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Bacteria and Gastrin Release

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Helicobacter pylori and Gastroduodenal Pathology

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Abstract

Expansion of Scientific knowledge and techniques has put pressure on researchers to narrow their interest to quite specific topics. Apart from the clinical benefits that it is bringing, work on Helicobacter pylori is refreshing because it forces us to think laterally and consider interactions between changes observed in different disciplines such as biochemistry, physiology, immunology and bacteriology.

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References

  1. Blair AJI, Feldman M, Barnett C, Walsh JH, Richardson T (1987) Detailed comparison of basal and food-stimulated gastric acid secretion rates and serum gastrin concentrations in duodenal ulcer patients and normal subjects. J Clin Invest 79:582–587

    Article  PubMed  Google Scholar 

  2. Borch K, Renvall H, Leidberg GV (1985) Gastric endocrine cell hyperplasia and carcinoid tumours in pernicious anaemia. Gastroenterology 88:638–642

    PubMed  CAS  Google Scholar 

  3. Brand SJ, Stone D (1988) Reciprocal regulation of antral gastrin and somatostatin gene expression by Omeprazole-induced achlorhydria. J Clin Invest 82:1059–1066

    Article  PubMed  CAS  Google Scholar 

  4. Brittain RT, Jack D, Reeves JJ, Stables R (1985) Pharmacological basis for the induction of gastric carcinoid tumours in the rat by loxtidine, an unsurmountable histamine H2-receptor blocking drug. Br J Pharmacol 85:843–847

    PubMed  CAS  Google Scholar 

  5. Calam J, Tracy HJ (1980) Pyloric reflux and gastrin cell hyperfunction. Lancet 2:918

    Article  PubMed  CAS  Google Scholar 

  6. Calam J, Goodlad RA, Lee CY, Ratclifle B, Coates ME, Stamp GWH, Wright NA (1991) Achlorhydria, hypergastrinaemia : the role of bacteria. Clin Sci 80:281–284

    PubMed  CAS  Google Scholar 

  7. Cave DR, Vargas M (1989) Effect of a Campylobacter pylori protein on acid secretion by parietal cells. Lancet 2:187–189

    Article  PubMed  CAS  Google Scholar 

  8. Chiltajallu RS, Dorian CA, McColl KEL (1990) Is Helicobacter pylori-associated hypergastrinaemia due to the bacterium’s urease or the antral gastritis? Gut 31 : A1175

    Google Scholar 

  9. Cooper RG, Dockray GJ, Calam J, Walker RJ (1985) Acid and gastrin responses during intragastric titration in normal subjects and duodenal ulcer patients with G-cell hyperfunction. Gut 26:232–236

    Article  PubMed  CAS  Google Scholar 

  10. Crabtree JE, Shallcross TM, Wyatt JI, Heatley RV (1990) Tumour necrosis factor alpha secretion by Helicobacter pylori colonised gastric mucosa. Gut 31 :A600–601

    Article  Google Scholar 

  11. Del Pozo V, De Andres B, Martin E, Maruri N, Zubeldia JM, Palomino P, Lahoz C (1990) Murine eosinophils and IL-1: aIL-1 mRNA detected by in situ hybridisation. J Immunol 144:3117–3122

    PubMed  Google Scholar 

  12. Drasar BS, Shiner J, McLeod GM (1969) Studies of the flora of the gastrointestinal tract in healthy and achlorhydric persons. Gastroenterology 56:71–79

    PubMed  CAS  Google Scholar 

  13. El Nujumi AM, Dorain CA, Chittajallu RS, Neithercut WD, McColl KEL (1991) Effect of inhibition of H. pylori urease activity by acetohydroxamic acid on serum gastrin in duodenal ulcer subjects. Gut 32:866–870

    Article  PubMed  CAS  Google Scholar 

  14. Goodlad RA, Ratclifle BR, Fordham JP, Wright NA (1989) Does dietary fiber stimulate epithelial cell proliferation in germ-free rats? Gut 30:820–825

    Article  PubMed  CAS  Google Scholar 

  15. Graham DY, Opekun A, Lew GM, Evans DJJ, Klein PD, Evans DG (1990) Ablation of exaggerated meal-stimulated gastrin release in duodenal ulcer patients after clearance of Helicobacter (Campylobacter) pylori infection. Am J Gastroenterol 85:394–398

    PubMed  CAS  Google Scholar 

  16. Johnson LR (1976) The trophic effect of gastrointestinal hormones. Gastroenterology 70:278–283

    PubMed  CAS  Google Scholar 

  17. Kekki M, Sipponen P, Siurula M (1984) Progression of antral and body gastritis in active and healed duodenal ulcer and-duodenitis. Scand J Gastroenterol 19:382–388

    PubMed  CAS  Google Scholar 

  18. Kelly SM, Crampton J, Hunter JO (1990) Helicobacter pylori increases the pH of the gastric mucosa in vivo. Gut 31 : A1177–1178

    Google Scholar 

  19. Lam Sk (1984) Pathogenesis and pathophysiology of duodenal ulcer. Clin Gastroenterol 13:447–472

    PubMed  CAS  Google Scholar 

  20. Lanzon-Miller S, Pounder REMR, Chronos NAF, Ball S, Mercieca JE, Plausson M, Ceder-berg C (1987) Twenty-four-hour intragastric acidity and plasma gastrin concentration in healthy subjects and patients with duodenal or gastric ulcer, or pernicious anaemia. Aliment Pharmacol Ther 1:225–237

    Article  PubMed  CAS  Google Scholar 

  21. Lanzon-Miller S, Pounder RE, Hamilton MR, Ball S, Chronos NAF, Raymond F, Olaus-son M, Cederberg C (1987) Twenty-four hour intragastric acidity and plasma gastrin concentration before and during treatment with either ranitidine on omeprazole. Aliment Pharmacol Ther 1:239–251

    Article  PubMed  CAS  Google Scholar 

  22. Larsson H, Carlsson E, Mattsson H, Lundell L, Sundler F, Sundell G, Wallmark B, Watana-be T, Hakanson R (1986) Plasma gastrin and gastric enterochromaffin like cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomised rats. Gastroenterology 90:391–399

    PubMed  CAS  Google Scholar 

  23. Levi S, Beardshall K, Haddad G, Playford R, Ghosh P, Calam J (1989) Campylobacter and duodenal ulcers: the gastrin link. Lancet 1:1167–1168

    Article  PubMed  CAS  Google Scholar 

  24. Levi S, Beardshall K, Swift I, Foulks W, Playford R, Ghosh P, Calam J (1989) Antral Campylobacter pylori, hypergastrinaemia, and duodenal ulcers: Effect of eradicating the organism. Br Med J 299:1504–1505

    Article  CAS  Google Scholar 

  25. Lind T, Cederberg C, Forssell H, Olausson M, Olbe L (1988) Relationship between reduction of gastric acid secretion and plasma gastrin concentration during omeprazole treatment. Scand J Gastroenterol 23:1259

    Article  PubMed  CAS  Google Scholar 

  26. Mai UEH, Perez-Perez Gl, Wahl LM, Wahl SM, laser MJ, Smith PD (1990) Inflammatory and cytoprotective responses by human monocytes are induced by Helicobacter pylori: possible role in the pathogenesis of type B gastritis (abstract). Gastroenterology 981 : A662

    Google Scholar 

  27. McColl KE, Fullarton GM, ElNujumi AM, Macdonald AM, Brown IL (1989) Lowered acidity gastrin and gastric acidity after eradication of Campylobacter pylori in duodenal ulcer. Lancet 2:499–500

    Article  PubMed  CAS  Google Scholar 

  28. McColl KEL, Fullarton GM, El Nujumi AM, Macdonald AMI, Dahil S, Hilditch TE (1990) Serum gastrin and gastric acid status one and seven months after eradication of Helicobacter pylori in duodenal ulcer patients. Gut 31 :A601

    Google Scholar 

  29. Moss S, Calam J (1990) Pathophysiology of gastrointestinal hormones. Curr Opin Gastroenterol 6:877–881

    Article  Google Scholar 

  30. Muscroft TJ, Burdon DW, Youngs D, Keighley MRB (1981) Cimetidine is unlikely to increase formation of intragastric N-nitroso-compounds in patients taking normal diet. Lancet 1:408–410

    Article  PubMed  CAS  Google Scholar 

  31. Peters M, Feldman M, Walsh J, Richardson C, (1983) Effect of gastric alkalinization on serum gastrin concentrations in humans. Gastroenterology 85:35–39

    PubMed  CAS  Google Scholar 

  32. Richards AT, Hinder RA, Harrison AC (1987) Gastric carcinoid tumours associated with hypergastrinaemia and pernicious anaemia — regression of tumours by antrectomy. S Afr Med J 72:51–54

    PubMed  CAS  Google Scholar 

  33. Ryberg B, Mattsson H, Carlsson E (1988) Effects of Omeprazole and Ranitidine on gastric acid secretion, blood gastrin levels and [3H] thymidine incorporation in the oxyntic mucosa from dogs and rats. Digestion 39:91–99

    Article  PubMed  Google Scholar 

  34. Sjogren RW, Sherman PM, Boedeker EC (1989) Altered intestinal motility precedes diarrhoea during Escherichia coli infection. Am J Physiol 257:G725–G731

    PubMed  CAS  Google Scholar 

  35. Teichman RK, Pratschke E, Grab J, Hammer C, Brendel W (1986) Gastrin release by inter-leukin-2 and gamma-interferon in vitro. Can J Physiol Pharmacol (suppl) 64:62

    Google Scholar 

  36. Walsh JH (1987) Gastrointestinal hormones. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven, New York, pp 181–254

    Google Scholar 

  37. Walsh JH, Grossman M (1975) Medical progress: gastrin. N Engl J Med 292:1324–1332

    Article  PubMed  CAS  Google Scholar 

  38. Wyatt JI, Rathbone BJ, Green DM, Primrose J (1989) Raised fasting serum gastrin in chronic gastritis is independent of Campylobacter pylori status and duodenal ulceration. Gut 30 :A1483

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, London, W12 ONN, UK

    J. Calam

  2. Department of Histopathology, Imperial Cancer Research Fund, Lincoln’s Inn Fields, London, WC2A 3PN, UK

    R. A. Goodlad, C. Y. Lee, G. W. H. Stamp & N. A. Wright

  3. Department of Chemistry and Life Sciences, The Polytechnic of North London, Holloway Road, London, W7 8DB, UK

    B. Ratcliffe

  4. Department of Biochemistry, University of Surrey, Guildford, Surrey, GU2 5XH, UK

    M. E. Coates

Authors
  1. J. Calam
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  2. R. A. Goodlad
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  3. C. Y. Lee
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  4. B. Ratcliffe
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  5. M. E. Coates
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  6. G. W. H. Stamp
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  7. N. A. Wright
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Editor information

Editors and Affiliations

  1. Hospital de la Princesa, Autonoma University of Madrid, Diego de Leon, 62, 28006, Madrid, Spain

    José M. Pajares M.D., Ph.D. (Professor of Medicine, Head of Department of Gastroenterology) (Professor of Medicine, Head of Department of Gastroenterology)

  2. Free University of Amsterdam, De Boelelaam 1117, 1081 HV, Amsterdam, The Netherlands

    A. Salvador Peña M.D., Ph.D. (Professor of Gastrointestinal Immunology) (Professor of Gastrointestinal Immunology)

  3. Abt. Innere Medizin II, Universitäts Klinik Ulm, Robert-Koch-Str. 8, W-7900, Ulm, Germany

    Peter Malfertheiner Prof. Dr. med.

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© 1993 Springer-Verlag Berlin Heidelberg

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Calam, J. et al. (1993). Bacteria and Gastrin Release. In: Pajares, J.M., Peña, A.S., Malfertheiner, P. (eds) Helicobacter pylori and Gastroduodenal Pathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77486-7_15

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  • DOI: https://doi.org/10.1007/978-3-642-77486-7_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77488-1

  • Online ISBN: 978-3-642-77486-7

  • eBook Packages: Springer Book Archive

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