancet 1:10–12PubMedCrossRefGoogle Scholar
  14. Phelan D, Hadley G, Duffy B, Mohanam S, Mohanakumar T (1991) Anti-idiotypic antibodies to HLA class I alloantibodies in normal individuals: a mechanism of tolerance to non-inherited maternal HLA antigens. Hum Immunol 31:1–6PubMedCrossRefGoogle Scholar
  15. Pohanka E, Cohen N, Colombe BW, Lou C, Salvatierra O Jr, Garovoy MR (1990) Noninherited maternal HLA antigens and protection against sensitization. Lancet 2:1025–1028CrossRefGoogle Scholar
  16. Schäfer AJ, Hasert K, Opelz G (1985) Collaborative transplant study crossmatch and antibody project. Transplant Proc 12:2469–2471Google Scholar
  17. Taube DH, Williams DG, Cameron JS, Welsh KI, Kennedy LA (1984) Renal transplantation after removal and prevention of resynthesis of anti-HLA antibodies. Lancet 1:824–826PubMedCrossRefGoogle Scholar
  18. Thorogood J, Persijn GG, Schreuder GMT, d’Amaro J, Zantvoort FA, van Houwelingen SC, van Rood JJ (1990) The effect of HLA matching on kidney graft survival in separate posttransplantation intervals. Transplantation 50:146–150PubMedCrossRefGoogle Scholar
  19. Van Rood JJ, Claas FHJ (1990) The influence of allogeneic cells on the human T and B cell repertoire. Science 248:1388–1393PubMedCrossRefGoogle Scholar
  20. Zhang L, Li SG, Vandekerckhove BAE, Termijtelen A, van Rood JJ, Claas FHJ (1989) Analysis of cytotoxic T cell precursor frequencies directed agaist individual HLA-A and -B alloantigens. J Immunol Methods 121:39–45PubMedCrossRefGoogle Scholar
  21. Zhang L, van Bree FPMJ, Gijbels Y, van Veen A, van Rood JJ, Claas FHJ (1991 a) Comparison of the humoral and cytotoxic T lymphocyte response to individual HLA class I alloantigens in highly immunized patients. Hum Immunol 30:156–161PubMedCrossRefGoogle Scholar
  22. Zhang L, van Bree FPMJ, van Rood JJ, Claas FHJ (1991b) The influence of breast feeding on the T cell allorepertoire. Transplantation 52:914–916PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • F. H. J. Claas
  • L. Zhang
  • J. J. van Rood

There are no affiliations available

Personalised recommendations