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Exploring Genetic and Nongenetic Relationships: The Induction of Micronuclei

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Advances in Mutagenesis Research

Part of the book series: Advances in Mutagenesis Research ((MUTAGENESIS,volume 4))

Abstract

The interphase of genetics and carcinogenesis has been a field of active investigation ever since the realization that mutagenicity, or more precisely the ability to alter DNA, could be the basis of cancer causation. Indeed, this realization, which ultimately led to the “carcinogens are mutagens” paradigm (Ames et al. 1973), also spawned the field of genetic toxicology. Of course, the “somatic mutation theory of cancer causation” as well as the “electrophilic theory of carcinogenesis” (Miller and Miller 1977) received confirmation by the recognition of the role in carcinogenesis of the activation of proto-oncogenes and the deactivation of suppressor genes by mutagenic mechanisms. Indeed, the relevance of these approaches and theories to human cancers was shown by the fact that the majority of carcinogens that cause cancer in humans are mutagenic and or genotoxic (Ennever et al. 1987; Shelby 1988; Bartsch and Malaveille 1989) and that the induction (initiation) of human tumors is accompanied by oncogene activation and/or Suppressor inactivation (Mariyama et al. 1989; Aaronson 1991; Hollstein et al. 1991; Reynolds et al. 1991; Sidransky et al. 1991; Weinberg 1991).

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Author information

Authors and Affiliations

  1. Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, 15261, Pittsburgh, PA, USA

    H. S. Rosenkranz

  2. Department of Chemistry, Case Western Reserve University, 44106, Cleveland, OH, USA

    G. Klopman

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  1. H. S. Rosenkranz
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  2. G. Klopman
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Editors and Affiliations

  1. FB9 der Universität Gesamthochschule Essen, Universitätsstraße 5, Postfach 10 37 64, 4300, Essen 1, Germany

    Günter Obe

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© 1993 Springer-Verlag Berlin Heidelberg

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Rosenkranz, H.S., Klopman, G. (1993). Exploring Genetic and Nongenetic Relationships: The Induction of Micronuclei. In: Obe, G. (eds) Advances in Mutagenesis Research. Advances in Mutagenesis Research, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77466-9_4

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  • DOI: https://doi.org/10.1007/978-3-642-77466-9_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77468-3

  • Online ISBN: 978-3-642-77466-9

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