Helicobacter pylori and Duodenal Ulcer Relapse: Effect of Bismuth-Free Short-Term Triple Therapy

  • L. G. V. Coelho
  • M. C. F. Passos
  • Y. Chausson
  • M. L. M. Fernandes
  • M. L. G. Nogueira
  • L. P. Castro
Conference paper


Recent studies have demonstrated that the eradication of Helicobacter pylori is associated with a significant reduction in the rate of duodenal ulcer relapse or even the abolition of the disease [1–5]. The best results have been obtained with the use of a combination of bismuth salts with one or two antimicrobial agents [2–5]. However, bismuth salts are not available in many countries and in some their use has been banned because of past reports of toxicity from France and Australia [6–8].


Duodenal Ulcer Pylorus Infection Triple Therapy Breath Test Eradication Rate 
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  1. 1.
    Coghlan JG, Humphreis H, Dooley C et al. (1987) Campylobacter pylori and recurrence of duodenal ulcers—a 12 month follow-up study. Lancet ii: 1109–1111CrossRefGoogle Scholar
  2. 2.
    Marshall BJ, Warren JR, Blincow ED et al. (1988) Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet ii: 1437–1441CrossRefGoogle Scholar
  3. 3.
    Borody TJ, Cole P, Nooman S et al. (1989) Recurrence of duodenal ulcer and Campylobacter pylori infection after eradication. Med J Aust 151:431–435PubMedGoogle Scholar
  4. 4.
    Rauws EAJ, Tytgat GNJ (1990) Cure of duodenal ulcer associated with eradication of Helicobacter pylori. Lancet 335:1233–1235PubMedCrossRefGoogle Scholar
  5. 5.
    George LL, Borody TJ, Andrews A et al. (1990) Cure of duodenal ulcer after eradication of Helicobacter pylori. Med J Aust 153:145–149PubMedGoogle Scholar
  6. 6.
    Burns R, Thomas DW, Barron VJ (1974) Reversible encephalopathy possibly associated with bismuth subgallate ingestion. Br Med J 1:220–223PubMedCrossRefGoogle Scholar
  7. 7.
    Hillemand P, Polliere M, Laquais B et al. (1977) Traitement bismuthique et bismuthemie. Semin Hop 53:1663–1669Google Scholar
  8. 8.
    Monseu G, Struelens M, Roland M (1976) Bismuth encephalopathy. Acta Neurol Belg 76:301–308PubMedGoogle Scholar
  9. 9.
    Zheng ZT, Wang ZY, Chu YA et al. (1985) Double-blind short-term trial of furazolidone in peptic ulcer. Lancet i : 1048Google Scholar
  10. 10.
    Zhao HY, Li G, Guo J et al. (1985) Furazolidone in peptic ulcer. Lancet ii : 276Google Scholar
  11. 11.
    Howden A, Boswell P, Tovey F (1986) In vitro sensitivity of Campylobacter pyloridis to furazolidone. Lancet ii: 1035CrossRefGoogle Scholar
  12. 12.
    Coelho LGV, Queiroz DMM, Barbosa AJA et al. (1989) Furazolidone x Cimetidine in duodenal ulcer C. pylori-positive patients. Gastroenterology 96/5: A91Google Scholar
  13. 13.
    Coelho LGV, Passos MCF, Queiroz DMM et al. (1990) Five day triple therapy and 15-day double therapy on H. pylori eradication. In: Malfertheiner P, Distschneit H (eds) Helicobacter pylori, gastritis and peptic ulcer. Springer, Berlin Heidelberg New York, pp 438–440Google Scholar
  14. 14.
    Coelho LGV, Passos MCF, Chausson Y, Castro LP (1991) Five day bismuth-free triple therapy for the eradication of Helicobacter pylori and reduction of duodenal ulcer relapse. Am J Gastroenterol 86(8): 971–975PubMedGoogle Scholar
  15. 15.
    Coelho LGV, Chausson Y, Passos MCF et al. (1990) Test repiratoire ā l’urēe marquēe au carbone-14 pour le diagnostic de la colonisation gastrique par le Helicobacter pylori. Gastroenterol Clin Biol 14:801–805PubMedGoogle Scholar
  16. 16.
    Freedberg AS, Barron LE (1940) The presence of spirochetes in human gastric mucosa. Am J Dig Dis 7:443–445CrossRefGoogle Scholar
  17. 17.
    Graham DY, Lew GM, Michaletz PA (1989) Randomized trial of the effect of eradication of C pylori on ulcer healing and relapse. Gastroenterology 96 [Suppl]:A181Google Scholar
  18. 18.
    Rauws EAJ, Langenberg W, Houthoff HJ et al. (1989) Campylobacter pyloridis-associated chronic active antral gastritis. Gastroenterology 94:33–40Google Scholar
  19. 19.
    Börsch G, Mai U, Opjerkuch W (1989) Short and medium-term results of oral triple therapy to eradicate C. pylori. Gastroenterology 96 : A53Google Scholar
  20. 20.
    Hirschl AM, Hentschel E, Schütze K et al. (1988) The efficacy of antimicrobial treatment in Campylobacter pylori — associated gastritis and duodenal ulcer. Scand J Gastroenterol 23 [Suppl 142]: 76–87CrossRefGoogle Scholar
  21. 21.
    Playford RJ, Matthews CH, Campbell MJ et al. (1990) Bismuth induced encephalopathy caused by tri potassium dicitrato bismuthate in a patient with chronic renal failure. Gut 31:359–360PubMedCrossRefGoogle Scholar
  22. 22.
    Glupczynski Y, Bourdeaux L, Verhas M, Balegamire B, Devos D, Devrecker T (1989) Epidemiology of Campylobacter pylori infection in Zaire. Klin Wochenschr 67 [Suppl XVIII] : 23Google Scholar
  23. 23.
    Perez-Perez GI, Taylor DN, Bodhidatta L et al. (1990) Seroprevalence of Helicobacter infections in Thailand. J Infect Dis 161:1237–1241PubMedCrossRefGoogle Scholar
  24. 24.
    Levi S, Beardshall K, Swift I et al. (1989) Antral Helicobacter pylori, hypergastrinaemia, and duodenal ulcers: effect of eradicating the organism. Br Med J 299:1504–1505CrossRefGoogle Scholar
  25. 25.
    Bayerdörffer E, Ottenjann R (1988) The role of antibiotics in Campylobacter pylori associated peptic ulcer disease. Scand J Gastroenterol 23 [Suppl 142]: 93–100CrossRefGoogle Scholar
  26. 26.
    Graham DY, Klein PD, Opekum AR et al. (1989) In vivo susceptibility of Campylobacter pylori. Am J Gastroenterol 84:233–238PubMedGoogle Scholar
  27. 27.
    Tytgat GNJ, Axon ATR, Dixon MF, Graham DY, Lee A, Marshall BJ (1990) Helicobacter pylori : causal agent in peptic ulcer disease? In: Working party reports. World congress of gastreonterology, Sydney. Blackwell, Oxford, p 36–45Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • L. G. V. Coelho
    • 1
  • M. C. F. Passos
    • 1
  • Y. Chausson
    • 2
  • M. L. M. Fernandes
    • 3
  • M. L. G. Nogueira
    • 3
  • L. P. Castro
    • 1
  1. 1.Gastroenterology, Nutrition, and Digestive Surgery UnitUniversity Hospital, Federal University of Minas GeraisBelo HorizonteBrazil
  2. 2.National Committee of Nuclear Energy (CDTN)Pampulha, Belo HorizonteBrazil
  3. 3.Department of StatisticsICEX, Federal University of Minas GeraisPampulha, Belo HorizonteBrazil

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