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Helicobacter pylori and Gastroduodenal Pathology pp 187–193Cite as

Cytokines and Mucosal Immune Responses to Helicobacter pylori

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Abstract

Cytokines are well recognised as being important regulators of inflammatory responses [1]. They are synthesised by several different cell types, and individual cytokines have multiple overlapping regulatory immune functions [1] as well as affecting physiological responses [2]. Cytokines are generally short acting and produced locally. The role of cytokines in regulating human intestinal mucosal responses has not been studied in detail, and the cytokine responses of the gastrointestinal mucosa to bacterial colonisation are unclear. Recent studies in animal models suggest that cytokine production at mucosal sites in response to bacterial or endotoxin administration is distinct from systemic events [3, 4]. A knowledge of cytokine production at mucosal sites is therefore important to our understanding of host-bacterial interactions and the immunopathology of chronic infections at mucosal surfaces.

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Author information

Authors and Affiliations

  1. Department of Medicine, St. James’s University Hospital, Leeds, LS9 7TF, UK

    J. E. Crabtree, T. M. Shallcross & R. V. Heatley

  2. Department of Pathology, St. James’s University Hospital, Leeds, LS9 7TF, UK

    J. I. Wyatt

Authors
  1. J. E. Crabtree
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  2. T. M. Shallcross
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  3. R. V. Heatley
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  4. J. I. Wyatt
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Editor information

Editors and Affiliations

  1. Hospital de la Princesa, Autonoma University of Madrid, Diego de Leon, 62, 28006, Madrid, Spain

    José M. Pajares M.D., Ph.D. (Professor of Medicine, Head of Department of Gastroenterology) (Professor of Medicine, Head of Department of Gastroenterology)

  2. Free University of Amsterdam, De Boelelaam 1117, 1081 HV, Amsterdam, The Netherlands

    A. Salvador Peña M.D., Ph.D. (Professor of Gastrointestinal Immunology) (Professor of Gastrointestinal Immunology)

  3. Abt. Innere Medizin II, Universitäts Klinik Ulm, Robert-Koch-Str. 8, W-7900, Ulm, Germany

    Peter Malfertheiner Prof. Dr. med.

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© 1993 Springer-Verlag Berlin Heidelberg

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Crabtree, J.E., Shallcross, T.M., Heatley, R.V., Wyatt, J.I. (1993). Cytokines and Mucosal Immune Responses to Helicobacter pylori . In: Pajares, J.M., Peña, A.S., Malfertheiner, P. (eds) Helicobacter pylori and Gastroduodenal Pathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77486-7_32

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  • DOI: https://doi.org/10.1007/978-3-642-77486-7_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77488-1

  • Online ISBN: 978-3-642-77486-7

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