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Local and Systemic Antibody Responses During Helicobacter pylori Infections

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Helicobacter pylori and Gastroduodenal Pathology

Abstract

The majority of patients with a Helicobacter pylori infection mount a systemic antibody response which is easily detectable by serological assays such as the enzyme-linked immunosorbent assay (ELISA) [1]. Positive results in bacterial agglutination and complement fixation tests [2] suggest that these antibodies possess some anti-bacterial activity. However, the infection persists suggesting an underlying ineffectiveness in the ability of the systemic antibody response to eradicate the infection.

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References

  1. Newell DG, Rathbone BJ (1989) The serodiagnosis of Campylobacter pylori infection—a review. Serodiagn Immunother 3:1–6

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  2. Jones DM, Lessels AM, Eldridge J (1984) Campylobacter-like organisms on the gastric mucosa: culture, histology and serological studies. J Clin Pathol 37:1002–1006

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  3. Stacey AR, Hawtin PR, Newell DG (1990) Local immune responses to Helicobacter pylori infections. In: Malfertheiner P, Ditschuneit H (eds) Helicobacter pylori, gastritis and peptic ulcer. Springer, Berlin Heidelberg New York, pp 162–166

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© 1993 Springer-Verlag Berlin Heidelberg

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Stacey, A.R., Hawtin, P.R., Newell, D.G. (1993). Local and Systemic Antibody Responses During Helicobacter pylori Infections. In: Pajares, J.M., Peña, A.S., Malfertheiner, P. (eds) Helicobacter pylori and Gastroduodenal Pathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77486-7_28

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  • DOI: https://doi.org/10.1007/978-3-642-77486-7_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77488-1

  • Online ISBN: 978-3-642-77486-7

  • eBook Packages: Springer Book Archive

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