Abstract
Class I major histocompatibility complex (MHC) molecules function as restriction elements and recognition structures for antigen-specific cytotoxic T lymphocytes (Berke 1980; Zinkernagel and Doherty 1974, 1979). In addition, class I MHC molecules participate in interactions with CD 8 that facilitate activation of CD 8 positive T cells (Dembic et al. 1987; Geppert and Lipsky 1986; Fleischer et al. 1986). In each case, it is thought that these interactions are principally involved in generating signals in the cell expressing CD 8, the ligand for class I MHC molecules. Little attention has been given to the possibility that these interactions might also deliver signals to the cell expressing the class I MHC molecule. Recent studies, however, have suggested the possibility that class I MHC molecules expressed by T cells may function as signal transducing elements (Geppert et al. 1988, 1989; Gilliland et al. 1989; Mittler et al. 1990; Gur et al. 1990). The signaling capabilities of class I MHC molecules and the possibility that their ligation provides activation signals to T cells are the focus of this review.
Keywords
- Major Histocompatibility Complex
- Phorbol Myristate Acetate
- Major Histocompatibility Complex Molecule
- Transduce Activation Signal
- Major Histocompatibility Complex Antigen
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Geppert, T.D., Gur, H., Lipsky, P.E. (1993). The Capacity of Class I MHC Molecules To Function as Signal Transduction Elements. In: Solheim, B.G., Ferrone, S., Möller, E. (eds) The HLA System in Clinical Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77506-2_11
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DOI: https://doi.org/10.1007/978-3-642-77506-2_11
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