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Formation of 8-Hydroxyguanine by Oxidative DNA Damage, Its Repair and Its Mutagenic Effects

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Advances in Mutagenesis Research

Part of the book series: Advances in Mutagenesis Research ((MUTAGENESIS,volume 4))

Abstract

In 1982 the analysis of DNA adducts was carried out, particularly guanine adducts, as one approach to the identification of direct-acting mutagens present in broiled foods and environmental materials. On analysis of adduct formation by heated glucose, as a model of broiled foods, glyoxal-Gua and 8-hydroxy-Gua (oh8Gua)1 adducts were detected as major products (Kasai, et al. 1984a; Fig. 1).

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Author notes

  1. S. Nishimura

    Present address: Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, 300-33, Tsukuba, Japan

Authors and Affiliations

  1. Biology Division, National Cancer Center Research Institute, 104, Tokyo, Japan

    H. Kasai & S. Nishimura

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  1. H. Kasai
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  2. S. Nishimura
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  1. FB9 der Universität Gesamthochschule Essen, Universitätsstraße 5, Postfach 10 37 64, 4300, Essen 1, Germany

    Günter Obe

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© 1993 Springer-Verlag Berlin Heidelberg

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Kasai, H., Nishimura, S. (1993). Formation of 8-Hydroxyguanine by Oxidative DNA Damage, Its Repair and Its Mutagenic Effects. In: Obe, G. (eds) Advances in Mutagenesis Research. Advances in Mutagenesis Research, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77466-9_3

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  • DOI: https://doi.org/10.1007/978-3-642-77466-9_3

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