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Opioids and Sensory Processing in the Central Nervous System

  • Chapter
Opioids

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 104 / 1))

Abstract

When considering opioids and sensory systems there are two important questions. The first deals with how opiate drugs relieve pain; the second consideration is how opioid peptides physiologically influence sensory processing. Since pain is a perception, the potential sites at which a drug could act to produce an alteration in its quality or intensity are legion. Much of the research discussed in this section demonstrates that opiates do reduce the amount of information reaching the brain in response to a peripheral stimulus normally perceived as painful. Thus, these experiments lead to the conclusion that opiates produce a diminution in the intensity of perceived pain through a reduction in the transmitted message. If opiates also act in the brain to alter perception to a given message, then this currently seems unamenable to investigation by electrophysiological means. But the possibility remains.

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  1. A. W. Duggan
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  2. S. M. Fleetwood-Walker
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Editors and Affiliations

  1. Abteilung Neuropharmakologie, Max-Planck-Institut für Psychiatrie, Am Klopferspitz 18, W-8033, Martinsried, Germany

    Albert Herz

  2. Mental Health Research Institute, School of Medicine, University of Michigan, 205 Zina Picher, 48109, Ann Arbor, MI, USA

    Huda Akil

  3. Medical Center, School of Medicine, New York University, 550 First Avenue, 10016, New York, NY, USA

    Eric J. Simon

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Duggan, A.W., Fleetwood-Walker, S.M. (1993). Opioids and Sensory Processing in the Central Nervous System. In: Herz, A., Akil, H., Simon, E.J. (eds) Opioids. Handbook of Experimental Pharmacology, vol 104 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77460-7_29

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