Typing and Grading of Gastric Dysplasia

  • Y.-C. Zhang


Most pathologists agree that gastric dysplasia, or epithelial dysplasia of the stomach, is an important precancerous change within the stomach. There is, however, much confusion about the nomenclature to be used for such changes. The term “gastric dysplasia” was proposed by a WHO Workshop on Histological Criteria of Precancerous Change of the Stomach in 1978, and it has since been used widely by pathologists [3, 5, 18–21, 27, 32, 38, 45].


Gastric Cancer Early Gastric Cancer Paneth Cell Malignant Change Mucosal Biopsy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Borchard P, Mitteistaedt A, Stux G (1979) Dysplasien im Resektionsmagen und Klassifikationsprobleme verschiedener Dysplasieformen. Verh Dtsch Ges Pathol 63:250–257Google Scholar
  2. 2.
    Bordi C, de Vita O (1984) Pathologia delle precancerosi gastriche e colorektali estratio. Argom Oncol 5:323–331Google Scholar
  3. 3.
    Cuello C, Correa P, Zarama G, Lopez J, Murrar J, Gordillo G (1979) Histopathology of gastric dysplasia. Am J Surg Pathol 3:491–500PubMedCrossRefGoogle Scholar
  4. 4.
    Fukuji S, Kaiyama M, Nozotsuki K (1975) Endoscopic diagnosis of Ila-subtype borderline lesion of the stomach (in Japanese). Stomach Intest 10:1487–1493Google Scholar
  5. 5.
    Grundman E, Schlake W (1979) Histology of possible precancerous stages in stomach. In: Herfarth C, Schlag P (eds) Gastric cancer. Springer, Berlin Heidelberg New York, pp 72–82CrossRefGoogle Scholar
  6. 6.
    Hirota T, Itabashi M, Takizawa C, Kim B (1987) Clinicopathological characteristics of gastric adenoma and its significance as a precancerous lesion (in Japanese). Stomach Intest 22:657–664Google Scholar
  7. 7.
    Japanese Research Society for Gastric Cancer (1985) The general rules for the gastric cancer study, 11th edn. Kanabara, Tokyo, pp 78–100Google Scholar
  8. 8.
    Jarvis L, Whitehead K (1985) Morphometric analysis of gastric dysplasia. J Pathol 147:133–138PubMedCrossRefGoogle Scholar
  9. 9.
    Jass JR (1980) Role of intestinal metaplasia in the histogenesis of gastric carcinoma. J Clin Pathol 33:801–810PubMedCrossRefGoogle Scholar
  10. 10.
    Jass JR (1988) Classification of gastric dysplasia. Histopathology 7:181–193CrossRefGoogle Scholar
  11. 11.
    Kikuchi M, Nakamura K, Akabane H, Shibuya S (1984) Objectification of histologic diagnosis on protruded lesion of atypical epithelium and differentiated carcinoma of stomach: numerical value of structural atypism by morphometric analysis (Engl summary). Stomach Intest 19:1117–1125Google Scholar
  12. 12.
    Li JY, Ho L, Xie YQ, He JS, Jin BQ (1989) Cystic dilatation of the dysplastic gland in gastric mucosa and its relation with gastric cancer (in Chinese). Chinese J Dig 9:230–231Google Scholar
  13. 13.
    Liu SQ, Zhang YC (1987) A newly recognized precancerous lesion of the stomach (Engl abstr). J China Med Univ 16:321–325Google Scholar
  14. 14.
    Liu SQ, Zhang YC (1988) The histopathological classification of globoid dysplasia and its relationship with signet ring cell carcinoma (Engl abstr). J China Med Univ 17:1–6Google Scholar
  15. 15.
    Liu SQ, Zhang YC (1988) The cellular histochemical and immunohistochemical studies on the globoid dysplasia of the human gastric epithelium (Engl abstr). J China Med Univ 17:92–102Google Scholar
  16. 16.
    Liu SQ, Zhang YC (1989) Histopathologic features of globoid dysplasia of the human gastric epithelium (Engl abstr). Chung Hua Chung Liu Tsa Chin 11:37–40Google Scholar
  17. 17.
    Liu SQ, Zhang YC (1989) Characteristics of mucins and CEA in globoid dysplastic cells of human stomach and its relationship with signet ring cell carcinoma (Engl abstr). Zhonghua Zhongliu Zazhi (Chin J Oncol) 11:176–179Google Scholar
  18. 18.
    Ming SC (1984) Precursors of gastric cancer. Praeger, New YorkGoogle Scholar
  19. 19.
    Ming SC, Bajtai A, Correa P, Elster K, Jarvi OH, Munoz N, Nagayo T, Stemmerman GN (1984) Gastric dysplasia. Significance and pathologic criteria. Cancer 54: 1794–1800Google Scholar
  20. 20.
    Morson BC, Sobin LH, Grundmann E, Johansen A, Nagayo T, Serck-Hanssen A (1980) Precancerous conditions and epithelial dysplasia in the stomach. J Clin Pathol 33:711–721PubMedCrossRefGoogle Scholar
  21. 21.
    Nagayo T (1982) Gastric mucosal dysplasia and precancerous lesion (in Japanese). In: Kusama S, Wada T, Miye M (eds) Surgery, vol 28. Kanabara, TokyoGoogle Scholar
  22. 22.
    Nagayo T (1986) Histogenesis and precursors of human gastric cancer. Springer, Berlin Heidelberg New York, pp 126–140CrossRefGoogle Scholar
  23. 23.
    Nagayo T, Suzuki R, Sato T, Suchi T (1987) Retrospective histological studies on biopsied gastric lesions of patients in whom cancer was diagnosed at follow-up examination. Gann 78:997–1005Google Scholar
  24. 24.
    Nakamura K (1982) Structure of the gastric cancer, 1st edn (in Japanese). Igaku Shoin, TokyoGoogle Scholar
  25. 25.
    Nakamura K, Sugano H, Takagi K, Fuchigami A (1966) Histopathological study or early carcinoma of the stomach. Criteria for diagnosis of atypical epithelium. Gann 57:613–620Google Scholar
  26. 26.
    Nakamura K, Sakaguchi H, Enjoji M (1988) Depressed adenoma of the stomach. Cancer 62:2197–2202PubMedCrossRefGoogle Scholar
  27. 27.
    Oehler W (1979) Biological significance of dysplasia of the epithelium and of atrophic gastritis. In: Herfarth CH, Schlag P (eds) Gastric cancer. Springer, Berlin Heidelberg New York, pp 91–104CrossRefGoogle Scholar
  28. 28.
    Sano L (1975) Benign and malignant borderline lesions of the stomach (in Japanese). Stomach Intest 10:1433–1435Google Scholar
  29. 29.
    Sugano H (1972) The pathological morphology of the borderline lesion in digestive tract: atypical epithelium of the stomach (in Japanese). Gan No Rinsho 18:834–842Google Scholar
  30. 30.
    Wang RN, Zhao ML, Su, BH, Ziao SD, Jiang SJ (1988) A model assessment of gastric precancerous lesions by morphometric analysis. Chin Med J [Engl] 101: 403–409Google Scholar
  31. 31.
    Watanabe H (1978) Argentaffin cells in adenoma of the stomach. Cancer 30: 1267–1274CrossRefGoogle Scholar
  32. 32.
    World Health Organization (1972) Report of a WHO meeting on the histological definition of precancerous lesions. WHO, GenevaGoogle Scholar
  33. 33.
    World Health Organization (1987) Establishment of international registration system for gastric dysplasia. WHO CC News Lett 18Google Scholar
  34. 34.
    Wu YQ, Yen RF, Zhang YC (1988) Computer diagnosis of gastric dysplasia and program design (Engl abstr). Zhonghua Zhongliu Zazhi (Chin J Oncol) 10:24–26Google Scholar
  35. 35.
    Xiao SD, Jiang SJ, Wang RN, Hu YB, Liu WZ, Tang XM (1986) N-ethyl-N’-nitro-N-nitrosoguanidine induced gastric carcinoma in wolf-dogs useful model for tracing gastric malignancy transformation. Chin Med J [Engl] 99:903–907Google Scholar
  36. 36.
    Yen RF, Zhang YC, Wu YQ (1987) Morphological measurement for diagnosis of gastric dysplasia (Engl abstr). Zhonghua Zhongliu Zazhi (Chin J Oncol) 9:401–404Google Scholar
  37. 37.
    Yen RF, Zhang YC, Wu YQ (1989) Morphometric indexes and computerized diagnosis of gastric dysplasia. Proc CAMS and PUMC 4:43–47Google Scholar
  38. 38.
    Zhang YC (1983) Epithelial dysplasia of the stomach and its relationship with gastric cancer. 6th Asia Pacific Cancer Conference, SendiGoogle Scholar
  39. 39.
    Zhang YC (1984) Epithelial dysplasia of the stomach and its relationship with gastric cancer. In: Ming SC (ed) Precursors of gastric cancer. Praeger, New York, pp 41–52Google Scholar
  40. 40.
    Zhang YC (1988) Gastric dysplasia. In: Zhang YC (ed) Pathology of the stomach and gastric mucosal biopsy (in Chinese). Liaoning, Shenyang pp 56–74Google Scholar
  41. 41.
    Zhang YC (1989) Pathology of the start point of malignant change from gastric dysplasia (Engl abstr). J Chin Med Univ 18:337–341Google Scholar
  42. 42.
    Zhang YC (1990) Malignant change detected in regenerative type of gastric dysplasia. 79th Meeting of the Japanese Pathologic Association, FukuokaGoogle Scholar
  43. 43.
    Zhang YC, Bai XZ, Zhang WF (1979) Histopathologic study of atypical epithelial proliferation of the gastric mucosa and its follow-up study (Engl abstr). Zhonghua Zhongliu Zazhi (Chin J Oncol) 1:23–28Google Scholar
  44. 44.
    Zhang YC, Sun ZX, Lin HZ, Zhang WF, Bai XW, Aoki K, Kawai K, Sasaki R, Tsychihashi Y, Ito Y, Watanabe N (1987) Spectrum of gastric diseases in North China. In: Wada T, Aoki K, Yachi A (eds) Current status of cancer research in Asia, the Middle East and other countries. UICC-JCA joint conference. University of Nagoya Press, Nagoya, pp 41–49Google Scholar
  45. 45.
    Zhang YC, Zhang PF, Wang MX, Liu SQ (1988) Histopathologic types of gastric dysplasia. Chin J Cancer Res 1:47–52CrossRefGoogle Scholar
  46. 46.
    Zhao ML, Wang RN, Deng YL, Yao JS, Xiao SD, Jiang SJ, Ju HG, Chen DH, Li ZP (1985) A morphometric analysis of gastric precancerous lesions. Quantitative diagnosis of structural atypism in gastric mucosal biopsies. Chin J Dig 5:205–206Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Y.-C. Zhang
    • 1
  1. 1.Cancer Institute of China Medical UniversityHeping District, ShenyangP.R. China

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