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The Capacity of Class I MHC Molecules To Function as Signal Transduction Elements

  • T. D. Geppert
  • H. Gur
  • P. E. Lipsky

Abstract

Class I major histocompatibility complex (MHC) molecules function as restriction elements and recognition structures for antigen-specific cytotoxic T lymphocytes (Berke 1980; Zinkernagel and Doherty 1974, 1979). In addition, class I MHC molecules participate in interactions with CD 8 that facilitate activation of CD 8 positive T cells (Dembic et al. 1987; Geppert and Lipsky 1986; Fleischer et al. 1986). In each case, it is thought that these interactions are principally involved in generating signals in the cell expressing CD 8, the ligand for class I MHC molecules. Little attention has been given to the possibility that these interactions might also deliver signals to the cell expressing the class I MHC molecule. Recent studies, however, have suggested the possibility that class I MHC molecules expressed by T cells may function as signal transducing elements (Geppert et al. 1988, 1989; Gilliland et al. 1989; Mittler et al. 1990; Gur et al. 1990). The signaling capabilities of class I MHC molecules and the possibility that their ligation provides activation signals to T cells are the focus of this review.

Keywords

Major Histocompatibility Complex Phorbol Myristate Acetate Major Histocompatibility Complex Molecule Transduce Activation Signal Major Histocompatibility Complex Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • T. D. Geppert
  • H. Gur
  • P. E. Lipsky

There are no affiliations available

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