Response of Helicobacter pylori-Associated Gastritis to Colloidal Bismuth Subcitrate Versus Ranitidine in Patients with Duodenal Ulcer: A Detailed Histological Assessment

  • J. I. Wyatt
Conference paper


Only a minority of patients treated with monotherapy using colloidal bismuth subcitrate (CBS) will be eradicated of Helicobacter pylori. However, temporary clearance of the bacteria is achieved in a higher proportion of patients and may be related to ulcer healing by CBS. It is not known what factors contribute to this variation in response rate, although previous work by McNulty et al. [1] suggested that elimination of H. pylori might be more successful in patients with initially more severe gastritis.


Duodenal Ulcer Ulcer Healing Bacterial Density Duodenal Ulcer Healing Antral Biopsy 
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    McNulty CAM, Eyre-Brook IA, Uff JS et al. (1989) Triple therapy is not always 95% effective. In: Ruiz Palacios GM (ed) Campylobacter V: proceedings of the 5th international workshop on Campylobacter infectionsGoogle Scholar
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    Wyatt JI, Rathbone BJ, Heatley RV (1986) Local immune response to gastric Campylobacter in non-ulcer dyspepsia. J Clin Pathol 39:863–870PubMedCrossRefGoogle Scholar
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    Hui WM, Lam SK, Ho J et al. (1989) Effect of sucralfate and Cimetidine on duodenal ulcer associated antral gastritis and C pylori. Am J Med 86 (Suppl 64): 60–65PubMedCrossRefGoogle Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • J. I. Wyatt
    • 1
  1. 1.Pathology DepartmentSt. James’s University HospitalLeedsUK

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