Reinfection with Helicobacter pylori Due to Intrafamilial Clustering of the Organism

  • R. Collins
  • S. Patchett
  • S. Beattie
  • C. Keane
  • C. O’Morain
Conference paper


Helicobacter pylori is now well established as a pathogen in humans, being the major cause of non-autoimmune chronic gastritis [1]. There is growing evidence that it is also an important factor in duodenal ulcer (DU) relapse, with consequent implications for changes in DU therapy. However, its mode of transmission remains unclear. So far, epidemiological studies suggest possible zoonosis, or else person-to-person spread. We have studied 50 patients with endoscopically proven DU and in whom H. pylori was grown from antral biopsies taken at the time of diagnosis. Following appropriate treatment, at 8-week follow up all were H.pylori negative and their ulcers were healed. One year later, 36% had become reinfected with H. pylori. We set out to investigate if person-to-person spread did occur.


Duodenal Ulcer Pylorus Infection Pylorus Antibody Antral Biopsy Consequent Implication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Marshall BT, Warren JR (1984). Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet i: 1311–15CrossRefGoogle Scholar
  2. 2.
    Mathai E (1989). Campylobacter pylori: laboratory and clinical studies Thesis, University of Dublin, p 81Google Scholar
  3. 3.
    Jones DM, Eldridge J, Fox AJ, Sethi P, Whorwell PJ (1986). Antibodies to the gastric campylobacter-like organism (‘Campylobacter pyloridis’) — clinical correlations and distribution in the normal population. J Med Microbiol 22: 57–62PubMedCrossRefGoogle Scholar
  4. 4.
    Graham DY, Klein PD, Opekun AR, Boutton TW et al. (1988) Epidemiology of Campylobacter pylori infection: ethnic considerations. Scand J Gastroenterol 23 [Suppl 42] :9–13CrossRefGoogle Scholar
  5. 5.
    Berkowicz J, Lee A (1987). Person-to-person transmission of Campylobacter pylori. Lancet ii: 680–681 (letter)CrossRefGoogle Scholar
  6. 6.
    Drumm B, Perez-Perez G, Blaser M, Sherman P (1990) Intrafamilial clustering of Helicobacter pylori infection. N Engl J Med 322:359–363PubMedCrossRefGoogle Scholar
  7. 7.
    Oderda G, Ansaldi N, Boero M, Ponzetto A, Bellis D (1988). Campylobacter pylori in families of children with relapsing gastroduodenal disease due to C. pylori infection. Am J Gastroenterol 83:1437–1438 (letter)PubMedGoogle Scholar
  8. 8.
    Mitchell HM, Bohane TD, Berkowicz J, Hazell SL, Lee A (1987). Antibody to Campylobacter pylori in families of index children with gastrointestinal illness due to C. pylori. Lancet ii :681–682 (letter)CrossRefGoogle Scholar
  9. 9.
    Patchett S, Beattie S, Leen E, Keane C, O’Morain C (1990). The role of H. pylori eradication on the natural history of duodenal ulcer disease. Enfermedades Digestivas, p 264 (abstract)Google Scholar
  10. 10.
    Marshall BJ, Warren JR, Blincow ED, Phillips M et al. (1988). Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet ii: 1437–1441CrossRefGoogle Scholar
  11. 11.
    Coghlan JG, Gilligan D, Humphreys H, McKenna D, Dooley C, Sweeney E, Keane C, O’Morain C (1987). Campylobacter pylori and recurrence of duodenal ulcers-12 months follow up study. Lancet ii: 1109–1111CrossRefGoogle Scholar
  12. 12.
    Lambert JR, Borromeo M, Korman MC, Hansky J, Eaves ER (1987) Effect of colloidal bismuth (De-Nol) on healing and relapse of duodenal ulcers — role of Campylobacter pyloridis. Gastroenterology 92:1489Google Scholar
  13. 13.
    George LL, Borody TJ, Andrews P et al. (1990) Cure of duodenal ulcer after eradication of Helicobacter pylori. Med J Aust 153(3): 145–149PubMedGoogle Scholar
  14. 14.
    Rauws EAJ, Tytgat GNJ (1990). Cure of duodenal ulcer associated with eradication of Helicobacter pylori. Lancet 355 (8700): 1233–1235CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • R. Collins
    • 1
  • S. Patchett
    • 1
  • S. Beattie
    • 1
  • C. Keane
    • 1
  • C. O’Morain
    • 1
  1. 1.Department of GastroenterologyMeath/Adelaide HospitalsDublin 8Ireland

Personalised recommendations