Abstract
Certain Helicobacter pylori (HP) strains are capable of inducing a cytopathic effect in mammalian cells in vitro consisting in the formation of intracytoplasmic vacuoles [1, 2]. In vitro cells exposed to broth culture filtrate (BCF) of vacuolating HP (VHP) strains die more rapidly than do cells exposed to BCF of non-VHP ones and to uninoculated broth. In addition, VHP causes a strong reduction of the proliferation index of Epstein-Bass Virus (EBV) -transformed B lymphocytes [2].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Leunk RD, Johnson PT, David BC, Kraft WG, Morgan DR (1988) Cytotoxic activity in broth–culture filtrates of Campylobacter pylori. J Med Microbiol 26:93–99
Figura N, Bugnoli M, Cusi MG, Pucci AM, Lusini P, Quaranta S, Barberi A, Rossolini A, Di Tommaso AL, De Magistris T, Rappuoli R, Marri L, Musmanno RA, Russi M, Guarna M, Losi M (1990) Pathogenic mechanisms of Helicobacter pylori: production of cytotoxin. In: Malfertheiner P, Ditschuneit H (Eds) Helicobacter pylori, gastritis and peptic ulcer. Springer, Berlin Heidelberg New York, pp 86–95
Cover TL, Dooley CP, Blaser MJ (1990) Characterization of and human serologic response to proteins in Helicobacter pylori broth culture supernatants with vacuolizing cytotoxin activity. Infect Immun 58:603–610
Figura N, Guglielmetti P, Rossolini A, Cusi MG, Musmanno RA, Russi M, Ibba L, Pucci AM, Losi M, Quaranta S (1989) Does the production of cytotoxin by Campylobacter pylori play a pathological role in the development of peptic ulcer? In: Mégraud F, Lamouliatte H (Eds) Gastroduodenal pathology and Campylobacter Pylori. Excerpta Medica, Amsterdam, pp 385–389
Figura N, Guglielmetti P, Rossolini A, Barberi A, Cusi G, Musmanno RA, Russi M, Quaranta S (1989) Cytotoxin production by Campylobacter pylori strains isolated from patients with peptic ulcers and from patients with chronic gastritis only. J Clin Microbiol 27:225–226
Xu JK, Goodwin CS, Cooper M, Robinson J (1990) Intracellular vacuolization caused by the urease of Helicobacter pylori. J Infect Dis 161:1302–1304
Leunk RD, Ferguson MA, Williams EA, Eaton KA (1990) Adherence and production of cytotoxin by urease-producing and urease-deficient strains of Helicobacter pylori. Rev Esp Enferm Dig 78 (Suppl 1):54
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Figura, N. et al. (1993). Antibodies to Vacuolating Toxin of Helicobacter pylori in Dyspeptic Patients. In: Pajares, J.M., Peña, A.S., Malfertheiner, P. (eds) Helicobacter pylori and Gastroduodenal Pathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77486-7_31
Download citation
DOI: https://doi.org/10.1007/978-3-642-77486-7_31
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-77488-1
Online ISBN: 978-3-642-77486-7
eBook Packages: Springer Book Archive