Opioids pp 393-421 | Cite as

Proopiomelanocortin Biosynthesis, Processing, and Secretion: Functional Implications

  • E. Young
  • D. Bronstein
  • H. Akil
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 104 / 1)

Abstract

Peptide hormones and transmitters are synthesized as large molecular weight precursors, prohormones (Herbert and Uhler 1982; Steiner and Oyer 1967), which are processed intracellularly in neurotransmitter- or hormone-secreting cells to yield smaller active fragments. Within the structure of the hormone are processing “signals” that direct cellular enzymes to cut out or “cleav” the peptide hormones. Although the amino acid sequence of the prohormone determines the placement of processing signals, the particular signals recognized and consequently cleaved vary between types of cells. This cell-specific processing gives rise to different end products from the identical prohormone in different cells. It also results in biologically active sequences buried within the sequence of other end products in some tissues. In addition, different tissues can chemically modify the peptides posttranslationally, often producing substantial changes in the biological activity of the peptide products. All of the above variations can be combined to produce very different mixtures of biologically active products from different cell types. Finally, chronic activation of any cell may alter the mixture of secreted peptides, endowing these neurosecretory cells with a flexibility to meet the demands for one peptide hormone without shifting the homeostatic balance for its co-secreted peptide partner.

Keywords

Dopamine Amide Adenoma Lysine Interferon 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • E. Young
  • D. Bronstein
  • H. Akil

There are no affiliations available

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