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Opioid Receptor-Coupled Second Messenger Systems

  • Chapter
Opioids

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 104 / 1))

Abstract

Most neurotransmitter and hormone receptors can be grouped into a series of receptor “superfamilies.” Receptors in each of these groups share a number of common properties, including general protein subunit structure, primary sequence homologies, and general gene structure and regulation. Receptors within each of these groups also share common effector systems and, in many cases, the effector systems themselves actually define the individual receptor superfamilies. Most neurotransmitters belong to two major receptor groups: the oligomeric receptor-ion channel complexes, and the G-protein-linked receptors. For neurotransmitters like GABA (acting at GABAA receptors) and acetylcholine (acting at nicotinic sites), receptors are large multisubunit structures which complex together to form ion channels integrated with the receptor-binding sites. For dopamine, norepinephrine, acetylcholine (acting at muscarinic receptors), and many neuropeptides, receptors are coupled to specific G proteins which activate a series of effector systems, several of which are associated with diffusible second messenger systems.

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Authors
  1. S. R. Childers
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Editors and Affiliations

  1. Abteilung Neuropharmakologie, Max-Planck-Institut für Psychiatrie, Am Klopferspitz 18, W-8033, Martinsried, Germany

    Albert Herz

  2. Mental Health Research Institute, School of Medicine, University of Michigan, 205 Zina Picher, 48109, Ann Arbor, MI, USA

    Huda Akil

  3. Medical Center, School of Medicine, New York University, 550 First Avenue, 10016, New York, NY, USA

    Eric J. Simon

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Childers, S.R. (1993). Opioid Receptor-Coupled Second Messenger Systems. In: Herz, A., Akil, H., Simon, E.J. (eds) Opioids. Handbook of Experimental Pharmacology, vol 104 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77460-7_9

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  • DOI: https://doi.org/10.1007/978-3-642-77460-7_9

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