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Biosynthesis of Enkephalins and Proenkephalin-Derived Peptides

  • Chapter
Opioids

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 104 / 1))

Abstract

The enkephalins [Met5]- and [Leu5]enkephalin were isolated in 1975 by Hughes et al. Since then, numerous other opioid peptides have been characterized although none of these are found in levels comparable to [Met5]enkephalin in brain tissue (see Table 1). Brain levels of prodynorphin and proopiomelanocortin-derived peptides, for example, are at least one order of magnitude lower than those of [Met5]enkephalin. When compared to other nonopioid peptides, the levels of [Met5]enkephalin are of the same order as two other widely distributed peptides, CCK8 and somatostatin (see review in Crawley 1985).

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Authors
  1. J. Rossier
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Editors and Affiliations

  1. Abteilung Neuropharmakologie, Max-Planck-Institut für Psychiatrie, Am Klopferspitz 18, W-8033, Martinsried, Germany

    Albert Herz

  2. Mental Health Research Institute, School of Medicine, University of Michigan, 205 Zina Picher, 48109, Ann Arbor, MI, USA

    Huda Akil

  3. Medical Center, School of Medicine, New York University, 550 First Avenue, 10016, New York, NY, USA

    Eric J. Simon

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© 1993 Springer-Verlag Berlin Heidelberg

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Rossier, J. (1993). Biosynthesis of Enkephalins and Proenkephalin-Derived Peptides. In: Herz, A., Akil, H., Simon, E.J. (eds) Opioids. Handbook of Experimental Pharmacology, vol 104 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77460-7_18

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  • DOI: https://doi.org/10.1007/978-3-642-77460-7_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77462-1

  • Online ISBN: 978-3-642-77460-7

  • eBook Packages: Springer Book Archive

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