Histological and Serological Examination of Helicobacter pylori in Estonian Children with Abdominal Complaints
Chronic gastritis has been found to be common in Estonian children with abdominal complaints (61 %), and in 85% of cases it was caused by Helicobacter pylori (HP) . Infected adult patients elicit a signicicant circulating antibody response against antigens of HP . The systemic antibody response to HP in children has not been studied to the same extent. Some authors have found that HP antibody levels in children mirror investigations in adult patients [3, 4], others claim that HP antibodies are not a common finding in children [5, 6]. The aim of our study was to determine HP-IgG antibody frequency in children with histologically proven but slight gastritis and to examine the correlation between HP-IgG antibodies and HP colonisation intensity in the antral and body mucosa. Glycin extract antigen and the enzyme-linked immunosorbent assay (ELISA) method were used in parallel in two laboratories (in Tartu and in Lund) on the same children’s sera.
KeywordsChronic Gastritis Spearman Rank Correlation Test Abdominal Complaint Antral Mucosa Serological Examination
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