Reinfection with Helicobacter pylori Due to Intrafamilial Clustering of the Organism
Helicobacter pylori is now well established as a pathogen in humans, being the major cause of non-autoimmune chronic gastritis . There is growing evidence that it is also an important factor in duodenal ulcer (DU) relapse, with consequent implications for changes in DU therapy. However, its mode of transmission remains unclear. So far, epidemiological studies suggest possible zoonosis, or else person-to-person spread. We have studied 50 patients with endoscopically proven DU and in whom H. pylori was grown from antral biopsies taken at the time of diagnosis. Following appropriate treatment, at 8-week follow up all were H.pylori negative and their ulcers were healed. One year later, 36% had become reinfected with H. pylori. We set out to investigate if person-to-person spread did occur.
KeywordsDuodenal Ulcer Pylorus Infection Pylorus Antibody Antral Biopsy Consequent Implication
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