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The Mammalian Centromere: Centromere Separation, Kinetochore Proteins and Aneuploidy

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Advances in Mutagenesis Research

Part of the book series: Advances in Mutagenesis Research ((MUTAGENESIS,volume 4))

Abstract

Centromeres (primary constrictions of chromosomes) and kinetochores (specialized protein complex anchored to the centromere) are the sites of activities crucial for chromosome migration. Defects in the centromere, e.g., premature centromere division (Fitzgerald 1989; Vig and Rattner 1989) and kinetochore aberrations, e.g., absence of kinetochores (Vig and Sternes 1991; Vig et al. 1991b) appear to be associated with the genesis of aneuploidy. A host of other factors, e.g., spindle, microtubules, centrosomes, nuclear envelope-associated proteins (see Vig and Sandberg 1987; Resnick and Vig 1989), also affect the outcome of cell division. Recently, the field of chromosome migration has seen a strong upsurge of investigations including molecular biology of the centromere/kinetochore region. The present review, however, deals primarily with the characterization and activity of this region in relation to the genesis of aneuploidy.

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Authors and Affiliations

  1. Department of Biology, University of Neveda, 89557-0015, Reno, NV, USA

    B. K. Vig & B. Richards

  2. Forschungsschwerpunkt 4, Abteilung Wachstum u. Teilung d. Zelle Deutsches Krebsforschungszentrum, D-6900, Heidelberg, Germany

    B. K. Vig & N. Paweletz

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  1. B. K. Vig
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  2. B. Richards
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  3. N. Paweletz
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  1. FB9 der Universität Gesamthochschule Essen, Universitätsstraße 5, Postfach 10 37 64, 4300, Essen 1, Germany

    Günter Obe

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Vig, B.K., Richards, B., Paweletz, N. (1993). The Mammalian Centromere: Centromere Separation, Kinetochore Proteins and Aneuploidy. In: Obe, G. (eds) Advances in Mutagenesis Research. Advances in Mutagenesis Research, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77466-9_9

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  • DOI: https://doi.org/10.1007/978-3-642-77466-9_9

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