A Role for Helicobacter pylori in Gastric Carcinoma?

  • R. J. L. F. Loffeld
  • I. Willems
  • J. W. Arends
Conference paper


The exact aetiology of gastric carcinoma is unknown. Many impetuses are known or suspected to play a role in the pathogenesis of gastric cancer. It is generally accepted in the literature that induction of gastritis is the initial event in the pathogenesis. If the inflammation persists for many years, this will eventually lead to the development of intestinal metaplasia and atrophia. Together with other impetuses, such as, for instance, toxic substances, this can finally lead to the development of gastric cancer. Of course this sequence is much more complicated and not unraveled to its full extent.


Gastric Cancer Gastric Carcinoma Intestinal Metaplasia Bacterial Load Healthy Blood Donor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Krienitz W (1906) Ueber das Autreten von Mageninhalt bei Carcinoma Ventriculi. Dtsch Med Wochenschr 22:872CrossRefGoogle Scholar
  2. 2.
    Correa P, Ruiz B (1989) Campylobacter pylori and gastric cancer. In: Rathbone BJ, Heatly RV (eds) Campylobacter pylori and gastroduodenal disease, Blackwell, LondonGoogle Scholar
  3. 3.
    Loffeld RJLF, Potters HVPJ, Arends JW, Stobberingh E, Flendrig JA, van Spreeuwel JP (1988) Campylobacter associated gastritis in patients with non-ulcer dyspepsia. J Clin Pathol 41:85–88PubMedCrossRefGoogle Scholar
  4. 4.
    Loffeld RJLF, Stobberingh E, Flendring JA, van Spreeuwel JP, Arends JW (1989) Diagnostic value of an immunoassay to detect anti Campylobacter pylori antibodies in non-ulcer dyspepsia. Lancet i:1182–1185CrossRefGoogle Scholar
  5. 5.
    Loffeld RJLF, Stobberingh E, Flendrig JA, Arends JW (1990) The prevalence of anti Campylobacter pylori antibodies in patients and healthy blood donors. J Med Microbiol 32:105–109PubMedCrossRefGoogle Scholar
  6. 6.
    Lingwood CA, Pellizzari A, Law H, Sherman P, Drumm B (1989) Gastric glycerolipid as a receptor for Campylobacter pylori. Lancet ii:238–241CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • R. J. L. F. Loffeld
    • 1
  • I. Willems
    • 2
  • J. W. Arends
    • 2
  1. 1.Department of Internal MedicineUniversity Hospital MaastrichtMaastrichtThe Netherlands
  2. 2.Department of PathologyUniversity Hospital MaastrichtMaastrichtThe Netherlands

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