Bacteria and Gastrin Release

  • J. Calam
  • R. A. Goodlad
  • C. Y. Lee
  • B. Ratcliffe
  • M. E. Coates
  • G. W. H. Stamp
  • N. A. Wright
Conference paper

Abstract

Expansion of Scientific knowledge and techniques has put pressure on researchers to narrow their interest to quite specific topics. Apart from the clinical benefits that it is bringing, work on Helicobacter pylori is refreshing because it forces us to think laterally and consider interactions between changes observed in different disciplines such as biochemistry, physiology, immunology and bacteriology.

Keywords

Acidity Interferon Histamine Cane Thymidine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Blair AJI, Feldman M, Barnett C, Walsh JH, Richardson T (1987) Detailed comparison of basal and food-stimulated gastric acid secretion rates and serum gastrin concentrations in duodenal ulcer patients and normal subjects. J Clin Invest 79:582–587PubMedCrossRefGoogle Scholar
  2. 2.
    Borch K, Renvall H, Leidberg GV (1985) Gastric endocrine cell hyperplasia and carcinoid tumours in pernicious anaemia. Gastroenterology 88:638–642PubMedGoogle Scholar
  3. 3.
    Brand SJ, Stone D (1988) Reciprocal regulation of antral gastrin and somatostatin gene expression by Omeprazole-induced achlorhydria. J Clin Invest 82:1059–1066PubMedCrossRefGoogle Scholar
  4. 4.
    Brittain RT, Jack D, Reeves JJ, Stables R (1985) Pharmacological basis for the induction of gastric carcinoid tumours in the rat by loxtidine, an unsurmountable histamine H2-receptor blocking drug. Br J Pharmacol 85:843–847PubMedGoogle Scholar
  5. 5.
    Calam J, Tracy HJ (1980) Pyloric reflux and gastrin cell hyperfunction. Lancet 2:918PubMedCrossRefGoogle Scholar
  6. 6.
    Calam J, Goodlad RA, Lee CY, Ratclifle B, Coates ME, Stamp GWH, Wright NA (1991) Achlorhydria, hypergastrinaemia : the role of bacteria. Clin Sci 80:281–284PubMedGoogle Scholar
  7. 7.
    Cave DR, Vargas M (1989) Effect of a Campylobacter pylori protein on acid secretion by parietal cells. Lancet 2:187–189PubMedCrossRefGoogle Scholar
  8. 8.
    Chiltajallu RS, Dorian CA, McColl KEL (1990) Is Helicobacter pylori-associated hypergastrinaemia due to the bacterium’s urease or the antral gastritis? Gut 31 : A1175Google Scholar
  9. 9.
    Cooper RG, Dockray GJ, Calam J, Walker RJ (1985) Acid and gastrin responses during intragastric titration in normal subjects and duodenal ulcer patients with G-cell hyperfunction. Gut 26:232–236PubMedCrossRefGoogle Scholar
  10. 10.
    Crabtree JE, Shallcross TM, Wyatt JI, Heatley RV (1990) Tumour necrosis factor alpha secretion by Helicobacter pylori colonised gastric mucosa. Gut 31 :A600–601CrossRefGoogle Scholar
  11. 11.
    Del Pozo V, De Andres B, Martin E, Maruri N, Zubeldia JM, Palomino P, Lahoz C (1990) Murine eosinophils and IL-1: aIL-1 mRNA detected by in situ hybridisation. J Immunol 144:3117–3122PubMedGoogle Scholar
  12. 12.
    Drasar BS, Shiner J, McLeod GM (1969) Studies of the flora of the gastrointestinal tract in healthy and achlorhydric persons. Gastroenterology 56:71–79PubMedGoogle Scholar
  13. 13.
    El Nujumi AM, Dorain CA, Chittajallu RS, Neithercut WD, McColl KEL (1991) Effect of inhibition of H. pylori urease activity by acetohydroxamic acid on serum gastrin in duodenal ulcer subjects. Gut 32:866–870PubMedCrossRefGoogle Scholar
  14. 14.
    Goodlad RA, Ratclifle BR, Fordham JP, Wright NA (1989) Does dietary fiber stimulate epithelial cell proliferation in germ-free rats? Gut 30:820–825PubMedCrossRefGoogle Scholar
  15. 15.
    Graham DY, Opekun A, Lew GM, Evans DJJ, Klein PD, Evans DG (1990) Ablation of exaggerated meal-stimulated gastrin release in duodenal ulcer patients after clearance of Helicobacter (Campylobacter) pylori infection. Am J Gastroenterol 85:394–398PubMedGoogle Scholar
  16. 16.
    Johnson LR (1976) The trophic effect of gastrointestinal hormones. Gastroenterology 70:278–283PubMedGoogle Scholar
  17. 17.
    Kekki M, Sipponen P, Siurula M (1984) Progression of antral and body gastritis in active and healed duodenal ulcer and-duodenitis. Scand J Gastroenterol 19:382–388PubMedGoogle Scholar
  18. 18.
    Kelly SM, Crampton J, Hunter JO (1990) Helicobacter pylori increases the pH of the gastric mucosa in vivo. Gut 31 : A1177–1178Google Scholar
  19. 19.
    Lam Sk (1984) Pathogenesis and pathophysiology of duodenal ulcer. Clin Gastroenterol 13:447–472PubMedGoogle Scholar
  20. 20.
    Lanzon-Miller S, Pounder REMR, Chronos NAF, Ball S, Mercieca JE, Plausson M, Ceder-berg C (1987) Twenty-four-hour intragastric acidity and plasma gastrin concentration in healthy subjects and patients with duodenal or gastric ulcer, or pernicious anaemia. Aliment Pharmacol Ther 1:225–237PubMedCrossRefGoogle Scholar
  21. 21.
    Lanzon-Miller S, Pounder RE, Hamilton MR, Ball S, Chronos NAF, Raymond F, Olaus-son M, Cederberg C (1987) Twenty-four hour intragastric acidity and plasma gastrin concentration before and during treatment with either ranitidine on omeprazole. Aliment Pharmacol Ther 1:239–251PubMedCrossRefGoogle Scholar
  22. 22.
    Larsson H, Carlsson E, Mattsson H, Lundell L, Sundler F, Sundell G, Wallmark B, Watana-be T, Hakanson R (1986) Plasma gastrin and gastric enterochromaffin like cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomised rats. Gastroenterology 90:391–399PubMedGoogle Scholar
  23. 23.
    Levi S, Beardshall K, Haddad G, Playford R, Ghosh P, Calam J (1989) Campylobacter and duodenal ulcers: the gastrin link. Lancet 1:1167–1168PubMedCrossRefGoogle Scholar
  24. 24.
    Levi S, Beardshall K, Swift I, Foulks W, Playford R, Ghosh P, Calam J (1989) Antral Campylobacter pylori, hypergastrinaemia, and duodenal ulcers: Effect of eradicating the organism. Br Med J 299:1504–1505CrossRefGoogle Scholar
  25. 25.
    Lind T, Cederberg C, Forssell H, Olausson M, Olbe L (1988) Relationship between reduction of gastric acid secretion and plasma gastrin concentration during omeprazole treatment. Scand J Gastroenterol 23:1259PubMedCrossRefGoogle Scholar
  26. 26.
    Mai UEH, Perez-Perez Gl, Wahl LM, Wahl SM, laser MJ, Smith PD (1990) Inflammatory and cytoprotective responses by human monocytes are induced by Helicobacter pylori: possible role in the pathogenesis of type B gastritis (abstract). Gastroenterology 981 : A662Google Scholar
  27. 27.
    McColl KE, Fullarton GM, ElNujumi AM, Macdonald AM, Brown IL (1989) Lowered acidity gastrin and gastric acidity after eradication of Campylobacter pylori in duodenal ulcer. Lancet 2:499–500PubMedCrossRefGoogle Scholar
  28. 28.
    McColl KEL, Fullarton GM, El Nujumi AM, Macdonald AMI, Dahil S, Hilditch TE (1990) Serum gastrin and gastric acid status one and seven months after eradication of Helicobacter pylori in duodenal ulcer patients. Gut 31 :A601Google Scholar
  29. 29.
    Moss S, Calam J (1990) Pathophysiology of gastrointestinal hormones. Curr Opin Gastroenterol 6:877–881CrossRefGoogle Scholar
  30. 30.
    Muscroft TJ, Burdon DW, Youngs D, Keighley MRB (1981) Cimetidine is unlikely to increase formation of intragastric N-nitroso-compounds in patients taking normal diet. Lancet 1:408–410PubMedCrossRefGoogle Scholar
  31. 31.
    Peters M, Feldman M, Walsh J, Richardson C, (1983) Effect of gastric alkalinization on serum gastrin concentrations in humans. Gastroenterology 85:35–39PubMedGoogle Scholar
  32. 32.
    Richards AT, Hinder RA, Harrison AC (1987) Gastric carcinoid tumours associated with hypergastrinaemia and pernicious anaemia — regression of tumours by antrectomy. S Afr Med J 72:51–54PubMedGoogle Scholar
  33. 33.
    Ryberg B, Mattsson H, Carlsson E (1988) Effects of Omeprazole and Ranitidine on gastric acid secretion, blood gastrin levels and [3H] thymidine incorporation in the oxyntic mucosa from dogs and rats. Digestion 39:91–99PubMedCrossRefGoogle Scholar
  34. 34.
    Sjogren RW, Sherman PM, Boedeker EC (1989) Altered intestinal motility precedes diarrhoea during Escherichia coli infection. Am J Physiol 257:G725–G731PubMedGoogle Scholar
  35. 35.
    Teichman RK, Pratschke E, Grab J, Hammer C, Brendel W (1986) Gastrin release by inter-leukin-2 and gamma-interferon in vitro. Can J Physiol Pharmacol (suppl) 64:62Google Scholar
  36. 36.
    Walsh JH (1987) Gastrointestinal hormones. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven, New York, pp 181–254Google Scholar
  37. 37.
    Walsh JH, Grossman M (1975) Medical progress: gastrin. N Engl J Med 292:1324–1332PubMedCrossRefGoogle Scholar
  38. 38.
    Wyatt JI, Rathbone BJ, Green DM, Primrose J (1989) Raised fasting serum gastrin in chronic gastritis is independent of Campylobacter pylori status and duodenal ulceration. Gut 30 :A1483Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • J. Calam
    • 1
  • R. A. Goodlad
    • 2
  • C. Y. Lee
    • 2
  • B. Ratcliffe
    • 3
  • M. E. Coates
    • 4
  • G. W. H. Stamp
    • 2
  • N. A. Wright
    • 2
  1. 1.Department of MedicineRoyal Postgraduate Medical School, Hammersmith HospitalLondonUK
  2. 2.Department of HistopathologyImperial Cancer Research Fund, Lincoln’s Inn FieldsLondonUK
  3. 3.Department of Chemistry and Life SciencesThe Polytechnic of North LondonLondonUK
  4. 4.Department of BiochemistryUniversity of SurreyGuildfordUK

Personalised recommendations