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Opioid Receptor-G Protein Interactions: Acute and Chronic Effects of Opioids

  • Chapter
Opioids

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 104 / 1))

Abstract

It has been accepted for several years that opioid action mediated through μ- and δ-type opioid receptors requires the interaction of the agonist- occupied receptor with a guanine nucleotide binding protein (G protein). Accumulating evidence suggests that a similar mechanism is an essential component of κ-type opioid receptor function. In this chapter, we will discuss the evidence supporting these conclusions and review similarities and differences between opioid receptor-G protein interactions and the functions of other G protein-linked receptor systems. The evidence that tolerance to opioid agonist actions and the development of dependence on opioid agonist after chronic exposure might also be related to modified interactions between receptor and G protein, and also to changes in the concentrations of individual forms of G proteins, will also be considered.

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Authors
  1. B. M. Cox
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Editors and Affiliations

  1. Abteilung Neuropharmakologie, Max-Planck-Institut für Psychiatrie, Am Klopferspitz 18, W-8033, Martinsried, Germany

    Albert Herz

  2. Mental Health Research Institute, School of Medicine, University of Michigan, 205 Zina Picher, 48109, Ann Arbor, MI, USA

    Huda Akil

  3. Medical Center, School of Medicine, New York University, 550 First Avenue, 10016, New York, NY, USA

    Eric J. Simon

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© 1993 Springer-Verlag Berlin Heidelberg

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Cox, B.M. (1993). Opioid Receptor-G Protein Interactions: Acute and Chronic Effects of Opioids. In: Herz, A., Akil, H., Simon, E.J. (eds) Opioids. Handbook of Experimental Pharmacology, vol 104 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77460-7_8

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  • DOI: https://doi.org/10.1007/978-3-642-77460-7_8

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